International Chemical Safety Cards

ACETIC ANHYDRIDE ICSC: 0209
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
Acetic acid, anhydride
Acetic oxide
Ethanoic anhydride
Acetyl oxide
C4H6O3/(CH3CO)2O
Molecular mass: 102.1
3 Flammable Liquid placard 8 Corrosive placard ICSC #    0209
CAS #     108-24-7
RTECS # AK1925000
UN #        1715
EC #         607-008-00-9
April 04, 2006 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Flammable.
NO open flames, NO sparks, and NO smoking.
Alcohol-resistant foam, powder, carbon dioxide (see Notes).
EXPLOSION Above 49C explosive vapour/air mixtures may be formed.
Above 49C use a closed system, ventilation, and explosion-proof electrical equipment.
In case of fire: cool drums, etc., by spraying with water but avoid contact of the substance with water.
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
 •INHALATION Cough. Laboured breathing. Shortness of breath. Sore throat.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
 •SKIN Redness. skin burns. Pain. Blisters. Effects could be delayed
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
 •EYES Causes watering of the eyes. Redness. Pain. Burns.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION Abdominal pain. Burning sensation. Shock or collapse.
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Personal protection: filter respirator for acid gases. Chemical protection suit. Use face shield. Consult an expert! Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.
Fireproof. Separated from food and feedstuffs, incompatible substances (see Chemical Dangers). Dry.
Do not transport with food and feedstuffs.
C symbol
R: 10-20/22-34
S: 1/2-26-36/37/39-45
UN Hazard Class: 8
UN Subsidiary Risks: 3
UN Packing Group: II
Signal: Danger
Flame-Corr-Excl mark
Flammable liquid and vapour
Harmful if swallowed
Causes severe skin burns and eye damage
Causes serious eye damage
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0209 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

ACETIC ANHYDRIDE ICSC: 0209
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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH PUNGENT ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on burning producing toxic gases and toxic fumes including acetic acid fumes . Reacts violently with alcohols, amines, oxidants, strong bases and water. Attacks many metals in presence of water or when dry.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 5 ppm as TWA (ACGIH 2006).
MAK: 5 ppm 21 mg/m
Peak limitation category: I (I) Pregnancy risk group: D
(DFG 2006).
OSHA PEL: TWA 5 ppm (20 mg/m3)
NIOSH REL: C 5 ppm (20 mg/m3)
NIOSH IDLH: 200 ppm See: 108247


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour and by ingestion .

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
Tear drawing. The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of the substance may cause asthma-like reactions.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Inhalation of the substance may cause asthma-like reactions (RADS).
PHYSICAL
PROPERTIES
Boiling point: 139C
Melting point: -73C
Relative density (water = 1): 1.08
Solubility in water: Reaction
Vapour pressure, kPa at 20C: 0.5
Relative vapour density (air = 1): 3.5
Relative density of the vapour/air-mixture at 20C (air = 1): 1.01
Flash point: 49C c.c.
Auto-ignition temperature: 316C
Explosive limits, vol% in air: 2.7-10.3
Octanol/water partition coefficient as log Pow: -0.27
ENVIRONMENTAL
DATA

N O T E S
Forms acetic acid when mixed with water. Major fires must be extinguished with large amounts of water from a distance.
Transport Emergency Card: TEC (R)-80S1715

NFPA Code: H 2; F 2; R 1; W
Card has been partially updated in July 2007: see Occupational Exposure Limits.
ADDITIONAL INFORMATION


ICSC: 0209 ACETIC ANHYDRIDE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.