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Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc, bis(dimethyldithiocarbamato)-

RTECS #

ZH0525000

CAS #

137-30-4; 8059-74-3; 8070-07-3; 12768-61-5; 12773-04-5; 14459-91-7; 17125-91-6; 31300-71-7; 55870-88-7; 98391-07-2; 111922-61-3

Updated

April 2013

Molecular Weight

305.81

Molecular Formula

C6H12N2S4·Zn

Synonyms

Aaprotect
Aavolex
Aazira
Accelerator L
Aceto ZDED
Alcobam ZM
Bis(dimethylcarbamodithioato-S,S')zinc
Bis(dimethyldithiocarbamato)zinc
Bis(N,N-dimetil-ditiocarbammato) di zinco (Italian)
Bis-dimethyldithiocarbamate de zinc (French)
Carbamic acid, dimethyldithio-, zinc salt (2:1)
Carbazinc
Corona corozate
Corozate
Cuman
Cuman L
Cymate
Dimethylcarbamodithioic acid, zinc complex
Dimethylcarbamodithioic acid, zinc salt
Dimethyldithiocarbamate zinc salt
Dimethyldithiocarbamic acid, zinc salt
Drupina 90
ENT 988
Eptac 1
Fuclasin
Fuclasin Ultra
Fuklasin
Fungostop
Hermat ZDM
Hexazir
Karbam White
Methasan
Methazate
Methyl zimate
Methyl zineb
Methyl Ziram
Mezene
Milbam
Molurame
Mycronil
NCI-C50442
Orchard brand ziram
Pomarsol Z forte
Prodaram
Rhodiacid
Soxinal PZ
Soxinol PZ
Tricarbamix Z
Triscabol
Tsimat
Tsiram (Russian)
USAF P-2
Vancide MZ-96
Vulcacure ZM
Vulkacit L
Vulkacite L
Z 75
Zarlate
Z-C spray
ZDMC
Zerlate
Zimate
Zinc bis(dimethyldithiocarbamate)
Zinc bis(dimethyldithiocarbamoyl)disulphide
Zinc bis(dimethylthiocarbamoyl)disulfide
Zinc dimethyldithiocarbamate
Zinc N,N-dimethyldithiocarbamate
Zink-(N,N-dimethyl-dithiocarbamat) (German)
Zink-bis(N,N-dimethyl-dithiocarbamaat) (Dutch)
Zink-bis(N,N-dimethyl-dithiocarbamat) (German)
Ziradin
Ziram
Ziram technical
Ziramvis
Zirasan
Zirasan 90
Zirberk
Zirex 90
Ziride
Zirthane
Zitox

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human10 nmol/LTXCYAC 4,331,1975
Cytogenetic Analysisoral/mouse1750 mg/kg/5D-continuousMUREAV 208,57,1988
Cytogenetic Analysisovary/hamster25 µg/LSCIEAS 236,933,1987
DNA Damageintraperitoneal/rat50 mg/kgMUREAV 302,1,1993
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
DNA inhibitionother cell types/rat100 µg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human1 mg/LARTODN 45,101,1980
DNA repair/Bacillus subtilis600 ng/discMUREAV 40,19,1976
micronucleus testunreported route/mouse350 mg/kg/24HMUREAV 208,57,1988
micronucleus testlymphocyte/human10 mg/L/21H (-enzymatic activation step)MUREAV 497,89,2001
morphological transformfibroblast/mouse1 µg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in mammalian somatic cellslymphocyte/mouse62500 ng/LEMMUEG 12,85,1988
mutation in microorganisms/Salmonella typhimurium10 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium5 µg/plate (+/-enzymatic activation step)MUREAV 68,313,1979
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster500 mg/LSWEHDO 9(Suppl 2),27,1983
sister chromatid exchangeovary/hamster25 µg/LEMMUEG 13,133,1989
specific locus testoral/Drosophila melanogaster130 ppmMUREAV 224,161,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EESADV 7,531,1983
oral/rat 250 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)EESADV 7,531,1983
oral/rat 1 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) systemEESADV 7,531,1983
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)EESADV 7,531,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 60 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
VPITAR 29,71,1970
oral/mouse lowest published toxic dose: 840 mg/kg/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GISAAA 37(9),25,1972
oral/mouse lowest published toxic dose: 87962 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB83-202622
oral/mouse lowest published toxic dose: 178808 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB83-202622
oral/rat lowest published toxic dose: 12978 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-238,1982
oral/rat toxic dose: 25956 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-238,1982
oral/rat toxic dose: 13160 mg/kg/94W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
VPITAR 29,71,1970
oral/rat lowest published toxic dose: 7931 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB83-202622

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): >1056 mg/m3/2HEye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 12(4),12,1968
inhalation/rat lethal concentration (50 percent kill): 26 mg/m3/2HNTIS** OTS0540394
intraperitoneal/guinea pig lowest published lethal dose: 30 mg/kgBehavioral: ComaJAPMA8 41,662,1952
intraperitoneal/mouse lethal dose (50 percent kill): 15500 µg/kgNNGADV 17,S155,1992
intraperitoneal/rabbit lowest published lethal dose: 50 mg/kgBehavioral: ComaJAPMA8 41,662,1952
intraperitoneal/rat lethal dose (50 percent kill): 8700 µg/kgNNGADV 17,S155,1992
intravenous/mouse lethal dose (50 percent kill): 18 mg/kgCSLNX* NX#04886
oral/guinea pig lethal dose (50 percent kill): 200 mg/kgFATOAO 32,356,1969
oral/mouse lethal dose (50 percent kill): 480 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
FATOAO 28,230,1965
oral/rabbit lethal dose (50 percent kill): 400 mg/kgPCOC** -,1250,1966
oral/rat lethal dose (50 percent kill): 267 mg/kgEPASR* 8EHQ-1090-1045
oral/wild bird lethal dose (50 percent kill): 100 mg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): >2 gm/kgEPASR* 8EHQ-1090-1045
skin/rat lethal dose (50 percent kill): >6 gm/kgFMCHA2 -,C329,1991
subcutaneous/mouse lethal dose (50 percent kill): 309 mg/kgNNGADV 17,S155,1992
subcutaneous/rat lethal dose (50 percent kill): 69 mg/kgNNGADV 17,S155,1992
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1400 mg/kg30ZDA9 -,213,1971
unreported route/rat lethal dose (50 percent kill): 1230 mg/kgEQSSDX 3,618,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5 mg/m3/4H/17W- intermittentBlood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
GTPZAB 12(4),12,1968
oral/Dog lowest published toxic dose: 9125 mg/kg/1Y- continuousBehavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 118,174,1956
oral/Dog lowest published toxic dose: 28 mg/kg/4W- continuousGastrointestinal: Hypermotility, diarrheaNNGADV 17,S155,1992
oral/Dog lowest published toxic dose: 3640 mg/kg/2Y- continuousGastrointestinal: Hypermotility, diarrhea

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NNGADV 17,S155,1992
oral/mouse lowest published toxic dose: 16800 mg/kg/14D- continuousGastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-238,1983
oral/mouse lowest published toxic dose: 27300 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-238,1983
oral/mouse lowest published toxic dose: 141316 mg/kg/103W- intermittentLiver: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB83-202622
oral/rat lowest published toxic dose: 22750 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-238,1983
oral/rat lowest published toxic dose: 80080 mg/kg/2Y- continuousBehavioral: Food intake (animal)

Endocrine: Changes in spleen weight

Endocrine: Changes in thyroid weight
NNGADV 17,S155,1992
oral/rat lowest published toxic dose: 45 gm/kg/30D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPMA8 41,662,1952
oral/rat lowest published toxic dose: 770 mg/kg/4W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NNGADV 17,S155,1992
oral/rat lowest published toxic dose: 4368 mg/kg/104W- continuousNutritional and Gross Metabolic: Changes in: CaTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 10.9 gm/kg/26W- continuousBlood: Changes in erythrocyte (RBC) countTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 54.6 gm/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 327.6 gm/kg/78W- continuousMusculoskeletal: Other changesTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 436.8 gm/kg/104W- continuousPeripheral Nerve and Sensation: Structural change in nerve or sheathTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 2184 mg/kg/52W- continuousBlood: Changes in erythrocyte (RBC) countTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 109.2 gm/kg/26W- continuousNutritional and Gross Metabolic: Changes in: CaTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 218.4 gm/kg/52W- continuousEndocrine: Changes in thyroid weightTXCYAC 54,45,1989
oral/rat lowest published toxic dose: 436.8 gm/kg/104W- continuousPeripheral Nerve and Sensation: Structural change in nerve or sheath

Musculoskeletal: Other changes
TXCYAC 54,45,1989
oral/rat lowest published toxic dose: 18746 mg/kg/103W- intermittentSkin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB83-202622

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 53,423,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,259,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,259,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 53,423,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 53,423,1991
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,86,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 71,24615,2006
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWFEREAC 73,54954,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,174,1998
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 (total. dust), Sen, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80305; Number of Industries 20; Total Number of Facilities 2044; Number of Occupations 23; Total Number of Employees Exposed 34594; Total Number of Female Employees Exposed 5542
National Occupational Hazard Survey 1974Hazard Code 80305; Number of Industries 5; Total Number of Facilities 267; Number of Occupations 27; Total Number of Employees Exposed 3838

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0493-8821;8EHQ-0892-8916
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8918
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
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