International Chemical Safety Cards

p-TOLUIDINE ICSC: 0343
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
4-Aminotoluene
p-Methylaniline
1-Amino-4-methylbenzene
C7H9N / C6H4CH3NH2
Molecular mass: 107.2
6 Poison placard ICSC #    0343
CAS #     106-49-0
RTECS # XU3150000
UN #        3451
EC #         612-160-00-4
November 27, 2009 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray, foam, powder, carbon dioxide
EXPLOSION Above 87C explosive vapour/air mixtures may be formed.
Above 87C use a closed system, ventilation.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
 •INHALATION Blue lips or finger nails. Blue skin. Confusion. Dizziness. Headache. Shortness of breath. Weakness. Convulsions. Nausea. Unconsciousness.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.
 •SKIN MAY BE ABSORBED! Redness. Blue lips or fingernails. Blue skin. (Further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.
 •EYES Redness. Pain.
Safety goggles.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
 •INGESTION Blue lips or fingernails. Blue skin. Dizziness. Headache. Laboured breathing (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Refer immediately for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment.
Provision to contain effluent from fire extinguishing. Separated from strong oxidants, strong acids, food and feedstuffs . Well closed. Ventilation along the floor. Keep in the dark. Store in an area without drain or sewer access.
Do not transport with food and feedstuffs.
T symbol
N symbol
R: 23/24/25-36-40-43-50
S: 1/2-28-36/37-45-61
UN Hazard Class: 6.1
UN Packing Group: II
Signal: Danger
Skull-Health haz-Enviro
Combustible liquid
Toxic if swallowed
Toxic in contact with skin
Toxic if inhaled
Causes eye irritation
May cause allergic skin reaction
Causes damage to blood
Very toxic to aquatic life
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0343 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

p-TOLUIDINE ICSC: 0343
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PHYSICAL STATE; APPEARANCE:
COLOURLESS FLAKES , TURNS DARK ON EXPOSURE TO AIR AND LIGHT.

PHYSICAL DANGERS:
As a result of flow, agitation, etc., electrostatic charges can be generated.

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including nitrogen oxides . Reacts with strong oxidants and strong acids . Attacks some forms of plastic .

OCCUPATIONAL EXPOSURE LIMITS:
OSHA PEL: none
NIOSH REL: Ca See Appendix A
NIOSH IDLH: Ca N.D. See: IDLH INDEX
TLV: 2 ppm (skin); as TWA A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued (ACGIH 2009).
MAK: skin absorption (H); sensitization of skin (Sh);
Carcinogen category: 3B
(DFG 2009).


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes. The substance may cause effects on the blood , resulting in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Tumours have been detected in experimental animals but may not be relevant to humans. MAK
PHYSICAL
PROPERTIES
Boiling point: 200C
Melting point: 44-45C
Relative density (water = 1): 1.05
Solubility in water, g/100 ml at 20C: 0.75
(poor)
Vapour pressure, kPa at 42C: 0.13
Relative vapour density (air = 1): 3.7
Relative density of the vapour/air-mixture at 20C (air = 1): 1.00
Flashpoint: 87C c.c.
Auto-ignition temperature: 480C
Explosive limits, vol% in air: 1.1-6.6
Octanol/water partition coefficient as log Pow: 1.39
ENVIRONMENTAL
DATA
Environmental Hazard placard The substance is very toxic to aquatic organisms. It is strongly advised that this substance does not enter the environment. magna 48h-EC50=0.12 mg/l; Dano rerio 96h-LC50=11.5 mg/l; Poecillia reticulata 14dLC50=10.7 mg/l; Scenedesmus oliquus 48h-Ec50=62.9 mg/l; Scenedesmus quadricauda 96hEbC3=8.0 mg/l
N O T E S
Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home. See also ICSC 0341 o-Toluidine and 0342 m-Toluidine.
NFPA Code: H3; F2; R0
ADDITIONAL INFORMATION


ICSC: 0343 p-TOLUIDINE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.