International Chemical Safety Cards p-CRESOL ICSC: 0031 4-Hydroxy-1-methylbenzene 4-Methylphenol para-Hydroxytoluene 4-Cresol C7H8O / CH3C6H4OH Molecular mass: 108.1 ICSC #    0031 CAS #     106-44-5 RTECS # GO6475000 UN #        3455 EC #         604-004-00-9 November 13, 2008 Validated TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Water spray, foam, powder, carbon dioxide. EXPLOSION Above 86°C explosive vapour/air mixtures may be formed. Above 86°C use a closed system, ventilation. EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Cough. Sore throat. Burning sensation. Headache. Nausea. Vomiting. Shortness of breath. Laboured breathing. Local exhaust or breathing protection. Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer immediately for medical attention.  •SKIN MAY BE ABSORBED! Redness. Pain. Blisters. Skin burns. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.  •EYES Redness. Pain. Severe deep burns. Face shield or eye protection in combination with breathing protection. Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention  •INGESTION Burns in mouth and throat. Burning sensation in the throat and chest. Nausea. Vomiting. Abdominal pain. Shock or collapse. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance . Chemical protection suit. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. Separated from strong oxidants, food and feedstuffs . Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Do not transport with food and feedstuffs. Marine pollutant. Note: C T symbol C symbol R: 24/25-34 S: 1/2-36/37/39-45 UN Hazard Class: 6.1 UN Subsidiary Risks: 8 UN Packing Group: II Signal: Danger Corr-Skull-Health haz Toxic if swallowed Toxic in contact with skin Fatal if inhaled vapour Causes severe skin burns and eye damage Causes damage to the central nervous system and blood cells Causes damage to nervous system and blood cells through prolonged or repeated exposure Toxic to aquatic life SEE IMPORTANT INFORMATION ON BACK ICSC: 0031 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards p-CRESOL ICSC: 0031 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS , WITH CHARACTERISTIC ODOUR. TURNS DARK ON EXPOSURE TO AIR AND LIGHT . PHYSICAL DANGERS: CHEMICAL DANGERS: Reacts violently with strong oxidants . The solution in water is a weak acid. OCCUPATIONAL EXPOSURE LIMITS: TLV: 5 ppm as TWA (skin) (ACGIH 2008). MAK: skin absorption (H); Carcinogen category: 3A; BAT issued; (DFG 2008). tions for the allocation into the category 4 or 5 would be fulfilled but there is not enough information to derive a MAK-value. OSHA PEL: TWA 5 ppm (22 mg/m3) skin NIOSH REL: TWA 2.3 ppm (10 mg/m3) NIOSH IDLH: 250 ppm See: cresol ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Serious local effects by all routes of exposure. INHALATION RISK: A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. The substance may cause effects on the central nervous system , resulting in lowering of consciousness. The substance may cause effects on the blood , resulting in destruction of blood cells. Exposure far above the OEL may result in death . Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the nervous system , resulting in impaired functions. The substance may have effects on the blood , resulting in anaemia. PHYSICAL PROPERTIES Boiling point: 202°C Melting point: 35°C Density: 1.02 g/cm³ Solubility in water, g/100 ml at 25°C: 1.9 (moderate) Vapour pressure, Pa at 25°C: 15 Relative vapour density (air = 1): 3.7 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 86°C c.c. Auto-ignition temperature: 555°C Explosive limits, vol% in air: 1.0-? Octanol/water partition coefficient as log Pow: 1.94 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. It is strongly advised that this substance does not enter the environment. N O T E S Transport Emergency Card: TEC (R)-61GTC2-II NFPA Code: H 3; F 2; R 0; ADDITIONAL INFORMATION ICSC: 0031 p-CRESOL (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.