Allyl Glycidyl Ether
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 106-92-3
NIOSH REL: 5 ppm (22 mg/m3) TWA, 10 ppm (44 mg/m3) STEL [skin]
Current OSHA PEL: 10 ppm (45 mg/m3) CEILING
1989 OSHA PEL: 5 ppm (22 mg/m3) TWA, 10 ppm (44 mg/m3) STEL
1993-1994 ACGIH TLV: 5 ppm (23 mg/m3) TWA, 10 ppm (47 mg/m3) STEL
Description of substance: Colorless liquid with a pleasant odor.
LEL: Unknown
Original (SCP) IDLH: 270 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC50 of 270 ppm [Hine et al. 1956] cited in ACGIH [1971], AIHA [1965], and Patty [1963].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Adjusted | ||||||
|---|---|---|---|---|---|---|
| LC50 | LCLo | 0.5-hr | Derived | |||
| Species | Reference | (ppm) | (ppm) | Time | LC (CF) | Value |
| Mouse | Hine et al. 1956 | 270 | ----- | 4 hr | 540 ppm (2.0) | 54 ppm |
| Rat | Hine et al. 1956 | 670 | ----- | 8 hr | 1,675 ppm (2.5) | 168 ppm |
Human data: None relevant for determining the revised IDLH.
Revised IDLH: 50 ppm Basis for revised IDLH: The revised IDLH for allyl glycidyl ether is 50 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers. |
References:
- ACGIH [1971]. Allyl glycidyl ether. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 9.
- AIHA [1965]. Allyl glycidyl ether. In: Hygienic guide series. Am Ind Hyg Assoc J 26:89-91.
- Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.
- Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1599.