International Chemical Safety Cards

COUMAPHOS ICSC: 0422
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
O-3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate
Phosphorothioic acid O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester
O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate
C14H16ClO5PS
Molecular mass: 362.78
6 Poison placard Marine Pollutant placard ICSC #    0422
CAS #     56-72-4
RTECS # GN6300000
UN #        3027
EC #         015-038-00-3
July 10, 1997 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Not combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.

In case of fire in the surroundings: powder, water spray, foam, carbon dioxide.
EXPLOSION


EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!
IN ALL CASES CONSULT A DOCTOR!
 •INHALATION Convulsions. Dizziness. Sweating. Laboured breathing. Nausea. Unconsciousness. Pupillary constriction, muscle cramp, excessive salivation. Symptoms may be delayed (see Notes).
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
 •SKIN MAY BE ABSORBED! (Further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
 •EYES
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION Abdominal cramps. Diarrhoea. Vomiting. (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Evacuate danger area! Do NOT wash away into sewer. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place.
Separated from food and feedstuffs . Well closed. Keep in a well-ventilated room.
Do not transport with food and feedstuffs.
Severe
marine pollutant.
T+ symbol
N symbol
R: 21-28-50/53
S: 1/2-28-36/37-45-60-61
UN Hazard Class: 6.1
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0422 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

COUMAPHOS ICSC: 0422
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PHYSICAL STATE; APPEARANCE:
COLOURLESS CRYSTALS , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes including sulfur oxides , phosphorus oxides and hydrogen chloride . Reacts slowly with bases to be hydrolyzed.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.05 mg/m
(inhalable fraction & vapour)
as TWA (skin) A4 (not classifiable as a human carcinogen); BEI issued (ACGIH 2007).
MAK not established.


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
Cholinesterase inhibitor. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.
PHYSICAL
PROPERTIES
Melting point: 91C
Density: 1.47
g/cm
Solubility in water:
none
Vapour pressure, Pa at 20C: 0.000013
Octanol/water partition coefficient as log Pow: 4.13
ENVIRONMENTAL
DATA
Environmental Hazard placard The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment; special attention should be given to fish, crustacea, birds and mammals. Bioaccumulation of this chemical may occur in fish. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.
N O T E S
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Carrier solvents used in commercial formulations may change physical and toxicological properties. Asuntol, Co-ral, Meldane, Muscatox, Perizin, Resitox, Negashunt are trade names. Card has been partly updated in October 2005. See section Emergency Response.
Transport Emergency Card: TEC (R)-61GT7-I
Card has been partially updated in July 2007: see Occupational Exposure Limits.
ADDITIONAL INFORMATION


ICSC: 0422 COUMAPHOS
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.