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Zinc

RTECS #: ZG8600000

CAS #: 7440-66-6


UPDATE: May 2009 MW: 65.37 MF: Zn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Blue powder
  2. Granular zinc
  3. LS 2
  4. LS 6
  1. Merrillite
  2. Rheinzink
  3. Zinc dust
  4. Zinc powder


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
human
300 g/3 day- intermittent mild 85DKA8 -,127,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 12.600 mg/kg/46 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 143,63,1999


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 124 mg/m3/50 minute Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Sweating
AHYGAJ 72,358,1910
intratracheal
rat
lowest published toxic dose: 25 mg/kg Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
VCVN1* -,151,1988
multiple
non-mammalian species
lethal concentration (50 percent kill): 23 gm/m3/24 hour N/R TXAPA9 197,177,2004
oral
duck
lowest published lethal dose: 388 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia

Blood: Changes in leukocyte (WBC) count
JWIDAW 36,111,2000
oral
mouse
lowest published lethal dose: 5 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Liver: Hepatitis (hepatocellular necrosis), zonal
TOLED5 161,115,2006
oral
mouse
lowest published toxic dose: 5 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 161,115,2006
oral
mouse
lowest published lethal dose: 5,000 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
TOLED5 161,115,2006
oral
mouse
lowest published toxic dose: 5,000 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 161,115,2006


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
woman
lowest published toxic concentration: 2.4 mg/m3/5 year- intermittent Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN1* -,154,1988
oral
woman
lowest published toxic dose: 70 mg/kg/10 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,143,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
QURBAW 7,75,1974
TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
AMTODM 3,209,1977
TOXICOLOGY REVIEW
CREOH* 42,93,2002
TOXICOLOGY REVIEW
MAERE* 51,247,2001
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
TPHSDY 23,426,2002
TOXICOLOGY REVIEW
CBCPAI 132,269,2002
TOXICOLOGY REVIEW
ENTOX* -,479,2005
TOXICOLOGY REVIEW
REPTED 23,260,2007
TOXICOLOGY REVIEW
REPTED 23,428,2007
TOXICOLOGY REVIEW
HBTME* ,925,2007
TOXICOLOGY REVIEW
HUTOX* -,515,1996
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,346,1998
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0146;
Number of Industries 2;
Total Number of Facilities 44;
Number of Occupations 1;
Total Number of Employees Exposed 324
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 77115;
Number of Industries 120;
Total Number of Facilities 9,450;
Number of Occupations 90;
Total Number of Employees Exposed 118,548
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4242;
Number of Industries 46;
Total Number of Facilities 3,278;
Number of Occupations 47;
Total Number of Employees Exposed 79,920;
Total Number of Female Employees Exposed 7,874
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5913;
Number of Industries 1;
Total Number of Facilities 22;
Number of Occupations 2;
Total Number of Employees Exposed 269;
Total Number of Female Employees Exposed 22
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5990;
Number of Industries 2;
Total Number of Facilities 42;
Number of Occupations 3;
Total Number of Employees Exposed 1,007;
Total Number of Female Employees Exposed 321
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5991;
Number of Industries 8;
Total Number of Facilities 177;
Number of Occupations 18;
Total Number of Employees Exposed 10,589;
Total Number of Female Employees Exposed 3,273
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 77115;
Number of Industries 211;
Total Number of Facilities 23,711;
Number of Occupations 133;
Total Number of Employees Exposed 320,917;
Total Number of Female Employees Exposed 34,194


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100236/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human lymphocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in copper alloys, galvanizing, light alloys, rolled and wire drawn zinc, sheet products
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Zinc and compounds as Zn, 7030
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
OSHA ANALYTICAL METHOD #ID121
OSHA ANALYTICAL METHOD #ID125G


REFERENCES:

CODEN
REFERENCE

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AHYGAJ Archiv fuer Hygiene. (Munich, Fed. Rep. Ger.) V.1-100, 1883-1928. For publisher information, see ZHPMAT.
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8.
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
HBTME*
HTOPA*
HUTOX*
JWIDAW Journal of Wildlife Diseases. (Wildlife Disease Assoc., POB 886, Ames, IA 50010) V.6- 1970-
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
MAERE* Marine Environmental Research. (Kidlington, Oxford : Elsevier) V. 1- 1978-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
QURBAW Quarterly Reviews of Biophysics. (Cambridge Univ. Press, The Edinburgh Bldg., Shaftesbury Rd., Cambridge CB2 2RU, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in copper alloys, galvanizing, light alloys, rolled and wire drawn zinc, sheet products

NIOSH PROFILE (HEAVY METAL GREASES AND SOAPS), SRI, 2/77

NIOSH PROFILE (PRINTING INDUSTRY), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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