NIOSH Docket Number 273, CDC-2014-0006
Request for comments on NIOSH draft method 8324 (3-Bromopropionic acid in urine; A metabolite of 1-bromopropane)
The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) intends to publish a new method in the NIOSH Manual of Analytical Methods (NMAM). This method is entitled "Method 8324: 3-Bromopropionic acid in urine; A metabolite of 1-bromopropane."
1-Bromopropane is an industrial solvent often used as a substitute for a number of chlorofluorocarbon solvents which have been withdrawn from use because of their possible damaging effects to the ozone layer. 3-Bromopropionic acid is a human metabolite of 1-bromopropane and a proposed biomarker of exposure. An accurate and precise method was developed for the detection and quantitation of 3-bromopropionic acid in human urine. This method has been published in the literature (B'Hymer CB, Cheever KL . J Chromatogr B 802:361-366). The method has been further validated by a second laboratory and is proposed for inclusion in NMAM's 5th Edition.
To view the notice and related materials, visit http://www.regulations.gov and enter CDC-2014-0006 in the search field and click "Search."
Federal Register Notice:
Public Comment Period
Comments will be accepted until 5:00 p.m. EST on June 10, 2014.
Written comments, identified by CDC-2014-0006 and docket number NIOSH-273, may be submitted by any of the following methods:
Federal rulemaking portal: Follow the instructions for submitting comments.
Instructions: All submissions received must include the agency name and docket number. All relevant comments, including any personal information provided, will be posted without change to http://www.regulations.gov
- Mail: NIOSH Docket Office
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