International Chemical Safety Cards

BENZIDINE ICSC: 0224
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
(1,1'-Biphenyl)-4,4'-diamine
4,4'-Diaminobiphenyl
p-Diaminodiphenyl
Biphenyl-4,4'-ylenediamine
C12H12N2 / NH2C6H4C6H4NH2
Molecular mass: 184.2
6 Poison placard ICSC #    0224
CAS #     92-87-5
RTECS # DC9625000
UN #        1885
EC #         612-042-00-2
November 24, 2009 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Water spray, foam, powder, carbon dioxide .
EXPLOSION


EXPOSURE See EFFECTS OF LONG-TERM OR REPEATED EXPOSURE.
AVOID ALL CONTACT!

 •INHALATION
Closed system and ventilation.
Fresh air, rest.
 •SKIN MAY BE ABSORBED!
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Wear protective gloves when administering first aid.
 •EYES
Face shield or eye protection in combination with breathing protection if powder.
Rinse with plenty of water (remove contact lenses if easily possible).
 •INGESTION
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus. at update 2008.;
Provision to contain effluent from fire extinguishing. Separated from strong oxidants, food and feedstuffs . Keep in the dark. Well closed. Store in an area without drain or sewer access. 00
Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.
Note: E
T symbol
N symbol
R: 45-22-50/53
S: 53-45-60-61
UN Hazard Class: 6.1
UN Packing Group: II
Signal: Danger
Excl mark-Health haz-Enviro
Harmful if swallowed
Suspected of causing genetic defects
May cause cancer
Very toxic to aquatic life with long lasting effects
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0224 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

BENZIDINE ICSC: 0224
I

M

P

O

R

T

A

N

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D

A

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A
PHYSICAL STATE; APPEARANCE:
COLOURLESS OR REDDISH CRYSTALLINE POWDER , TURNS DARK ON EXPOSURE TO AIR AND LIGHT. ; from WHITE at update 2008.;

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating and on burning producing toxic fumes including nitrogen oxides . Reacts violently with strong oxidants , especially nitric acid . mbustible); ,43;

OCCUPATIONAL EXPOSURE LIMITS:
TLV: (skin), A1 (confirmed human carcinogen); (ACGIH 2009).
MAK: skin absorption (H);
Carcinogen category: 1;
(DFG 2009).
OSHA PEL: 1910.1010 See Appendix B See Appendix C
NIOSH REL: Ca See Appendix A See Appendix C
NIOSH IDLH: Ca N.D. See: IDLH INDEX


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. of inhalation absorption in workers exposed to benzidine), 24(readily absorbed through intact mammalin skin, by the dermal absorption study with C14-benzidine); y agreed that benzidine can be absorbed through the skin, Log Pow (1.36) is considered to allow significant dermal absorption.), 24(can be absorbed in the intestins, by oral absorption study with 3H-benzidine);

INHALATION RISK:
Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:


EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
This substance is carcinogenic to humans.
PHYSICAL
PROPERTIES
Boiling point: 401C
Melting point: 120C
Density: 1.3
g/cm
Solubility in water, g/100 ml at 25C: <0.05 (very poor)
Relative vapour density (air = 1): 6.4
Octanol/water partition coefficient as log Pow: 1.34
ENVIRONMENTAL
DATA
Environmental Hazard placard The substance is very toxic to aquatic organisms. It is strongly advised that this substance does not enter the environment.
N O T E S
Do NOT take working clothes home.
ADDITIONAL INFORMATION


ICSC: 0224 BENZIDINE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.