International Chemical Safety Cards

1,4-BENZENEDIAMINE DIHYDROCHLORIDE ICSC: 0386
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
1,4-Phenylenediamine dihydrochloride
1,4-Diaminobenzene dihydrochloride
4-Aminoaniline dihydrochloride
p-Phenylenediamine dihydrochloride
C6H8N2• 2HCl / C6H4(NH2)2 • 2HCl
Molecular mass: 181.1
6 Harmful - Stow Away from Foodstuffs placard 6 Poison placard ICSC #    0386
CAS #     624-18-0
RTECS # ST0350000
UN #        1673
EC #         612-029-00-1
October 19, 1999 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray, foam, powder, carbon dioxide.
EXPLOSION Finely dispersed particles form explosive mixtures in air.
Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting.

EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE!

 •INHALATION Dizziness. Headache. Laboured breathing. Blue lips or finger nails. Blue skin. Confusion. Convulsions. Nausea. Unconsciousness.
Local exhaust or breathing protection.
Fresh air, rest. Refer for medical attention.
 •SKIN
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
 •EYES Redness.
Safety goggles or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION (See Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Refer for medical attention. Induce vomiting (ONLY IN CONSCIOUS PERSONS!).
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Sweep spilled substance into containers. Carefully collect remainder, then remove to safe place. Personal protection: chemical protection suit including self-contained breathing apparatus.
Separated from food and feedstuffs .
Do not transport with food and feedstuffs.
T symbol
N symbol
R: 23/24/25-36-43-50/53
S: 1/2-28-36/37-45-60-61
UN Hazard Class: 6.1
UN Packing Group: III
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0386 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

1,4-BENZENEDIAMINE DIHYDROCHLORIDE ICSC: 0386
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D

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A
PHYSICAL STATE; APPEARANCE:
WHITE TO SLIGHTLY REDDISH CRYSTALS.

PHYSICAL DANGERS:
Dust explosion possible if in powder or granular form, mixed with air.

CHEMICAL DANGERS:
The substance decomposes on heating producing toxic and corrosive fumes ( nitrogen oxides , hydrogen chloride ).

OCCUPATIONAL EXPOSURE LIMITS:
TLV: (as 1,4-Benzenediamine) 0.1 mg/m³ as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2005).
MAK: (as p-phenylene diamine) 0.1 mg/m³ (Inhalable fraction).
Peak limitation category: II(2);
skin absorption (H); sensitization of skin (Sh);
Carcinogen category: 3B. Pregnancy risk group: D
(DFG 2005).


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes. The substance may cause effects on the blood and kidneys , resulting in formation of methaemoglobin and kidney impairment. Medical observation is indicated. The effects may be delayed.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma.
PHYSICAL
PROPERTIES
Melting point: 275°C
Solubility in water:
very good
Relative vapour density (air = 1): 6.2
ENVIRONMENTAL
DATA

N O T E S
Depending on the degree of exposure, periodic medical examination is indicated. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should never again come into contact with this substance. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Also consult ICSC # 0805: Phenylenediamine. Card has been partly updated in October 2005 and August 2006: see sections Emergency Response, Occupational Exposure Limits.
Transport Emergency Card: TEC (R)-61GT2-III
ADDITIONAL INFORMATION


ICSC: 0386 1,4-BENZENEDIAMINE DIHYDROCHLORIDE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.