International Chemical Safety Cards

PROPYLENE OXIDE ICSC: 0192
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
1,2-Epoxypropane
Methyloxirane
Methyl ethylene oxide
Propene oxide
C3H6O / CH3CHCH2O
Molecular mass: 58.1
3 Flammable Liquid placard ICSC #    0192
CAS #     75-56-9
RTECS # TZ2975000
UN #        1280
EC #         603-055-00-4
November 24, 2009 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Extremely flammable. Heating will cause rise in pressure with risk of bursting.
NO open flames, NO sparks, and NO smoking.
Alcohol-resistant foam, foam , water spray .
EXPLOSION Vapour/air mixtures are explosive.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
STRICT HYGIENE!

 •INHALATION Cough. Sore throat.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Seek medical attention if you feel unwell .
 •SKIN Redness.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
 •EYES Redness. Pain.
Safety goggles or eye protection in combination with breathing protection.
Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
 •INGESTION Sore throat.
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention if breathing difficulties and/or fever develop.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable dry containers. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place.
Fireproof. Separated from acids, bases and strong oxidants. Dry. Cool. Well closed. Keep in the dark. m oxidants at update 2008 due to as same as 'Chemical Danger'.; le;
Unbreakable packaging; put breakable packaging into closed unbreakable container.
Note: E

F+ symbol
T symbol
R: 45-46-12-20/21/22-36/37/38
S: 53-45
UN Hazard Class: 3
UN Packing Group: I
Signal: Danger
Flame-Excl mark-Health haz
Extremely flammable liquid and vapour
Harmful if swallowed
Harmful in contact with skin
Harmful if inhaled (vapour)
Causes skin irritation
Causes eye irritation
Suspected of causing genetic defects
Suspected of causing cancer
May cause respiratory irritation
May be harmful if swallowed and enters airways
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0192 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

PROPYLENE OXIDE ICSC: 0192
I

M

P

O

R

T

A

N

T


D

A

T

A
PHYSICAL STATE; APPEARANCE:
VERY VOLATILE COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR. coholic order),18(benzene-like order), 20(ethereal order),24;

PHYSICAL DANGERS:
The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.

CHEMICAL DANGERS:
The substance may polymerize violently under the influence of base(s), acid(s) and metal chlorides with fire or explosion hazard. Reacts violently with chlorine, ammonia, strong oxidants and acids causing fire and explosion hazard. 35,43;

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 2 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans); SEN; (ACGIH 2009).
MAK: skin absorption (H);
Carcinogen category: 2;
(DFG 2009).
(cancer) IIIA2 (1994).;2005: 13401000
OSHA PEL: TWA 100 ppm (240 mg/m3)
NIOSH REL: Ca See Appendix A
NIOSH IDLH: Ca 400 ppm See: 75569


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes , the skin and the respiratory tract . If swallowed the substance may cause vomiting, and could result in aspiration pneumonitis. of high concentrations may cause lung oedema (see Notes). rat oedema of pulmonary tissues 5000 mg/m3 4h; oedema repeated exp; t high level could cause central nervous system depression. lack of data peer review;

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis. This substance is possibly carcinogenic to humans. arc Cat 2),8(IARC 2B); ===> Carc (GHS Cat 2);
PHYSICAL
PROPERTIES
Boiling point: 34°C
Melting point: -112°C
Relative density (water = 1): 0.83
Solubility in water, g/100 ml at 20°C: 40
Vapour pressure, kPa at 20°C: 59
Relative vapour density (air = 1): 2.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.6
Flash point:
-37°C c.c.
Auto-ignition temperature: 430°C
Explosive limits, vol% in air: 1.9-36.3
Octanol/water partition coefficient as log Pow: 0.03
Viscosity, mm²/s at 25 °C: 0.34
ENVIRONMENTAL
DATA

N O T E S
Do NOT take working clothes home.
NFPA Code: H3; F4; R2
ADDITIONAL INFORMATION


ICSC: 0192 PROPYLENE OXIDE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.