International Chemical Safety Cards CHLORODIFLUOROMETHANE ICSC: 0049 Monochlorodifluoromethane Methane, chlorodifluoro- HCFC 22 R 22 CHClF2 Molecular mass: 86.5 (cylinder) ICSC #    0049 CAS #     75-45-6 RTECS # PA6390000 UN #        1018 July 03, 2002 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible under specific conditions. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. In case of fire in the surroundings: use appropriate extinguishing media. EXPLOSION In case of fire: keep cylinder cool by spraying with water. EXPOSURE  •INHALATION Cardiac arrhythmia. Confusion. Drowsiness. Unconsciousness. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN ON CONTACT WITH LIQUID: FROSTBITE. Cold-insulating gloves. ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention.  •EYES Redness. Pain. Safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Do not eat, drink, or smoke during work. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Ventilation. Fireproof. Cool. Ventilation along the floor. Special insulated cylinder. UN Hazard Class: 2.2 SEE IMPORTANT INFORMATION ON BACK ICSC: 0049 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards CHLORODIFLUOROMETHANE ICSC: 0049 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS COMPRESSED LIQUEFIED GAS PHYSICAL DANGERS: The gas is heavier than air and may accumulate in low ceiling spaces causing deficiency of oxygen. CHEMICAL DANGERS: On contact with hot surfaces or flames this substance decomposes forming toxic and corrosive gases Attacks magnesium and its alloys. OCCUPATIONAL EXPOSURE LIMITS: TLV: 1000 ppm as TWA A4 (ACGIH 2001). MAK: 500 ppm, 1800 mg/m³ Peak limitation category: II(8) Pregnancy risk group: C (DFG 2006). OSHA PEL†: none NIOSH REL: TWA 1000 ppm (3500 mg/m3) ST 1250 ppm (4375 mg/m3) NIOSH IDLH: N.D. See: IDLH INDEX ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation. INHALATION RISK: On loss of containment this gas can cause suffocation by lowering the oxygen content of the air in confined areas. EFFECTS OF SHORT-TERM EXPOSURE: Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system and central nervous system , resulting in cardiac disorders and central nervous system depression. Exposure could cause lowering of consciousness. See Notes. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: -41°C Melting point: -146°C Relative density (water = 1): 1.21 Solubility in water, g/100 ml at 25°C: 0.3 Vapour pressure, kPa at 20°C: 908 Relative vapour density (air = 1): 3.0 Auto-ignition temperature: 632°C Octanol/water partition coefficient as log Pow: 1.08 ENVIRONMENTAL DATA This substance may be hazardous to the environment; special attention should be given to its impact on the ozone layer. N O T E S High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death. Check oxygen content before entering area. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT use in the vicinity of a fire or a hot surface, or during welding. Turn leaking cylinder with the leak up to prevent escape of gas in liquid state. Freon 22, Frigen 22, Halon 22 are trade names. Transport Emergency Card: TEC (R)-20G2A Card has been partially updated in July 2007: see Occupational Exposure Limits. ADDITIONAL INFORMATION ICSC: 0049 CHLORODIFLUOROMETHANE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.