Allyl glycidyl ether

CAS number: 106-92-3

NIOSH REL: 5 ppm (22 mg/m3) TWA, 10 ppm (44 mg/m3) STEL [skin]

Current OSHA PEL: 10 ppm (45 mg/m3) CEILING

1989 OSHA PEL: 5 ppm (22 mg/m3) TWA, 10 ppm (44 mg/m3) STEL

1993-1994 ACGIH TLV: 5 ppm (23 mg/m3) TWA, 10 ppm (47 mg/m3) STEL

Description of substance: Colorless liquid with a pleasant odor.

LEL: Unknown

Original (SCP) IDLH: 270 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC50 of 270 ppm [Hine et al. 1956] cited in ACGIH [1971], AIHA [1965], and Patty [1963].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:
  Adjusted  
  LC50 LCLo   0.5-hr Derived
Species Reference (ppm) (ppm) Time LC (CF) Value
Mouse Hine et al. 1956 270 ----- 4 hr 540 ppm (2.0) 54 ppm
Rat Hine et al. 1956 670 ----- 8 hr 1,675 ppm (2.5) 168 ppm

Human data: None relevant for determining the revised IDLH.

Revised IDLH: 50 ppm

Basis for revised IDLH: The revised IDLH for allyl glycidyl ether is 50 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

References:

  1. ACGIH [1971]. Allyl glycidyl ether. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 9.
  2. AIHA [1965]. Allyl glycidyl ether. In: Hygienic guide series. Am Ind Hyg Assoc J 26:89-91.
  3. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.
  4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1599.

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