International Chemical Safety Cards STRYCHNINE ICSC: 0197 Strychnidin-10-one C21H22N2O2 Molecular mass: 334.4 ICSC #    0197 CAS #     57-24-9 RTECS # WL2275000 UN #        1692 EC #         614-003-00-5 December 04, 2000 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO contact with oxidants. In case of fire in the surroundings: use appropriate extinguishing media. EXPLOSION EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION (See Ingestion). Local exhaust or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Convulsions. Muscle stiffness. Shock or collapse. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Refer for medical attention. Keep victim completely undisturbed. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Do NOT let this chemical enter the environment. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: self-contained breathing apparatus. Provision to contain effluent from fire extinguishing. Separated from strong oxidants, food and feedstuffs . Well closed. Do not transport with food and feedstuffs. Marine pollutant. T+ symbol N symbol R: 27/28-50/53 S: 1/2-36/37-45-60-61 UN Hazard Class: 6.1 UN Packing Group: I SEE IMPORTANT INFORMATION ON BACK ICSC: 0197 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards STRYCHNINE ICSC: 0197 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: ODOURLESS AND COLOURLESS CRYSTALS, WITH BITTER TASTE. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic fumes including nitrogen oxides . The substance is a weak base. Reacts with strong oxidants, causing fire and explosion hazard. OCCUPATIONAL EXPOSURE LIMITS: OSHA PEL: TWA 0.15 mg/m3 NIOSH REL: TWA 0.15 mg/m3 NIOSH IDLH: 3 mg/m3 See: 57249 TLV: 0.15 mg/m³ as TWA; (ACGIH 2004). MAK: IIb (not established but data is available) (DFG 2004). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the central nervous system , resulting in convulsions, muscle contractions, respiratory failure. Exposure may result in death. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Decomposes below boiling point Melting point: 275-285°C Density: 1.36 g/cm³ Solubility in water: none Octanol/water partition coefficient as log Pow: 1.68 ENVIRONMENTAL DATA The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment; special attention should be given to birds. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal. N O T E S Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Card has been partly updated in April 2005. See sections Occupational Exposure Limits, Emergency Response. Transport Emergency Card: TEC (R)-61GT2-I ADDITIONAL INFORMATION ICSC: 0197 STRYCHNINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.