International Chemical Safety Cards

DI(2,3-EPOXYPROPYL)ETHER ICSC: 0145
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
bis(2,3-Epoxypropyl)ether
Diglycidyl ether
2,2'-(Oxybis(methylene))bis-oxirane
DGE
C6H10O3 / C2H3OCH2OCH2C2H3O
Molecular mass: 130.2
ICSC #    0145
CAS #     2238-07-5
RTECS # KN2350000
September 10, 1997 Validated
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Above 64C explosive vapour/air mixtures may be formed.
Above 64C use a closed system, ventilation, and explosion-proof electrical equipment.

EXPOSURE
STRICT HYGIENE!

 •INHALATION Dizziness. Shortness of breath. Sore throat. Unconsciousness. Weakness.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Refer for medical attention.
 •SKIN MAY BE ABSORBED! Dry skin. Redness. Roughness. Skin burns. Pain. Blisters.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention if necessary.
 •EYES Redness. Pain. Blurred vision.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION Nausea. Vomiting.
Do not eat, drink, or smoke during work.
Rinse mouth. Give plenty of water to drink. Refer for medical attention.
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.
Separated from strong oxidants. Ventilation along the floor.

SEE IMPORTANT INFORMATION ON BACK
ICSC: 0145 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

DI(2,3-EPOXYPROPYL)ETHER ICSC: 0145
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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH PUNGENT ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance can presumably form explosive peroxides. May explode on heating. Reacts with strong oxidants.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.1 ppm as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK: skin absorption (H);
Carcinogen category: 3B;
(DFG 2004).
OSHA PEL: C 0.5 ppm (2.8 mg/m3)
NIOSH REL: Ca TWA 0.1 ppm (0.5 mg/m3) See Appendix A
NIOSH IDLH: Ca 10 ppm See: 2238075


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is severely irritating to the eyes , the skin and the respiratory tract . Inhalation of vapour may cause lung oedema (see Notes). The substance may cause effects on the blood, kidneys, liver, testes. Exposure could cause lowering of consciousness. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
PHYSICAL
PROPERTIES
Boiling point at 100 kPa: 260C
Relative density (water = 1): 1.26
Solubility in water: see Notes
Vapour pressure, Pa at 25C: 12
Relative vapour density (air = 1): 4.5
Relative density of the vapour/air-mixture at 20C (air = 1): 1.00
Flash point: 64C
Explosive limits, vol% in air: see Notes
ENVIRONMENTAL
DATA

N O T E S
Solubility in water, melting point, auto-ignition temperature and explosive limits are unknown in literature. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. The odour warning when the exposure limit value is exceeded is insufficient. Check for peroxides prior to distillation; eliminate if found. Card has been partly updated in April 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.
ADDITIONAL INFORMATION


ICSC: 0145 DI(2,3-EPOXYPROPYL)ETHER
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.