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EPICHLOROHYDRIN

ICSC: 0043

1-Chloro-2,3-epoxypropane
gamma-Chloropropylene oxide
2-(Chloromethyl)oxirane
C3H5ClO
Molecular mass: 92.5
ICSC #    0043
CAS #     106-89-8
RTECS # TX4900000
UN #        2023
EC #         603-026-00-6
November 24, 2003 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Above 31°C explosive vapour/air mixtures may be formed.
Above 31°C use a closed system, ventilation, and explosion-proof electrical equipment.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
 •INHALATION Burning sensation. Cough. Sore throat. Headache. Laboured breathing. Nausea. Shortness of breath. Vomiting. Tremor. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
 •SKIN MAY BE ABSORBED! Redness. Serious skin burns. Burning sensation. Pain. Blisters.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
 •EYES Pain. Redness. Permanent loss of vision. Severe deep burns.
Face shield, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
 •INGESTION Abdominal cramps. Burning sensation in the throat and chest. Diarrhoea. Headache. Nausea. Sore throat. Vomiting. Shock or collapse.
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Rest. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Evacuate danger area! Consult an expert! Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT let this chemical enter the environment. Chemical protection suit including self-contained breathing apparatus.
Fireproof. Separated from strong oxidants, acids, bases , aluminium , zinc , amines , food and feedstuffs . Well closed.
Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.
Note: E
T symbol
R: 45-10-23/24/25-34-43
S: 53-45
UN Hazard Class: 6.1
UN Subsidiary Risks: 3
UN Packing Group: II
ICSC: 0043 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

EPICHLOROHYDRIN

ICSC: 0043

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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance will polymerize due to heating or under the influence of strong acid(s) , base(s) . On combustion, forms toxic and corrosive fumes,hydrogen chloride (see ICSC0163)andchlorine fumes (see ICSC0126). Reacts violently with strong oxidants. Reacts violently with aluminium , zinc , alcohols , phenols, amines (especially aniline), and organic acids causing fire and explosion hazard. Attacks steel in the presence of water.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.5 ppm as TWA; (skin); A3; (ACGIH 2003).
MAK: H; Sh;
Carcinogen category: 2; Germ cell mutagen group: 3B;
(DFG 2003).
OSHA PEL: TWA 5 ppm (19 mg/m3) skin
NIOSH REL: Ca See Appendix A
NIOSH IDLH: Ca 75 ppm See: 106898


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema (see Notes). Inhalation of the vapour may cause asthma-like reactions. The substance may cause effects on the central nervous system , kidneys and liver , resulting in convulsions , kidney impairment , liver impairment . Exposure at high levels may result in death. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys , liver and lungs , resulting in impaired functions . This substance is probably carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

PHYSICAL
PROPERTIES

Boiling point: 116°C
Melting point: (see Notes) -48°C
Relative density (water = 1): 1.2
Solubility in water, g/100 ml: 6
Vapour pressure, kPa at 20°C: 1.6
Relative vapour density (air = 1): 3.2
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05
Flash point: 31°C c.c.
Auto-ignition temperature: 385°C
Explosive limits, vol% in air: 3.8-21
Octanol/water partition coefficient as log Pow: 0.26

ENVIRONMENTAL
DATA

The substance is harmful to aquatic organisms.

N O T E S

Other melting points: -25.6 °C and -57°C. Depending on the degree of exposure, periodic medical examination is indicated. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home.
Transport Emergency Card: TEC (R)-61S2023

NFPA Code: H3; F3; R2;

ADDITIONAL INFORMATION



ICSC: 0043 EPICHLOROHYDRIN
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
 
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