International Chemical Safety Cards

HEXAMETHYLENE DIISOCYANATE ICSC: 0278
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
HMDI
1,6-Hexamethylene diisocyanate
1,6-Diisocyanatohexane
C8H12N2O2 / OCN(CH2)6NCO
Molecular mass: 168.2
6 Poison placard ICSC #    0278
CAS #     822-06-0
RTECS # MO1740000
UN #        2281
EC #         615-011-00-1
September 20, 1993 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, carbon dioxide.
EXPLOSION


EXPOSURE
PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
 •INHALATION Burning sensation. Cough. Laboured breathing. Shortness of breath. Sore throat.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
 •SKIN MAY BE ABSORBED! Redness. Skin burns. Blisters.
Protective gloves.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
 •EYES Redness. Pain. Swelling of eyelids.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION
Do not eat, drink, or smoke during work.
Rinse mouth. Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: complete protective clothing including self-contained breathing apparatus.
Separated from incompatible materials , see Chemical Dangers, food and feedstuffs . Cool. Dry. Keep in the dark. Ventilation along the floor.
Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.
T symbol
R: 23-36/37/38-42/43
S: 1/2-26-28-38-45
UN Hazard Class: 6.1
UN Packing Group: II
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0278 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

HEXAMETHYLENE DIISOCYANATE ICSC: 0278
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PHYSICAL STATE; APPEARANCE:
CLEAR, COLOURLESS LIQUID , WITH PUNGENT ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance will polymerize under the influence of temperatures above 93C. On combustion, forms toxic and corrosive fumes including nitrogen oxides and hydrogen cyanide (see ICSC 0492). The substance decomposes on contact with water to form amine and polyureas. Reacts violently with acids , alcohols , amines , bases and oxidants . causing fire and explosion hazard. Attacks copper.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.005 ppm as TWA; (ACGIH 2004).
MAK: 0.005 ppm, 0.035 mg/m;
Peak limitation category: I(1);
sensitization of respiratory tract and skin (Sah);
Pregnancy risk group: D;
(DFG 2006).
OSHA PEL: none
NIOSH REL: TWA 0.005 ppm (0.035 mg/m3) C 0.020 ppm (0.140 mg/m3) 10-minute
NIOSH IDLH: N.D. See: IDLH INDEX


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol and through the skin.

INHALATION RISK:
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20C; on spraying or dispersing, however, much faster.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes, the skin and and the respiratory tract. Exposure far above the OEL may result in respiratory sensitization.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma (see Notes).
PHYSICAL
PROPERTIES
Boiling point: 255C
Melting point: -67C
Relative density (water = 1): 1.05
Solubility in water:
reaction
Vapour pressure, Pa at 25C: 7
Relative vapour density (air = 1): 5.8
Relative density of the vapour/air-mixture at 20C (air = 1): 1.00
Flash point: 140C o.c.
Auto-ignition temperature: 454C
Explosive limits, vol% in air: 0.9-9.5
Octanol/water partition coefficient as log Pow: 1.08
ENVIRONMENTAL
DATA

N O T E S
Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. Workers exposed to this compound may be sensitized to other isocyanates (asthma). The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home. Desmodur H and Desmodur N are trade names.
Transport Emergency Card: TEC (R)-61GT1-II
Card has been partially updated in July 2007: see Occupational Exposure Limits.
ADDITIONAL INFORMATION


ICSC: 0278 HEXAMETHYLENE DIISOCYANATE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.