Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
CAS number: 7722–84–1
NIOSH REL: 1 ppm (1.4 mg/m3) TWA
Current OSHA PEL: 1 ppm (1.4 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 1 ppm (1.4 mg/m3) TWA
Description of Substance: Colorless liquid with a slightly sharp odor.
LEL:. . Noncombustible Liquid
Original (SCP) IDLH: 75 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by AIHA  that the short exposure tolerance is unknown for man, but is probably 75 ppm. AIHA  also reported that a single 4hour exposure to 75 ppm was tolerated by mice but higher concentrations produced delayed deaths [Svirbely]. According to AIHA , concentrations in excess of 1,000 ppm would probably be lethal after a few minutes [Svirbely].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Rat||Gig Tr Prof Zabol 1977||1,418||-----||4 hr||2,836 ppm (2.0)||284 ppm|
|Mouse||Stokinger & Scheel 1962||-----||227||?||?||?|
Lethal dose data:
|Adjusted LD||Derived value|
|Mouse||Lyazsky et al. 1983||oral||2,000||-----||9,929 ppm||993 ppm|
Other animal data: It has been reported that mice tolerated a single 4hour exposure to 75 ppm [Svirbely].
Human data: It has been stated that although the shortterm
exposure tolerance is unknown, it is probably about 75 ppm
[AIHA 1957]. Death has resulted in a man who drank 100 ml
[Raukhverger and Solodko 1974].
|Revised IDLH: 75 ppm [Unchanged]
Basis for revised IDLH: Based on acute inhalation data in humans [AIHA 1957] and animals [Svirbely], the original IDLH for hydrogen peroxide (75 ppm) is not being revised at this time.
1. AIHA . Hydrogen peroxide (90%). In: Hygienic guide series. Am Ind Hyg Assoc Q 18:275276.
2. Gig Tr Prof Zabol ; 21(10):2225 (in Russian).
3. Lyazsky PP, Gleiberman SE, et al. . Toxicological and hygienic characterization of decontaminating preparations based on hydrogen peroxide and its derivatives. Gig Sanit 48(6):2831 (in Russian).
4. Raukhverger AB, Solodko ON . Intoxication with concentrated hydrogen peroxide. SudebnoMeditsinkaya Ekspertiza (Forensic Medical Examination) 17(1):5354 (in Russian).
5. Stokinger HE, Scheel LD . Ozone toxicity: immunochemical and toleranceproducing aspects. Arch Environ Health 4:327334.
6. Svirbely JL [?]. Unpublished results. Cincinnati, OH: U.S.
Public Health Service. [From AIHA . Hydrogen peroxide (90%).
In: Hygienic guide series. Am Ind Hyg Assoc Q 18:275276.]
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