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Registry of Toxic Effects of Chemical Substances (RTECS)

3,4-Xylidine

RTECS #

ZE9450000

CAS #

95-64-7

Updated

July 2013

Molecular Weight

121.20

Molecular Formula

C8H11N

Synonyms

3,4-Dimethylaminobenzene
3,4-Dimethylaniline
3,4-Dimethylbenzenamine
3,4-Dimethylphenylamine
3,4-Xylylamine
Aniline, 3,4-dimethyl
Benzenamine, 3,4-dimethyl- (9CI)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionintraperitoneal/mouse100 mg/kgMUREAV 46,305,1977
mutation in microorganisms/Salmonella typhimurium5 µmol/plate (-enzymatic activation step)MUREAV 77,317,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 707 mg/kgNTIS** PB214-270
oral/rat lethal dose (50 percent kill): 812 mg/kgAMRL** TR-72-62,1972
oral/wild bird lethal dose (50 percent kill): 5600 µg/kgTXAPA9 21,315,1972

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 626,135,2007
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (25 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (10 mg/m3), skin, JAN2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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