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Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc, (ethylenebis(dithiocarbamato))-

RTECS #

ZH3325000

CAS #

12122-67-7; 142-14-3; 14039-25-9

Updated

April 2013

Molecular Weight

275.73

Molecular Formula

C4H6N2S4·Zn

Synonyms

((1,2-Ethanediylbis(carbamodithioato))(2-))zinc
1,2-Ethanediylbis(carbamodithioato) (2-)-S,S'-zinc
1,2-Ethanediylbiscarbamodithioic acid, zinc complex
Aaphytora
Aspor
Asporum
Bercema
Blightox
Blizene
Carbadine
CHEM zineb
Cineb
Crittox
Cynkotox
Daisen
Devizeb
Dipher
Discon-Z
Dithane 65
Dithane Z
Dithane Z-78
Ditiamina
ENT 14,874
Ethylenebis(dithiocarbamato)zinc
Ethylenebis(dithiocarbamic acid), zinc salt
Hexathane
Kupratsin
Kypzin
Lirotan
Lonacol
Micide
Novosir N
Novozin N 50
Novozir
Novozir N
Novozir N 50
Pamosol 2 forte
Parzate C
Parzate zineb
Perosin
Perosin 75B
Perozin
Perozine
Phytox
Polyram Z
Sperlox-Z
Tanazon
Thiodow
Tiazin
Tiezene
Tritoftorol
Tsineb (Russian)
Zebenide
Zebtox
Zidan
Zinc ethylene-1,2-bisdithiocarbamate
Zinc ethylenebisdithiocarbamate
Zineb
Zineb 75
Zineb 75 WP
Zineb 80
Zink-(N,N'-aethylen-bis(dithiocarbamat)) (German)
Zinosan

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/human500 µg/m3/7H/3Y- intermittentGTPZAB 20(12),26,1976
Cytogenetic Analysisoral/mouse10 mg/kgGISAAA 45(1),80,1980
Cytogenetic Analysisother cell types/human0.1 mg/L/48HMUTAEX 16,487,2001
Cytogenetic AnalysisHeLa cell/human5 mg/L/24HMUREAV 536,121,2003
Cytogenetic Analysisfibroblast/human1 mg/L/24HMUREAV 536,121,2003
Cytogenetic Analysisother cell types/human1 mg/L/24HMUREAV 536,121,2003
Cytogenetic Analysisovary/hamster1 mg/L/24HMUREAV 536,121,2003
DNA Damageintraperitoneal/rat50 mg/kgMUREAV 302,1,1993
DNA Damageovary/hamster1 mg/L/80MMUREAV 514,201,2002
DNA Damageleukocyte/rat125 µg/L/1HTXAPA9 211,87,2006
DNA inhibitionother cell types/rat1 mg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human10 mg/LARTODN 45,101,1980
gene conversion and mitotic recombination/Saccharomyes cerevisiae60 ppmNTIS** PB85-193761
micronucleus testlymphocyte/human25 mg/L/72HEMMUEG 40,57,2002
mutation in microorganisms/Bacillus subtilis1 nmol/plate (-enzymatic activation step)MSERDS 5,93,1981
mutation in microorganisms/Other microorganisms1000 ppm (-enzymatic activation step)MMAPAP 50,233,1973
other mutation test systemsfibroblast/human10 µg/kgGTPZAB 17(3),32,1973
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster50 ppm/4D-continuousMUREAV 206,25,1988
sister chromatid exchangelymphocyte/human10 mg/LGESKAC 12,118,1979
sister chromatid exchangeovary/hamster1 mg/L/24HMUTAEX 18,505,2003
sister chromatid exchangeother cell types/human50 mg/L/72HMUTAEX 16,487,2001
sister chromatid exchangeovary/hamster10 mg/L/36HMUREAV 514,201,2002
specific locus testoral/Drosophila melanogaster50 ppm/4D-continuousMUREAV 206,25,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 20 mg/m3/4H (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)GISAAA 37(8),42,1972
oral/rat 28 gm/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB80-181175
oral/rat 4 gm/kg (13D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FCTXAV 11,239,1973
oral/rat 4 gm/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death
FCTXAV 11,239,1973
oral/rat 8 gm/kg (9D pregnant)Reproductive: Effects on fertility: Other measures of fertilityEKMMA8 10,226,1971
oral/rat 4 gm/kg (13D pregnant)Reproductive: Specific developmental abnormalities: Eye, earEKMMA8 10,226,1971
oral/rat 8 mg/kg (16D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTOERD9 3,279,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 80 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
VPITAR 29,71,1970
intraperitoneal/mouse lowest published toxic dose: 2600 mg/kg/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VRDEA5 (9),100,1966
intraperitoneal/mouse lowest published toxic dose: 1760 mg/kg (11-21D pregnant)Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
VPITAR 30,49,1971
oral/mouse lowest published toxic dose: 7800 mg/kg/5W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GISAAA 37(9),25,1972
oral/rat lowest published toxic dose: 273 gm/kg/2.5Y- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors
JTSCDR 4,290,1979
oral/rat lowest published toxic dose: 53580 mg/kg/94W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Gastrointestinal: Colon tumors
VPITAR 29,71,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 800 mg/m3/4H85GMAT -,121,1982
intraperitoneal/mouse lethal dose (50 percent kill): 1940 mg/kg85GMAT -,121,1982
intraperitoneal/rat lowest published toxic dose: 70 mg/kgEndocrine: Other changesATSUDG 8,253,1985
oral/human lowest published lethal dose: 5 gm/kg85JFAN A420,1984
oral/mouse lethal dose (50 percent kill): 7600 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia
JTEHD6 4,93,1978
oral/rabbit lethal dose (50 percent kill): 4450 mg/kg85GMAT -,121,1982
oral/rat lethal dose (50 percent kill): 1850 mg/kgBehavioral: Excitement

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 31(10),25,1966
skin/rat lethal dose (50 percent kill): >2500 mg/kgTXAPA9 14,515,1969
Tank with water/Daphnia lethal concentration (50 percent kill): 0.97 mg/L/48HAQUTO* 7,145,1985
Tank with water/Daphnia lethal concentration (50 percent kill): 89 µg/L/21DAQUTO* 7,165,1985
Tank with water/Daphnia Lowest published lethal concentration: 32 µg/L/21DAQUTO* 7,165,1985
Tank with water/Guppy lethal concentration (50 percent kill): 7.2 mg/L/96HAQUTO* 7,145,1985
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1350 mg/kgGISAAA 45(5),29,1980
unreported route/rat lethal dose (50 percent kill): 1850 mg/kgEQSSDX 3,618,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 700 mg/kg/14D- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumNRTXDN 28,727,2007
oral/cattle lowest published toxic dose: 10800 mg/kg/39W- intermittentEndocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Changes in testicular weight
ATSUDG 12,107,1988
oral/rabbit lowest published toxic dose: 18200 mg/kg/26W- intermittentGastrointestinal: Alteration in gastric secretion

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 31(10),25,1966
oral/rabbit lowest published toxic dose: 6231 mg/kg/90D- continuousLiver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight
VHTODE 37,137,1995
oral/rat lowest published toxic dose: 14 gm/kg/2W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** PB80-181175
oral/rat lowest published toxic dose: 30 gm/kg/30D- intermittentEndocrine: Other changes

Endocrine: Changes in pituitary weight

Endocrine: Changes in thyroid weight
BECTA6 22,208,1979
oral/rat lowest published toxic dose: 364 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Other changes

Endocrine: Thyroid weight (goiter)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 109,159,1953
oral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentEndocrine: HypoglycemiaBECTA6 56,847,1996

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,245,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,245,1976
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWCNDQA8 14,49,1979
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,86,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,561,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,218,1998
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83787; Number of Industries 1; Total Number of Facilities 291; Number of Occupations 1; Total Number of Employees Exposed 3205
National Occupational Hazard Survey 1974Hazard Code 83787; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #107
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