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Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc

RTECS #

ZG8600000

CAS #

7440-66-6

Updated

September 201

Molecular Weight

65.37

Molecular Formula

Zn

Synonyms

Blue powder
Granular zinc
LS 2
LS 6
Merrillite
Rheinzink
Zinc dust
Zinc powder

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 300 µg/3D- intermittent mild85DKA8 -,127,1977

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 12.600 mg/kg/46W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 143,63,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 124 mg/m3/50MLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Sweating
AHYGAJ 72,358,1910
intratracheal/rat lowest published toxic dose: 25 mg/kgLung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
VCVN1* -,151,1988
multiple/non-mammalian species lethal concentration (50 percent kill): 23 gm/m3/24HTXAPA9 197,177,2004
oral/duck lowest published lethal dose: 388 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia

Blood: Changes in leukocyte (WBC) count
JWIDAW 36,111,2000
oral/mouse lowest published lethal dose: 5 gm/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Liver: Hepatitis (hepatocellular necrosis), zonal
TOLED5 161,115,2006
oral/mouse lowest published toxic dose: 5 gm/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 161,115,2006
oral/mouse lowest published lethal dose: 5000 mg/kgGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
TOLED5 161,115,2006
oral/mouse lowest published toxic dose: 5000 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 161,115,2006
Tank with water/Daphnia lethal concentration (50 percent kill): 160 µg/L/48HTIVIEQ 31,125,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/woman lowest published toxic concentration: 2.4 mg/m3/5Y- intermittentBlood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN1* -,154,1988
oral/rat lowest published toxic dose: 17920 mg/kg/20W- continuousBlood: Microcytosis with or without anemia

Blood: Changes in spleen

Nutritional and Gross Metabolic: Changes in: Fe
TOLED5 191,15,2009
oral/woman lowest published toxic dose: 70 mg/kg/10W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,143,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWQURBAW 7,75,1974
TOXICOLOGY REVIEWADTEAS 5,51,1972
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWKOTTAM 11,1300,1975
TOXICOLOGY REVIEWAMTODM 3,209,1977
TOXICOLOGY REVIEWCREOH* 42,93,2002
TOXICOLOGY REVIEWMAERE* 51,247,2001
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWTPHSDY 23,426,2002
TOXICOLOGY REVIEWCBCPAI 132,269,2002
TOXICOLOGY REVIEWENTOX* -,479,2005
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWREPTED 23,428,2007
TOXICOLOGY REVIEWHBTME* ,925,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWMUREAV 674,73,2009
TOXICOLOGY REVIEWMUREAV 667,82,2009
TOXICOLOGY REVIEWNEUCL* 23,485,2005
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWNTAPM* -,689,1995
TOXICOLOGY REVIEWMUTAEX 27,257,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,346,1998
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit-GERMANYMAK 0.1 mg/m3, resp, 2011
Occupational Exposure Limit-GERMANYMAK 2 mg/m3, inhal, 2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, KZG-week 0.4 mg/m3, resp, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg/m3, KZG-week 4 mg/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4242; Number of Industries 46; Total Number of Facilities 3278; Number of Occupations 47; Total Number of Employees Exposed 79920; Total Number of Female Employees Exposed 7874
National Occupational Exposure Survey 1983Hazard Code X5913; Number of Industries 1; Total Number of Facilities 22; Number of Occupations 2; Total Number of Employees Exposed 269; Total Number of Female Employees Exposed 22
National Occupational Exposure Survey 1983Hazard Code X5990; Number of Industries 2; Total Number of Facilities 42; Number of Occupations 3; Total Number of Employees Exposed 1007; Total Number of Female Employees Exposed 321
National Occupational Exposure Survey 1983Hazard Code X5991; Number of Industries 8; Total Number of Facilities 177; Number of Occupations 18; Total Number of Employees Exposed 10589; Total Number of Female Employees Exposed 3273
National Occupational Exposure Survey 1983Hazard Code 77115; Number of Industries 211; Total Number of Facilities 23711; Number of Occupations 133; Total Number of Employees Exposed 320917; Total Number of Female Employees Exposed 34194
National Occupational Hazard Survey 1974Hazard Code T0146; Number of Industries 2; Total Number of Facilities 44; Number of Occupations 1; Total Number of Employees Exposed 324
National Occupational Hazard Survey 1974Hazard Code 77115; Number of Industries 120; Total Number of Facilities 9450; Number of Occupations 90; Total Number of Employees Exposed 118548

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100236/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human lymphocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
NIOSH Analytical Method, 1994: Zinc and compounds as Zn, 7030
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID121
OSHA ANALYTICAL METHOD #ID125G
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