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Zinc sulfate (1:1)

RTECS #: ZH5260000

CAS #: 7733-02-0


UPDATE: May 2009 MW: 161.43 MF: O4SZn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Bonazen
  2. Bufopto zinc sulfate
  3. Complexonat
  4. OP - Thal - zin
  5. Optraex
  6. Sulfate de zinc (French)
  7. Sulfuric acid, zinc salt (1:1)
  1. Verazinc
  2. White copperas
  3. White vitriol
  4. Zinc sulphate
  5. Zinc vitriol
  6. Zincomed
  7. Zinkosite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
420 g moderate JAPMA8 45,474,1956


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis rat Ascites tumor 1 gm/kg GANNA2 54,155,1963
DNA inhibition human HeLa cell 1 mol/L/4 hour BECTA6 32,220,1984
mutation in microorganisms Saccharomyes cerevisiae 100 mmol/L (-enzymatic activation step) MUREAV 117,149,1983
micronucleus test intraperitoneal
mouse
1,800 g/kg GWZHEW 12,77,1986
gene conversion and mitotic recombination Saccharomyes cerevisiae 100 mmol/L MUREAV 117,149,1983
morphological transform hamster embryo 200 mol/L CNREA8 39,193,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravaginal
rabbit
lowest published toxic dose: 34,573 g/kg (1 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) CCPTAY 22,659,1980
intravenous
hamster
lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ENVRAL 6,95,1973
oral
domestic animal
lowest published toxic dose: 193 gm/kg (6-20 week pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
ENVRAL 20,1,1979
oral
rat
lowest published toxic dose: 333 mg/kg (1-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NURIBL 13,33,1976
subcutaneous
hamster
lowest published toxic dose: 15 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
ENVRAL 35,405,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rabbit
lowest published toxic dose: 3,625 g/kg/5 day- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
COREAF 236,1387,1953


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraduodenal
dog
lowest published toxic dose: 161 mg/kg/1 hour Gastrointestinal: Alteration in gastric secretion AJPHAP 248,G28,1985
intraperitoneal
mouse
lethal dose (50 percent kill): 29,060 g/kg N/R COREAF 256,1043,1963
intraperitoneal
rat
lethal dose (50 percent kill): 196 mg/kg N/R INJPD2 23,153,1991
intraperitoneal
rat
lowest published toxic dose: 32.3 gm/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 213.74.2005
intratracheal
rat
lowest published toxic dose: 33 g/kg Lung, Thorax, or Respiration: Sputum

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 70,73,2002
intratracheal
rat
lowest published toxic dose: 161 g/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
TOXID9 78,17,2004
intratracheal
rat
lowest published toxic dose: 161 g/kg Cardiac: Cardiomyopathy including infarction TOXID9 78,17,2004
intratracheal
rat
lowest published toxic dose: 131 g/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 211,41,2006
intratracheal
rat
lowest published toxic dose: 322.86 g/kg Cardiac: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTEHF8 69,2011,2006
intravenous
dog
lowest published lethal dose: 66 mg/kg N/R EQSSDX 1,1,1975
intravenous
dog
lowest published toxic dose: 4.8 mg/kg/15 minute Gastrointestinal: Alteration in gastric secretion AJPHAP 248,G28,1985
intravenous
mouse
lethal dose (50 percent kill): 23,300 g/kg N/R INJPD2 23,153,1991
intravenous
rat
lethal dose (50 percent kill): 69,900 g/kg N/R INJPD2 23,153,1991
intravenous
rabbit
lowest published lethal dose: 23 mg/kg N/R TXAPA9 9,269,1966
oral
human
lowest published toxic dose: 45 mg/kg/7 day- continuous Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Other changes

Blood: Normocytic anemia
BMJOAE 1,754,1978
oral
human
lowest published toxic dose: 106 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Hypermotility, diarrhea
BMJOAE 1,1390,1977
oral
human
lowest published toxic dose: 14.29 mg/kg Gastrointestinal: Nausea or vomiting HBPTO* 2,1366,2001
oral
man
lowest published toxic dose: 180 mg/kg/6 week- intermittent Blood: Other changes JAMAAP 252,1443,1984
oral
mouse
lethal dose (50 percent kill): 245 mg/kg N/R YHTPAD 22,230,1987
oral
rabbit
lethal dose (50 percent kill): 2 gm/kg N/R IPSTB3 3,93,1976
oral
woman
lowest published toxic dose: 3,120 mg/kg/43 week- intermittent Blood: Microcytosis with or without anemia

Blood: Angranulocytosis

Nutritional and Gross Metabolic: Changes in: Other metals
GASTAB 94,508,1988
subcutaneous
dog
lowest published lethal dose: 78 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
mouse
lethal dose (50 percent kill): 781 mg/kg Gastrointestinal: Changes in pancreatic weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
JJTHEC 44,305,1998
subcutaneous
rat
lowest published lethal dose: 330 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
rabbit
lowest published lethal dose: 300 mg/kg N/R EQSSDX 1,1,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 84 mg/kg/4 week- intermittent Endocrine: Evidence of thyroid hyperfunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 195,69,2004
intratracheal
rat
lowest published toxic dose: 267.2 g/kg/8 week- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,89,2005
intratracheal
rat
lowest published toxic dose: 267.2 g/kg/16 week- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,89,2005
oral
domestic animal
lowest published toxic dose: 7,110 mg/kg/4 week- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JJATDK 4,92,1984
oral
human
lowest published toxic dose: 560 mg/kg/8 week- intermittent Gastrointestinal: Nausea or vomiting BJDEAZ 146,423,2002
oral
mouse
lowest published toxic dose: 44,424 mg/kg/18 day- continuous Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXCYAC 132,33,1999
oral
mouse
lowest published toxic dose: 36 mg/kg/10 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Other changes

Biochemical: Metabolism (intermediary): Other proteins
CEXPB9 32,273,2005
oral
rat
lowest published toxic dose: 74 mg/kg/3 day- intermittent Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
TXAPA9 67,224,1983
oral
rat
lowest published toxic dose: 1,200 mg/kg/60 day- continuous Liver: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
CHHTAT 72,391,1992
oral
rat
lowest published toxic dose: 476.7 mg/kg/3 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
CEXPB9 27,694,2000
oral
rat
lowest published toxic dose: 2,889 mg/kg/8 week- continuous Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
DCTODJ 1,11,2006
subcutaneous
mouse
lowest published toxic dose: 40 mg/kg/2 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXAPA9 204,9,2005
subcutaneous
mouse
lowest published toxic dose: 96,858 g/kg/2 day- intermittent Cardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 170,66,2007
subcutaneous
rat
lowest published toxic dose: 200 mg/kg/10 day- intermittent Liver: Other changes TOLED5 158,108,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
ENTOX* -,479,2005
TOXICOLOGY REVIEW
HBTME* ,925,2007
TOXICOLOGY REVIEW
HUTOX* -,515,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 77220;
Number of Industries 52;
Total Number of Facilities 3,067;
Number of Occupations 47;
Total Number of Employees Exposed 40,653
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 77220;
Number of Industries 52;
Total Number of Facilities 4,755;
Number of Occupations 66;
Total Number of Employees Exposed 89,451;
Total Number of Female Employees Exposed 27,887


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in chemical and pharmaceutical manufacture
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915- Suspended 1967-72.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GASTAB Gastroenterology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1943-
GWZHEW Gongye Weisheng Yu Zhiyebing. Industrial Health and Occupational Diseases. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1973-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HBTME*
HUTOX*
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NURIBL Nutrition Reports International. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU.

Used in chemical and pharmaceutical manufacture

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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