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Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc sulfate (1:1)

RTECS #

ZH5260000

CAS #

7733-02-0

Updated

July 2013

Molecular Weight

161.43

Molecular Formula

O4S·Zn

Synonyms

Bonazen
Bufopto zinc sulfate
Complexonat
OP-Thal-zin
Optraex
Sulfate de zinc (French)
Sulfuric acid, zinc salt (1:1)
Verazinc
White copperas
White vitriol
Zinc sulphate
Zinc vitriol
Zincomed
Zinkosite

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 420 µg moderateJAPMA8 45,474,1956

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic AnalysisAscites tumor/rat1 gm/kgGANNA2 54,155,1963
DNA inhibitionHeLa cell/human1 µmol/L/4HBECTA6 32,220,1984
gene conversion and mitotic recombination/Saccharomyes cerevisiae100 mmol/LMUREAV 117,149,1983
micronucleus testintraperitoneal/mouse1800 µg/kgGWZHEW 12,77,1986
morphological transformembryo/hamster200 µmol/LCNREA8 39,193,1979
mutation in microorganisms/Saccharomyes cerevisiae100 mmol/L (-enzymatic activation step)MUREAV 117,149,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intravaginal/rabbit 34573 µg/kg (1D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)CCPTAY 22,659,1980
intravenous/hamster 2 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ENVRAL 6,95,1973
oral/domestic animal 193 gm/kg (6-20W pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
ENVRAL 20,1,1979
oral/rat 333 mg/kg (1-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NURIBL 13,33,1976
subcutaneous/hamster 15 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
ENVRAL 35,405,1984

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rabbit lowest published toxic dose: 3625 µg/kg/5D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
COREAF 236,1387,1953

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraduodenal/Dog lowest published toxic dose: 161 mg/kg/1HGastrointestinal: Alteration in gastric secretionAJPHAP 248,G28,1985
intraperitoneal/mouse lethal dose (50 percent kill): 29060 µg/kgCOREAF 256,1043,1963
intraperitoneal/rat lethal dose (50 percent kill): 196 mg/kgINJPD2 23,153,1991
intraperitoneal/rat lowest published toxic dose: 32.3 gm/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 213.74.2005
intraperitoneal/rat lowest published toxic dose: 15 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 -,239,2009
intratracheal/rat lowest published toxic dose: 322.86 µg/kgCardiac: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTEHF8 69,2011,2006
intratracheal/rat lowest published toxic dose: 33 µg/kgLung, Thorax, or Respiration: Sputum

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 70,73,2002
intratracheal/rat lowest published toxic dose: 161 µg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes
TOXID9 78,17,2004
intratracheal/rat lowest published toxic dose: 161 µg/kgCardiac: Cardiomyopathy including infarctionTOXID9 78,17,2004
intratracheal/rat lowest published toxic dose: 131 µg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 211,41,2006
intravenous/Dog lowest published toxic dose: 4.8 mg/kg/15MGastrointestinal: Alteration in gastric secretionAJPHAP 248,G28,1985
intravenous/Dog lowest published lethal dose: 66 mg/kgEQSSDX 1,1,1975
intravenous/mouse lethal dose (50 percent kill): 23300 µg/kgINJPD2 23,153,1991
intravenous/rabbit lowest published lethal dose: 23 mg/kgTXAPA9 9,269,1966
intravenous/rat lethal dose (50 percent kill): 69900 µg/kgINJPD2 23,153,1991
oral/human lowest published toxic dose: 45 mg/kg/7D- continuousCardiac: Pulse rate increased without fall in BP

Gastrointestinal: Other changes

Blood: Normocytic anemia
BMJOAE 1,754,1978
oral/human lowest published toxic dose: 106 mg/kgVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Hypermotility, diarrhea
BMJOAE 1,1390,1977
oral/human lowest published toxic dose: 14.29 mg/kgGastrointestinal: Nausea or vomitingHBPTO* 2,1366,2001
oral/man lowest published toxic dose: 180 mg/kg/6W- intermittentBlood: Other changesJAMAAP 252,1443,1984
oral/mouse lethal dose (50 percent kill): 245 mg/kgYHTPAD 22,230,1987
oral/rabbit lethal dose (50 percent kill): 2 gm/kgIPSTB3 3,93,1976
oral/woman lowest published toxic dose: 3120 mg/kg/43W- intermittentBlood: Microcytosis with or without anemia

Blood: Angranulocytosis

Nutritional and Gross Metabolic: Changes in: Other metals
GASTAB 94,508,1988
subcutaneous/Dog lowest published lethal dose: 78 mg/kgEQSSDX 1,1,1975
subcutaneous/mouse lethal dose (50 percent kill): 781 mg/kgGastrointestinal: Changes in pancreatic weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
JJTHEC 44,305,1998
subcutaneous/rabbit lowest published lethal dose: 300 mg/kgEQSSDX 1,1,1975
subcutaneous/rat lowest published lethal dose: 330 mg/kgEQSSDX 1,1,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 µg/m3/16W- intermittentCardiac: Cardiomyopathy including infarction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TXAPA9 232,69,2008
intraperitoneal/rat lowest published toxic dose: 84 mg/kg/4W- intermittentEndocrine: Evidence of thyroid hyperfunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 195,69,2004
intratracheal/rat lowest published toxic dose: 267.2 µg/kg/8W- intermittentCardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,89,2005
intratracheal/rat lowest published toxic dose: 267.2 µg/kg/16W- intermittentCardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,89,2005
oral/domestic animal lowest published toxic dose: 7110 mg/kg/4W- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JJATDK 4,92,1984
oral/human lowest published toxic dose: 560 mg/kg/8W- intermittentGastrointestinal: Nausea or vomitingBJDEAZ 146,423,2002
oral/mouse lowest published toxic dose: 36 mg/kg/10D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Other changes

Biochemical: Metabolism (intermediary): Other proteins
CEXPB9 32,273,2005
oral/mouse lowest published toxic dose: 44424 mg/kg/18D- continuousGastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXCYAC 132,33,1999
oral/rat lowest published toxic dose: 2889 mg/kg/8W- continuousLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
DCTODJ 1,11,2006
oral/rat lowest published toxic dose: 476.7 mg/kg/3W- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
CEXPB9 27,694,2000
oral/rat lowest published toxic dose: 74 mg/kg/3D- intermittentMusculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
TXAPA9 67,224,1983
oral/rat lowest published toxic dose: 1200 mg/kg/60D- continuousLiver: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
CHHTAT 72,391,1992
subcutaneous/mouse lowest published toxic dose: 40 mg/kg/2D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXAPA9 204,9,2005
subcutaneous/mouse lowest published toxic dose: 96858 µg/kg/2D- intermittentCardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 170,66,2007
subcutaneous/rat lowest published toxic dose: 200 mg/kg/10D- intermittentLiver: Other changesTOLED5 158,108,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWENTOX* -,479,2005
TOXICOLOGY REVIEWHBTME* ,925,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, resp, 2011
Occupational Exposure Limit-GERMANYMAK 2 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Cu)/m3, KZG-week 0.2 mg(Cu)/m3, inhal, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Zn)/m3, KZG-week 0.4 mg(Zn)/m3, resp, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg(Zn)/m3, KZG-week 4 mg(Zn)/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 77220; Number of Industries 52; Total Number of Facilities 4755; Number of Occupations 66; Total Number of Employees Exposed 89451; Total Number of Female Employees Exposed 27887
National Occupational Hazard Survey 1974Hazard Code 77220; Number of Industries 52; Total Number of Facilities 3067; Number of Occupations 47; Total Number of Employees Exposed 40653

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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