International Chemical Safety Cards THEOPHYLLINE ICSC: 0678 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione 1,3-Dimethylxanthine C7H8N4O2 Molecular mass: 180.2 ICSC #    0678 CAS #     58-55-9 RTECS # XH3850000 UN #        1544 April 18, 2007 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: use appropriate extinguishing media. EXPLOSION EXPOSURE  •INHALATION see Ingestion. Avoid inhalation of fine dust and mist. Fresh air, rest.  •SKIN Protective gloves. Remove contaminated clothes. Rinse skin with plenty of water or shower.  •EYES Safety spectacles. First rinse with plenty of water (remove contact lenses if easily possible).  •INGESTION Headache. Nausea. Vomiting. Irritability. Insomnia. Palpitation. Convulsions. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Personal protection: particulate filter adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Then remove to safe place. Separated from food and feedstuffs . Do not transport with food and feedstuffs. UN Hazard Class: 6.1 UN Packing Group: III Signal: Danger Skull-Health haz Toxic if swallowed May be harmful if inhaled dust May cause harm to breast-fed children Causes damage to vascular system and kidneys Causes damage to kidneys through prolonged or repeated exposure SEE IMPORTANT INFORMATION ON BACK ICSC: 0678 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards THEOPHYLLINE ICSC: 0678 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: WHITE CRYSTALLINE POWDER. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic fumes including nitrogen oxides . OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body in hazardous amounts by ingestion. INHALATION RISK: A nuisance-causing concentration of airborne particles can be reached quickly when dispersed. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the heart and central nervous system , resulting in cardiac dysrhythmia and convulsions . The effects may be delayed. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Melting point: 270-274°C Density: 500 kg/m³ Solubility in water, g/100 ml: 0.55-0.8 Vapour pressure, Pa at °C: negligible Octanol/water partition coefficient as log Pow: -0.02 (estimated) ENVIRONMENTAL DATA N O T E S Transport Emergency Card: TEC (R)-61GT2-III ADDITIONAL INFORMATION ICSC: 0678 THEOPHYLLINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.