Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
Ethyl butyl ketone
CAS number: 106–35–4
NIOSH REL: 50 ppm (230 mg/m3) TWA
Current OSHA PEL: 50 ppm (230 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 50 ppm (234 mg/m3) TWA
Description of Substance: Colorless liquid with a powerful, fruity odor.
LEL:. . Unknown
Original (SCP) IDLH: 3,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Patty  and Deichmann and Gerarde  that 0 rats died following a 4-hour exposure to 2,000 ppm, but 6 of 6 rats died following a 4-hour exposure to 4,000 ppm [Smyth et al. 1949].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Rat||Smyth et al. 1949||LC100: 4,000||-----||4 hr||8,000 ppm (2.0)||800 ppm|
Lethal dose data:
|Rat||Smyth et al. 1949||oral||2,760||-----||4,067 ppm||408 ppm|
Other animal data: It has been reported that rats survived a 4-hour exposure to 2,000 ppm [Smyth et al. 1949].
Human data: None relevant for use in determining the revised IDLH.
|Revised IDLH: 1,000 ppm
Basis for revised IDLH: The revised IDLH for ethyl butyl ketone is 1,000 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].
1. Deichmann WB, Gerarde HW . Table 50. Toxicity of ketones. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 736.
2. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1741.
3. Smyth HF Jr, Carpenter CP, Weil CS . Range-finding
toxicity data: list III. J Ind Hyg Toxicol 31:60-62.
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