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Zinc sulfate heptahydrate (1:1:7)

RTECS #: ZH5300000

CAS #: 7446-20-0


UPDATE: May 2008 MW: 287.57 MF: O4SZn•7H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. Sulfuric acid, zinc salt (1:1) , heptahydrate
  2. White vitriol (heptahydrate)
  1. Zinc sulfate (1:1) heptahydrate
  2. Zinc vitriol (heptahydrate)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition intraperitoneal
mouse
20 gm/kg ARGEAR 51,605,1981
micronucleus test multiple
non-mammalian species
100 µg/L MUREAV 370,19,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 75 mg/kg N/R AGACBH 16,580,1985
intraperitoneal
rat
lethal dose (50 percent kill): 200 mg/kg N/R BSPBAD 116,47,1977
intravenous
dog
lowest published lethal dose: 66 mg/kg N/R HBAMAK 4,1419,1935
intravenous
rat
lowest published lethal dose: 49 mg/kg N/R HBAMAK 4,1419,1935
intravenous
rabbit
lowest published lethal dose: 44 mg/kg N/R HBAMAK 4,1419,1935
oral
mouse
lethal dose (50 percent kill): 200 mg/kg N/R WDZAEK 5,98,1991
oral
rat
lethal dose (50 percent kill): 1,260 mg/kg Behavioral: Sleep

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
WDZAEK 5,98,1991
oral
rabbit
lowest published lethal dose: 1,914 mg/kg N/R HBAMAK 4,1419,1935
subcutaneous
dog
lowest published lethal dose: 78 mg/kg N/R HBAMAK 4,1419,1935
subcutaneous
guinea pig
lowest published lethal dose: 590 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Gastrointestinal: Hypermotility, diarrhea
BMJOAE 2,217,1913
subcutaneous
rat
lowest published lethal dose: 330 mg/kg N/R HBAMAK 4,1419,1935
unreported route
man
lowest published lethal dose: 221 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rabbit
lowest published toxic dose: 99 mg/kg/3 week- intermittent Eye: Other eye effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
KOAOAE 93,1,1991
oral
mouse
lowest published toxic dose: 443,898 mg/kg/13 week- continuous Gastrointestinal: Changes in structure or function of exocrine pancreas

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in thymus weight
NNGADV 6,327,1981
oral
mouse
lowest published toxic dose: 350 mg/kg/14 day- continuous Skin and Appendages: Other: Hair EXPDE* 14,844,2005
oral
mouse
lowest published toxic dose: 1,460 mg/kg/1 year- intermittent Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BJDEAZ 155,39,2006
oral
rat
lowest published toxic dose: 226,226 mg/kg/13 week- continuous Gastrointestinal: Changes in structure or function of exocrine pancreas

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NNGADV 6,327,1981
oral
rat
lowest published toxic dose: 4,726.4 mg/kg/16 week- continuous Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 171,10,2007
oral
rat
lowest published toxic dose: 1,271.2 mg/kg/8 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOLED5 169,26,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7277;
Number of Industries 2;
Total Number of Facilities 160;
Number of Occupations 5;
Total Number of Employees Exposed 2,849;
Total Number of Female Employees Exposed 705


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
BSPBAD Bulletin de la Societe de Pharmacie de Bordeaux. (Societe de Pharmacie de Bordeaux, Faculte de Pharmacie, 91, rue Leyteire, 33076 Bordeaux, France) V.89- 1951-
EXPDE* Experimental dermatology (Copenhagen : Munksgaard) V.1- 1992-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
KOAOAE Klinika Oczna. Eye Clinic. (Ars Polona, POB 100, 100-068 Warsaw, Poland) V.1- 1923-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

NIOSH PROFILE (ZINC AND ITS COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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