International Chemical Safety Cards

ISOPHORONE DIISOCYANATE ICSC: 0499
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
3-Isocyanatomethyl - 3,5,5-trimethylcyclohexyl isocyanate
Isocyanic acid, methylene (3,5,5-trimethyl-3, 1-cyclohexylene)ester
IPDI
C12H18N2O2 / (CH3)2C6H7(CH3)(N=C=O)CH2N=C=O
Molecular mass: 222.3
6 Harmful - Stow Away from Foodstuffs placard 6 Poison placard ICSC #    0499
CAS #     4098-71-9
RTECS # NQ9370000
UN #        2290
EC #         615-008-00-5
November 11, 2008 Validated
Fa, rack: 10-2004, Sankt Augustin; TEC (R), MAK updated; MAK corrected 2005
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting. /toxic nitrogen oxides and hydrogen cyanide
NO open flames.
Water spray, foam, powder, carbon dioxide
EXPLOSION


EXPOSURE
AVOID ALL CONTACT!

 •INHALATION Cough. Sore throat. Burning sensation. spnea, breathing difficulty); p. tract irritation;
Closed system.
Fresh air, rest. Half-upright position. Refer immediately for medical attention.
 •SKIN Redness. Pain. Serious skin burns. h), very strong skin sensitizer (ref. 24, 28), R38, min. irritaiting conc. in mice-1%, strong irritation (ref.40); rosis, OECD-corrosive)
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. omments;
 •EYES Redness. Pain. ref. 28), strong irritation (ref.40);;
Face shield or eye protection in combination with breathing protection.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
 •INGESTION Sore throat. Burning sensation. Abdominal pain. o sequence
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Treat remaining liquid with dilute ammonia solution. Do NOT let this chemical enter the environment. nger area. ! uild-up may rupture closed containers,30 (into open containers); 8% ammonia) o 13902 (harmful to aquatic organisms);
Separated from bases, acids, alcohols, amines, amides, phenols, mercaptans, Keep in a well-ventilated room. Well closed. Cool. Dry. Store in an area without drain or sewer access. ; nh, may cause resp.irrit.; ith moisture, do not reseal); s; oisture forms CO2- may rupture closed containers); aquatic organisms, link to 21245
Airtight. Do not transport with food and feedstuffs.
Note: 2
T symbol
N symbol
R: 23-36/37/38-42/43-51/53
S: 1/2-26-28-38-45-61
UN Hazard Class: 6.1
UN Packing Group: III
Signal: Danger
Corr-Skull-Health haz
Fatal if inhaled mist
Harmful in contact with skin
Causes severe skin burns and eye damage
Causes serious eye irritation
May cause allergic or asthmatic symptoms or breathing difficulties if inhaled
May cause allergic skin reaction
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0499 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

ISOPHORONE DIISOCYANATE ICSC: 0499
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PHYSICAL STATE; APPEARANCE:
COLOURLESS TO YELLOW LIQUID , WITH PUNGENT ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance may polymerize due to warming and under the influence of strong bases and metal compounds. The substance decomposes on burning producing toxic and corrosive fumes , including hydrogen cyanide and nitrogen oxides. Reacts violently with acids, alcohols, amines, bases, amides, phenols, and mercaptanes causing toxic, fire and explosion hazard. Attacks plastic, rubber. f fire); 28) and isophorone diamine - toxic and corrosive comp.(ref.26), with water or moist air will release toxic, corrosive or flammable gases (ref.30); eneration of heat), 30, 43; rd karten 23rd ed

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.005 ppm as TWA (ACGIH 2008).
MAK: 0.005 ppm.
Peak limitation category: I(1);
sensitization of respiratory tract and skin (Sah);
Pregnancy risk group: D;
(DFG 2008).
value of 0.01 ml/m3 (0.092 mg/m3) should not be exceeded;
alues (NOT on card):
OSHA PEL: none
NIOSH REL: TWA 0.005 ppm (0.045 mg/m3) ST 0.02 ppm (0.180 mg/m3) skin
NIOSH IDLH: N.D. See: IDLH INDEX


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol and through the skin. l toxicity (ref.28); LD50 oral-rat: greater than 1000 mg/kg (ref.30); LD50 oral-rat: 1270 mg/kg b.w (ref. 27); 50 : 1060 mg/kg (ref. 25);

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the skin and is severely irritating to the eyes. The aerosol is irritating to the respiratory tract. ur when heating (ref. 28); iance (ref.27); 38, scores for erythema: 3.61 (rabbit); rat, 30 min: 0.011 mg/l (ref.27); rats),41,47 (high aerosol conc. may cause pulm. oedema - potent. effect), 44,non cardiogenic pulm. edema (ref.30),43; human-severe asthma soon after indroduction of a new paint contain. IPDI),29,37,43; er one contact)

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma. See Notes. very large exposure, or by multiple exposures (ref.28), human data,8,24,28,33,40, 45,R42;
PHYSICAL
PROPERTIES
Boiling point at 1,33 kPa: 158°C
Decomposes at 310°C

Melting point: -60°C
Relative density (water = 1): 1.06
Solubility in water: 15 mg/l
reaction
Vapour pressure, Pa at 20°C: 0.04
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point:
155°C c.c.
Auto-ignition temperature: 430°C
Explosive limits, vol% in air: 0.7-4.5
Octanol/water partition coefficient as log Pow: 4.75 (calc.)
ENVIRONMENTAL
DATA
Environmental Hazard placard This substance may be hazardous in the environment; special attention should be given to aquatic organisms.
N O T E S
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home. l hours, 48 h, immediately, at night); threshold (0.25 mg/m3) is above TLV);
Transport Emergency Card: TEC (R)-61S2290
or 61GT1-III
NFPA Code: H2; F1; R1; W
ADDITIONAL INFORMATION


ICSC: 0499 ISOPHORONE DIISOCYANATE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.