International Chemical Safety Cards

N,N-DIMETHYLACETAMIDE

ICSC: 0259

Acetic acid dimethylamide
Dimethylacetamide
CH₃CON(CH₃)₂
Molecular mass: 87.1
ICSC #    0259
CAS #     127-19-5
RTECS # AB7700000
EC #         616-011-00-4
September 20, 1993 Validated

TYPES OF HAZARD/ EXPOSURE	ACUTE HAZARDS/ SYMPTOMS	PREVENTION	FIRST AID/ FIRE FIGHTING
FIRE	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION	Above 70°C explosive vapour/air mixtures may be formed.	Above 70°C closed system, ventilation, and explosion-proof electrical equipment.

EXPOSURE		STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!
•INHALATION	Headache. Nausea. Vomiting.	Ventilation, local exhaust, or breathing protection.	Fresh air, rest. Artificial respiration if indicated. Refer for medical attention.
•SKIN	MAY BE ABSORBED! Redness. (Further see Inhalation).	Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES	VAPOUR WILL BE ABSORBED! Redness. Pain.	Face shield.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION	Abdominal cramps. Diarrhoea. (Further see Inhalation).	Do not eat, drink, or smoke during work.	Rinse mouth. Give plenty of water to drink. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.

Well closed. Ventilation along the floor.

T symbol
R: 61-20/21
S: 53-45

SEE IMPORTANT INFORMATION ON BACK

ICSC: 0259

Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

N,N-DIMETHYLACETAMIDE

ICSC: 0259

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PHYSICAL STATE; APPEARANCE:
OILY COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:

CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes nitrogen oxides Attacks many plastics.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 10 ppm as TWA (skin) A4 (not classifiable as a human carcinogen); BEI issued (ACGIH 2005).
MAK: 10 ppm 36 mg/mł
Peak limitation category: II(2);
skin absorption (H);
Pregnancy risk group: C;
(DFG 2004).
OSHA PEL: TWA 10 ppm (35 mg/m³) skin
NIOSH REL: TWA 10 ppm (35 mg/m³) skin
NIOSH IDLH: 300 ppm See: 127195

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin.

INHALATION RISK:
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes and the skin

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The liquid defats the skin. The substance may have effects on the central nervous system and liver.

PHYSICAL
PROPERTIES

Boiling point: 165°C
Melting point: -20°C
Relative density (water = 1): 0.94
Solubility in water:
miscible
Vapour pressure, kPa at 20°C: 0.33

Relative vapour density (air = 1): 3.01
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 70°C (o.c.)
Auto-ignition temperature: 490°C
Explosive limits, vol% in air: 1.8 (at 100°C) - 11.5 (at 160°C)
Octanol/water partition coefficient as log Pow: -0.77

ENVIRONMENTAL
DATA

This substance may be hazardous to the environment; special attention should be given to soil contaminationl.

N O T E S

Use of alcoholic beverages enhances the harmful effect. Depending on the degree of exposure, periodic medical examination is suggested. No odour warning if toxic concentrations are present. Absorption through the skin proceeds very quickly. Most types of protective gloves are not entirely effective. Card has been partly updated in October 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.

NFPA Code: H 2; F 2; R 0;

ADDITIONAL INFORMATION

ICSC: 0259	N,N-DIMETHYLACETAMIDE
(C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE:

Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.