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Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc sulfate heptahydrate (1:1:7)

RTECS #

ZH5300000

CAS #

7446-20-0

Updated

July 2013

Molecular Weight

287.57

Molecular Formula

O4SZn·7H2O

Synonyms

Sulfuric acid, zinc salt (1:1), heptahydrate
White vitriol (heptahydrate)
Zinc sulfate (1:1) heptahydrate
Zinc vitriol (heptahydrate)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionintraperitoneal/mouse20 gm/kgARGEAR 51,605,1981
micronucleus testmultiple/non-mammalian species100 µg/LMUREAV 370,19,1996

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 75 mg/kgAGACBH 16,580,1985
intraperitoneal/rat lethal dose (50 percent kill): 200 mg/kgBSPBAD 116,47,1977
intratracheal/rat lowest published toxic dose: 287.6 µg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TXAPA9 241,71,2009
intravenous/Dog lowest published lethal dose: 66 mg/kgHBAMAK 4,1419,1935
intravenous/rabbit lowest published lethal dose: 44 mg/kgHBAMAK 4,1419,1935
intravenous/rat lowest published lethal dose: 49 mg/kgHBAMAK 4,1419,1935
oral/mouse lethal dose (50 percent kill): 200 mg/kgWDZAEK 5,98,1991
oral/rabbit lowest published lethal dose: 1914 mg/kgHBAMAK 4,1419,1935
oral/rat lethal dose (50 percent kill): 1260 mg/kgBehavioral: Sleep

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
WDZAEK 5,98,1991
subcutaneous/Dog lowest published lethal dose: 78 mg/kgHBAMAK 4,1419,1935
subcutaneous/guinea pig lowest published lethal dose: 590 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Gastrointestinal: Hypermotility, diarrhea
BMJOAE 2,217,1913
subcutaneous/rat lowest published lethal dose: 330 mg/kgHBAMAK 4,1419,1935
unreported route/man lowest published lethal dose: 221 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intravenous/rabbit lowest published toxic dose: 99 mg/kg/3W- intermittentEye: Other eye effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
KOAOAE 93,1,1991
oral/mouse lowest published toxic dose: 350 mg/kg/14D- continuousSkin and Appendages: Other: HairEXPDE* 14,844,2005
oral/mouse lowest published toxic dose: 1460 mg/kg/1Y- intermittentSkin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BJDEAZ 155,39,2006
oral/mouse lowest published toxic dose: 443898 mg/kg/13W- continuousGastrointestinal: Changes in structure or function of exocrine pancreas

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in thymus weight
NNGADV 6,327,1981
oral/rat lowest published toxic dose: 226226 mg/kg/13W- continuousGastrointestinal: Changes in structure or function of exocrine pancreas

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NNGADV 6,327,1981
oral/rat lowest published toxic dose: 4726.4 mg/kg/16W- continuousGastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 171,10,2007
oral/rat lowest published toxic dose: 1271.2 mg/kg/8W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOLED5 169,26,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, resp, 2011
Occupational Exposure Limit-GERMANYMAK 2 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Zn)/m3, KZG-week 0.4 mg(Zn)/m3, resp, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg(Zn)/m3, KZG-week 4 mg(Zn)/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7277; Number of Industries 2; Total Number of Facilities 160; Number of Occupations 5; Total Number of Employees Exposed 2849; Total Number of Female Employees Exposed 705
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