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ACETONITRILE

ICSC: 0088

Methyl cyanide
Cyanomethane
Ethanenitrile
Methanecarbonitrile
C2H3N / CH3CN
Molecular mass: 41.0
ICSC #    0088
CAS #     75-05-8
RTECS # AL7700000
UN #        1648
EC #         608-001-00-3
June 03, 2002 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking. NO contact with oxidants.
Alcohol-resistant foam, dry powder, carbon dioxide.
EXPLOSION Vapour/air mixtures are explosive. Risk of fire and explosion on contact with oxidants.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
STRICT HYGIENE!
IN ALL CASES CONSULT A DOCTOR!
 •INHALATION Sore throat. Weakness. Abdominal pain. Laboured breathing. Convulsions. Unconsciousness. Vomiting. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
 •SKIN Redness.
Protective gloves.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
 •EYES Redness. Pain.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION (See Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give plenty of water to drink. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Ventilation. Remove all ignition sources. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. Personal protection: complete protective clothing including self-contained breathing apparatus.
Fireproof. Separated from acids, bases and oxidants . Cool. Well closed.

F symbol
Xn symbol
R: 11-20/21/22-36
S: 1/2-16-36/37
UN Hazard Class: 3
UN Packing Group: II
ICSC: 0088 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

ACETONITRILE

ICSC: 0088

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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The vapour mixes well with air, explosive mixtures are easily formed.

CHEMICAL DANGERS:
The substance decomposes on burning producing toxic fumes including hydrogen cyanide and nitrogen oxides . Reacts with aqueous acids and bases producing toxic fumes . Reacts with strong oxidants causing fire and explosion hazard. Attacks some forms of plastic, rubber and coatings.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 20 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK: skin absorption (H);
Pregnancy risk group: C;
(DFG 2004).
EU OEL: 70 mg/m3 40 ppm as TWA (skin) (EU 2006).
OSHA PEL: TWA 40 ppm (70 mg/m3)
NIOSH REL: TWA 20 ppm (34 mg/m3)
NIOSH IDLH: 500 ppm See: 75058


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes , the skin and the respiratory tract . The substance may cause effects on the cellular respiration (inhibition) , resulting in convulsions and respiratory failure . Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:

PHYSICAL
PROPERTIES

Boiling point: 82°C
Melting point: -46°C
Relative density (water = 1): 0.8
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 9.7
Relative vapour density (air = 1): 1.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.04
Flash point: 12.8°C c.c.
Auto-ignition temperature: 524°C
Explosive limits, vol% in air: 3.0-16
Octanol/water partition coefficient as log Pow: -0.3

ENVIRONMENTAL
DATA


N O T E S

The symptoms of acute intoxication do not become manifest until after a few hours. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Card has been partly updated in October 2006: see section Occupational Exposure Limits.
Transport Emergency Card: TEC (R)-30S1648

NFPA Code: H 2; F 3; R 0;

ADDITIONAL INFORMATION



ICSC: 0088 ACETONITRILE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
 
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