International Chemical Safety Cards

MALATHION ICSC: 0172
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
Diethyl(dimethoxythiophosphorylthio)succinate
S-1,2-bis(Ethoxycarbonyl)ethyl O,O-dimethylphosphorodithioate
Butanedioic acid, {(dimethoxyphosphinothioyl)thio}-, diethyl ester
C10H19O6PS2
Molecular mass: 330.4
9 U.S. Miscellaneous placard Marine Pollutant placard ICSC #    0172
CAS #     121-75-5
RTECS # WM8400000
UN #        3082
EC #         015-041-00-X
October 19, 2005 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Foam. Powder. Carbon dioxide.
EXPLOSION


EXPOSURE
STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!

 •INHALATION Dizziness. Pupillary constriction. Muscle cramp. Excessive salivation. Sweating. Laboured breathing. Unconsciousness. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Refer for medical attention.
 •SKIN
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
 •EYES
Safety goggles or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION Abdominal cramps. Diarrhoea. Nausea. Vomiting. (Further see Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. See Chemical Dangers. Absorb remaining liquid in sand or inert absorbent and remove to safe place.
Store in an area without drain or sewer access. Separated from strong oxidants, food and feedstuffs . Keep in a well-ventilated room.
Do not transport with food and feedstuffs.
Marine pollutant.
Xn symbol
N symbol
R: 22-50/53
S: 2-24-60-61
UN Hazard Class: 9
UN Packing Group: III
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0172 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

MALATHION ICSC: 0172
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PHYSICAL STATE; APPEARANCE:
YELLOW TO BROWN LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including phosphorus oxides and sulfur oxides . Reacts violently with strong oxidants . Attacks iron and some other metals, some forms of plastic and rubber. May form the more toxic isomalathion on heating.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 1 mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2005).
MAK: (Inhalable fraction) 15 mg/m³;
Peak limitation category: II(4); Pregnancy risk group: D;
(DFG 2005).
OSHA PEL: TWA 15 mg/m3 skin
NIOSH REL: TWA 10 mg/m3 skin
NIOSH IDLH: 250 mg/m3 See: 121755


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C ; on spraying or dispersing, however, much faster.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the central nervous system , resulting in convulsions and respiratory depression . The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.
PHYSICAL
PROPERTIES
Boiling point at 0.093 kPa: 156-157°C
Melting point: 3°C
Relative density (water = 1): 1.2
Solubility in water: 145 mg/l
Vapour pressure, Pa at 30°C: negligible
Relative vapour density (air = 1): 11.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point:
163°C c.c.
Octanol/water partition coefficient as log Pow: 2.89
ENVIRONMENTAL
DATA
Environmental Hazard placard The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment; special attention should be given to honey bees. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.
N O T E S
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. If the substance is formulated with solvents also consult the ICSCs of these materials. Carrier solvents used in commercial formulations may change physical and toxicological properties.
Transport Emergency Card: TEC (R)-90GM6-III.
ADDITIONAL INFORMATION


ICSC: 0172 MALATHION
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.