Skin Notation Strategy

Historically, skin notations have been published in the NIOSH Pocket Guide to Chemical Hazards. This practice will continue with the NIOSH skin notation assignments for each evaluated chemical being integrated as they become available. A support document called a Skin Notation Profile has been developed for each evaluated chemical. The Skin Notation Profile for a chemical is intended to provide information supplemental to the skin notation, including a summary of all relevant data used to aid in determining the hazards associated with skin exposures.

NIOSH obtained comments on the draft skin notation assignments and Skin Notation Profiles for 22 chemicals. The submissions are listed below.

Note: To view the final Skin Notation Profiles visit the Skin Notation Profiles website .

Background Information

Revised Final Document: NIOSH Current Intelligence Bulletin (CIB): 61: A strategy for Assigning New NIOSH Skin Notations – 8/1/17 [PDF – 2 MB]

Final document: NIOSH Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations; 2009-147 – 7/1/09

Peer reviewer summary of comments – 06/01/10 [PDF – 3,712 KB]

Notice of public comment period; 75 FR 22148 – 04/27/10 [PDF – 3,628 KB]

Charge to Reviewers – 04/27/10 [PDF – 1,287 KB]

Peer Reviewer Submissions on 22 Chemicals (in Numerical Order)

• A-01 1, 3-Dichloropropene (CAS # 542–75–6): Submission to the docket from peer reviewers on 1,3-Dichloropropene – 06/01/10 [PDF – 3,483 KB]
• A-02 Phenol (CAS # 108–95–2): Submission to the docket from peer reviewers on Phenol – 06/01/10 [PDF – 2,381 KB]
• A-03 Hydrogen fluoride/hydrofluoric acid (CAS # 7664–39–3): Submission to the docket from peer reviewers on Hydrogen fluoride/hydrofluoric acid – 06/01/10 [PDF – 2,552 KB]
• A-04 Dinitrotoluene (CAS # 25321–14–6); 2,4–; (CAS # 121–14–2); 2,6–; (CAS # 606–20–2): Submission to the docket from peer reviewers on Dinitrotoluene – 06/01/10 [PDF – 4,410 KB]
• A-05 Acrylamide (CAS # 79–06–1): Submission to the docket from peer reviewers on Acrylamide – 06/01/10 [PDF – 1,516 KB]
• A-06 Acrylonitrile (CAS # 107–13–1): Submission to the docket from peer reviewers on Acrylonitrile – 06/01/10 [PDF – 1,673 KB]
• A-07 Metallic Chromium and other Substances containing Hexavalent Chromium [Cr(VI)] CAS # 7440–47–3; 18540–29–9: Submission to the docket from peer reviewers on Metallic Chromium and other Substances containing Hexavalent Chromium (Cr(VI)) – 06/01/10 [PDF – 3,095 KB]
• A-08 m,p,o-Dinitrobenzene (CAS # 99–65–0; 58–29–0; 100–25–4): Submission to the docket from peer reviewers on m,p,o-Dinitrobenzene – 06/01/10 [PDF – 2,327 KB]
• A-09 Epichlorohydrin (CAS # 106–89–8): Submission to the docket from peer reviewers on Epichlorohydrin – 06/01/10 [PDF – 1,971 KB]
• A-10 Ethylene glycol dinitrate (CAS # 628–96–6): Submission to the docket from peer reviewers on Ethylene glycol dinitrate – 06/01/10 [PDF – 2,642 KB]
• A-11 Bisphenol A (CAS # 80–05–7): Submission to the docket from peer reviewers on Bisphenol A – 06/01/10 [PDF – 2,428 KB]
• A-12 Formaldehyde (CAS # 50–00–0): Submission to the docket from peer reviewers on Formaldehyde – 06/01/10 [PDF – 3,426 KB]
• A-13 Hydrazine (CAS # 302–01–2): Submission to the docket from peer reviewers on Hydrazine – 06/01/10 [PDF – 2,343 KB]
• A-14 Nitroglycerin (CAS # 55–63–0): Submission to the docket from peer reviewers on Nitroglycerin – 06/01/10 [PDF – 2,461 KB]
• A-15 Nonane (CAS # 111–84–2): Submission to the docket from peer reviewers on Nonane – 06/01/10 [PDF – 1,937 KB]
• A-16 Glutaraldehyde (CAS # 111–30–8): Submission to the docket from peer reviewers on Glutaraldehyde – 06/01/10 [PDF – 2,556 KB]
• A-17 Sodium hydroxide (CAS # 1310–73–2): Submission to the docket from peer reviewers on Sodium hydroxide – 06/01/10 [PDF – 2,354 KB]
• A-18 Trichloroethylene (CAS # 79–01–6): Submission to the docket from peer reviewers on Trichloroethylene – 06/01/10 [PDF – 3,277 KB]
• A-19 Methyl cellosolve (CAS # 109–86–4): Submission to the docket from peer reviewers on Methyl cellosolve – 06/01/10 [PDF – 2,958 KB]
• A-20 2-Butoxyethanol (CAS # 111–76–2): Submission to the docket from peer reviewers on 2-Butoxyethanol – 06/01/10 [PDF – 2,619 KB]
• A-21 2-Ethoxyethanol (CAS # 110–80–5): Submission to the docket from peer reviewers on 2-Ethoxyethanol – 06/01/10 [PDF – 2,055 KB]
• A-22 p-Phenylenediamine (CAS # 106–50–3): Submission to the docket from peer reviewers on p-Phenylenediamine – 06/01/10 [PDF – 1,920 KB]

Submissions in Numerical Order

Submission to Docket Office from Kristy Morrison (American Chemistry Council) on A-03; 06/11/10 [PDF – 2,153 KB]

Submission to Docket Office from Markku Huvienen and Grant Darrie (International Chromium Development Association) on A-07; 05/12/10 [PDF – 2,941 KB]

Submission to Docket Office from John Wittenborn (Counsel to the Specialty Steel Industry of North American) on A-07; 06/10/10 [PDF – 2,443 KB]

Submission to Docket Office from Paul Dugard (Halogenated Solvents Industry Alliance Inc) on A-18; w/3 attachments; 06/11/10 [PDF – 1,922 KB]

Attachment 1-HLA-B*1301 as a Biomarker for Genetic Susceptibility to Hypersensitivity Dermatitis Induced by Trichloroethylene among Workers in China;11/01/07 [PDF – 5,507 KB]

Attachment 2-Hepatitis, Rash and Eosinophilia Following Trichloroethylene Exposure: A Case Report and Speculation on Mechanistic Similarity to Halothane Induced Hepatitis;01/01/96 [PDF – 5,946 KB]

Attachment 3-Occupational Trichloroethylene Exposure as a Cause of Idiosyncratic Generalized Skin Disorders and Accompanying Hepatitis Similar to Drug Hypersensitivities;01/01/0 [PDF – 16,005 KB]

Peer review

Title: NIOSH Skin Notation (SK) Profiles: Group A (22 Technical Reports)

Subject: Technical assessment of the potential hazards of skin contact with chemicals and assignment of hazard-specific skin notations (SK) based on review.

Purpose: To assess the potential hazards of skin contact with selected chemicals following the decision logic and strategy presented in NIOSH Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009-147] and develop hazard-specific skin notation (SK) assignments based on the critical review of available scientific data.

Type of Dissemination: Printed document and web posting.

Timing of Review: May-July 2010

Primary Disciplines or Expertise Needed for Review: Human health risk assessment, toxicology, epidemiology, industrial hygiene, health sciences

Type of Review: Individual

Number of Reviewers: 24, 2 of those assigned to each technical report

Reviewers Selected by: NIOSH

Public Nominations Requested for Reviewers: No

Opportunities for the Public to Comment: Yes

Peer Reviewers Provided with Public Comments before Their Review: Yes

Peer Reviewers

1. Bryan E. Anderson
   Academic and Professional Credentials: MD
   Organizational Affiliation: Assistant Professor, Department of Dermatology
   Penn State College of Medicine, Hersey. PA
   Areas of Expertise, Discipline, or Relevant Experience: Dermatology
   Recommended by: NIOSH
2. Ronald Baynes
   Academic and Professional Credentials: MD
   Organizational Affiliation: Associate Professor, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
   Areas of Expertise, Discipline, or Relevant Experience: Pharmacology
   Recommended by: NIOSH
3. Frank Barile
   Academic and Professional Credentials: PhD
   Organizational Affiliation: Professor, Epidemiology, Department of Pharmaceutical Sciences, St. Johns University, Queens, NY
   Areas of Expertise, Discipline, or Relevant Experience: Toxicology/Pharmacology
   Recommended by: NIOSH
4. Phillip J. Bigelow
   Academic and Professional Credentials: PhD, CIH
   Organizational Affiliation: Associate Professor, Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Canda
   Areas of Expertise, Discipline, or Relevant Experience: Pharmacology
   Recommended by: NIOSH
5. John Cherrie
   Academic and Professional Credentials: PhD
   Organizational Affiliation: Research Director, Institute of Occupational Medicine, Edinburgh, Scotland
   Areas of Expertise, Discipline, or Relevant Experience: Industrial Hygiene, Exposure Assessment
   Recommended by: NIOSH
6. Laura Deakin
   Academic and Professional Credentials: PhD
   Organizational Affiliation: Associate Professor, Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada
   Areas of Expertise, Discipline, or Relevant Experience: Chemistry, Public Health
   Recommended by: NIOSH
7. Joshua Gray
   Academic and Professional Credentials: PhD
   Organizational Affiliation: Associate Professor, Department of Pharmacology & Toxicology, Rutgers University, New London, CT
   Areas of Expertise, Discipline, or Relevant Experience: Dermal Toxicology
   Recommended by: NIOSH
8. Diane E. Heck
   Academic and Professional Credentials: PhD
   Organizational Affiliation: Professor and Chair, Department of Environmental Health Science, School of Health Sciences and Practice, New York Medical College, Valhalla, NY
   Areas of Expertise, Discipline, or Relevant Experience: Toxicology
   Recommended by: NIOSH
9. John Herbold
   Academic and Professional Credentials: PhD
   Organizational Affiliation: School of Public Health, University of Texas, San Antonio, TX
   Areas of Expertise, Discipline, or Relevant Experience: Toxicology, Epidemiology
   Recommended by: NIOSH
10. Randal J. Keller
    Academic and Professional Credentials: PhD, CIH, CSP,DABT
    Organizational Affiliation: Professor, Department of Occupational Safety and Health, Murray State University, Murray, KY
    Areas of Expertise, Discipline, or Relevant Experience: Toxicology, Industrial Hygiene
    Recommended by: NIOSH
11. Youcheng Liu
    Academic and Professional Credentials: MD, ScD, MPH
    Organizational Affiliation: Assistant Professor, Department of Preventive Medicine and Environmental Health College of Public Health, University of Kentucky, Lexington, KY
    Areas of Expertise, Discipline, or Relevant Experience: Exposure Assessment, Industrial Hygiene
    Recommended by: NIOSH
12. William E. Luttrell
    Academic and Professional Credentials: PhD, CIH
    Organizational Affiliation: Associate Professor of Chemistry and Chair, Department of Chemistry and Physics, Oklahoma Christian University, Edmond, Oklahoma
    Areas of Expertise, Discipline, or Relevant Experience: Exposure Assessment, Industrial Hygiene
    Recommended by: NIOSH
13. Howard Maibach
    Academic and Professional Credentials: PhD
    Organizational Affiliation: Professor, Department of Dermatology, University of California-San Francisco, San Francisco, CA
    Areas of Expertise, Discipline, or Relevant Experience: Dermatology, Dermal Toxicology
    Recommended by: NIOSH
14. James N. McDougal
    Academic and Professional Credentials: PhD
    Organizational Affiliation: Professor and Director of Toxicology Research, Department of Pharmacology and Toxicology, Wright State University, Dayton, OH
    Areas of Expertise, Discipline, or Relevant Experience: Dermal Toxicology
    Recommended by: NIOSH
15. Nancy Monterio-Riviere
    Academic and Professional Credentials: PhD
    Organizational Affiliation: Professor, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC
    Areas of Expertise, Discipline, or Relevant Experience: Dermal Toxicology
    Recommended by: NIOSH
16. Hasan Mukhtar
    Academic and Professional Credentials: PhD
    Organizational Affiliation: Professor, Department of Dermatology, University of Wisconsin, Madison, Wisconsin
    Areas of Expertise, Discipline, or Relevant Experience: Dermal Pharmacology, Dermal Toxicology
    Recommended by: NIOSH
17. Alfred M. Nyanda
    Academic and Professional Credentials: PhD
    Organizational Affiliation: Professor, Department of Medical & Professional Education, Meharry Medical College, Nashville, TN
    Areas of Expertise, Discipline, or Relevant Experience: Pharmacology
    Recommended by: NIOSH
18. Leena Nyanda-French
    Academic and Professional Credentials: PhD, CIH
    Organizational Affiliation: Professor, Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC
    Areas of Expertise, Discipline, or Relevant Experience: Industrial Hygiene, Exposure Assessment
    Recommended by: NIOSH
19. Mai A. Ngo
    Academic and Professional Credentials: PhD
    Organizational Affiliation: Researcher, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA
    Areas of Expertise, Discipline, or Relevant Experience: Dermal Toxicology
    Recommended by: NIOSH
20. Shane S. Que Hee
    Academic and Professional Credentials: PhD
    Organizational Affiliation: Professor, Department of Environmental Health Sciences, School of Public Health, University of California-Los Angeles, Los Angeles, CA
    Areas of Expertise, Discipline, or Relevant Experience: Environmental Health Sciences, Industrial Hygiene
    Recommended by: NIOSH
21. Gloria Post
    Academic and Professional Credentials: PhD, DABT
    Organizational Affiliation: Research Scientist, Office of Science, New Jersey Department of Environmental Protection, Trenton, NJ
    Areas of Expertise, Discipline, or Relevant Experience: Toxicology
    Recommended by: NIOSH
22. Jim E. Riviere
    Academic and Professional Credentials: DVM, PhD, DSc, ATS
    Organizational Affiliation: Professor and Director, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, Raleigh, NC
    Areas of Expertise, Discipline, or Relevant Experience: Toxicology, Pathobiology
    Recommended by: NIOSH
23. Carrie Redlich
    Academic and Professional Credentials: MD, MPH
    Organizational Affiliation: Yale Occupational and Environmental Medicine Program, School of Medicine, Yale University, New Haven, CT
    Areas of Expertise, Discipline, or Relevant Experience: Occupational Medicine
    Recommended by: NIOSH
24. Katherine S. Squibb
    Academic and Professional Credentials: PhD
    Organizational Affiliation: Professor of Medicine, University of Maryland School of Medicine, Baltimore, MD
    Areas of Expertise, Discipline, or Relevant Experience: Toxicology
    Recommended by: NIOSH