International Chemical Safety Cards

1,4-DIOXANE ICSC: 0041
World Health Organization (WHO) International Labour Organization (ILO) United Nations Environmental Programme (UNEP) European Commission National Institute for Occupational Safety and Health (NIOSH)
1,4-Diethylene dioxide
Dioxane
para-Dioxane
C4H8O2
Molecular mass: 88.1
3 Flammable Liquid placard ICSC #    0041
CAS #     123-91-1
RTECS # JG8225000
UN #        1165
EC #         603-024-00-5
November 11, 2008 Validated
Pu, hed in Series 1.
TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking. NO contact with strong oxidants. NO contact with hot surfaces.
Powder, alcohol-resistant foam, water spray, carbon dioxide water may be ineffective: water spray: OK;
EXPLOSION Vapour/air mixtures are explosive. Risk of fire and explosion on contact with incompatible materials: see Chemical Dangers.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT GENERATION OF MISTS!

 •INHALATION Cough. Sore throat. Nausea. Dizziness. Headache. Drowsiness. Vomiting. Unconsciousness. Abdominal pain.
Ventilation (not if powder), local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention immediately.
 •SKIN MAY BE ABSORBED!
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
 •EYES Redness. Pain. es watering of the eyes. at update 2007 due to eye irritation;
Face shield or eye protection in combination with breathing protection.
Rinse with plenty of water (remove contact lenses if easily possible).
 •INGESTION (See Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Seek medical attention if you feel unwell om Refer for medical attention. at update 2007.;
SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable air tight containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. m Collect leaking and spilled liquid in sealable containers as far as possible. at update 2007;
Fireproof. Separated from strong oxidants , strong acids, and incompatible materials . Cool. Dry. Well closed. Keep in the dark. Store only if stabilized. Store in an area without drain or sewer access. m strong acids. at update2007;
Airtight.
Note: D
F symbol
Xn symbol
R: 11-19-36/37-40-66
S: 2-9-16-36/37-46
UN Hazard Class: 3
UN Packing Group: II
Signal: Danger
Flame-Excl mark-Health haz
Highly flammable liquid and vapour
Causes eye irritation
May cause respiratory irritation
Suspected of causing cancer
May be harmful if swallowed and enters airways
SEE IMPORTANT INFORMATION ON BACK
ICSC: 0041 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

1,4-DIOXANE ICSC: 0041
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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The vapour is heavier than air and may travel along the ground; distant ignition possible.

CHEMICAL DANGERS:
The substance can form explosive peroxides on contact with air. Reacts with oxidants and strong acids. Reacts violently with some catalysts. hanged from Reacts vigorously with strong oxidants and concentrated strong acids. at update 2007; , Replace from Reacts explosively with some catalysts (e.g., Raney-nickel above 210C). at update 2007; acks many plastics. at update 2007 due to no info;

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 20 ppm as TWA; (skin) A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2008).
MAK: 20 ppm, 73 mg/m;
Peak limitation category: I(2);
skin absorption (H);
Carcinogen category: 4; Pregnancy risk group: C;
(DFG 2008).
OSHA PEL: TWA 100 ppm (360 mg/m3) skin
NIOSH REL: Ca C 1 ppm (3.6 mg/m3) 30-minute See Appendix A
NIOSH IDLH: Ca 500 ppm See: 123911


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour and through the skin.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20C; on spraying or dispersing, however, much faster. m free phrase of 'on spraying much faster' at update 2007.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes and the respiratory tract . If swallowed the substance may cause vomiting, and could result in aspiration pneumonitis. Exposure at high levels could cause lowering of consciousness. 46; m Exposure to high vapour concentrations may result in unconsciousness. at update 2007.;

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The liquid defats the skin. The substance may have effects on the central nervous system, kidneys, and liver. This substance is possibly carcinogenic to humans. p 2B), Changed from This substance is probably carcinogenic to humans. at update 2007.
PHYSICAL
PROPERTIES
Boiling point: 101C
Melting point: 12C
Relative density (water = 1): 1.03
Solubility in water:
miscible
Vapour pressure, kPa at 20C: 3.9
Relative vapour density (air = 1): 3.0
Relative density of the vapour/air-mixture at 20C (air = 1): 1.08
Flash point:
12C c.c.
Auto-ignition temperature: 180C
Explosive limits, vol% in air: 2.0-22.0
Octanol/water partition coefficient as log Pow: -0.27
Viscosity, mm2/s at 25 C: 1.17
ENVIRONMENTAL
DATA

N O T E S
Check for peroxides prior to distillation; eliminate if found. Refer for medical attention if breathing difficulties and/or fever develop. .83(24ppm from Appendix 6); Other OSF=20/170=0.12(170 ppm at update 2007, i.e., changed from Check for peroxides prior to distillation; render harmless if positive.;
Transport Emergency Card: TEC (R)-30S1165 or 30GF1-I+II

NFPA Code: H2, F3, R1

ADDITIONAL INFORMATION


ICSC: 0041 1,4-DIOXANE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.