International Chemical Safety Cards

4-NITROANILINE ICSC: 0308
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
p-Nitroaniline
1-Amino-4-nitrobenzene
C.I. 37035
C6H6N2O2
Molecular mass: 138.1
6 Poison placard ICSC #    0308
CAS #     100-01-6
RTECS # BY7000000
UN #        1661
EC #         612-012-00-9
December 03, 2001 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Many reactions may cause fire or explosion.
NO open flames. NO contact with combustible substances.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Finely dispersed particles form explosive mixtures in air.
Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting.
In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.
EXPOSURE
PREVENT DISPERSION OF DUST!

 •INHALATION Blue lips or finger nails. Blue skin. Headache. Dizziness. Nausea. Confusion. Convulsions. Laboured breathing. Unconsciousness.
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration if indicated. Refer for medical attention.
 •SKIN MAY BE ABSORBED! (Further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
 •EYES Redness. Pain.
Face shield, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION (Further see Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. (Extra personal protection: P3 filter respirator for toxic particles.) Do NOT let this chemical enter the environment.
Separated from strong acids, strong oxidants, combustible and reducing substances, food and feedstuffs . Dry.
Do not transport with food and feedstuffs.
Note: C
T symbol
R: 23/24/25-33-52/53
S: 1/2-28-36/37-45-61
UN Hazard Class: 6.1
UN Packing Group: II
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0308 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

4-NITROANILINE ICSC: 0308
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PHYSICAL STATE; APPEARANCE:
YELLOW CRYSTALS OR POWDER.

PHYSICAL DANGERS:
Dust explosion possible if in powder or granular form, mixed with air.

CHEMICAL DANGERS:
May explode on heating. On combustion, forms toxic fumes of nitrogen oxides. Reacts with strong acids , strong oxidants and strong reducing agents . Reacts with organic materials in presence of moisture causing fire hazard.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 3 mg/m
(as TWA)
(skin) A4 (not classifiable as a human carcinogen); BEI issued (ACGIH 2005).
MAK: skin absorption (H);
Carcinogen category: 3A
(DFG 2005).
OSHA PEL: TWA 6 mg/m3 (1 ppm) skin
NIOSH REL: TWA 3 mg/m3 skin
NIOSH IDLH: 300 mg/m3 See: 100016


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20C; on spraying or dispersing, however, much faster.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is mildly irritating to the eyes . The substance may cause effects on the blood , resulting in formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the blood , resulting in the formation of methaemoglobin. See Notes.
PHYSICAL
PROPERTIES
Boiling point: 332C
Melting point: 148C
Density: 1.4
g/cm
Solubility in water, g/100 ml at 18.5C: 0.08
Vapour pressure, Pa at 20C: 0.2
Relative vapour density (air = 1): 4.8
Flash point: 199C
Octanol/water partition coefficient as log Pow: 2.66
ENVIRONMENTAL
DATA
Environmental Hazard placard The substance is harmful to aquatic organisms. Do not let this chemical enter the environment.
N O T E S
Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Also consult ICSC 0306 2-Nitroaniline, and ICSC 0307 3-Nitroaniline.
Transport Emergency Card: TEC (R)-61G12b

NFPA Code: H 3; F 1; R 2;
ADDITIONAL INFORMATION


ICSC: 0308 4-NITROANILINE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.