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3,4 - Xylidine

RTECS #: ZE9450000

CAS #: 95-64-7


UPDATE: February 2009 MW: 121.20 MF: C8H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 3,4 - Dimethylaminobenzene
  2. 3,4 - Dimethylaniline
  3. 3,4 - Dimethylbenzenamine
  4. 3,4 - Dimethylphenylamine
  1. 3,4 - Xylylamine
  2. Aniline, 3,4 - dimethyl
  3. Benzenamine, 3,4 - dimethyl - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition intraperitoneal
mouse
100 mg/kg MUREAV 46,305,1977
mutation in microorganisms Salmonella typhimurium 5 µmol/plate (-enzymatic activation step) MUREAV 77,317,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
wild bird
lethal dose (50 percent kill): 5,600 µg/kg N/R TXAPA9 21,315,1972
oral
mouse
lethal dose (50 percent kill): 707 mg/kg N/R NTIS** PB214-270
oral
rat
lethal dose (50 percent kill): 812 mg/kg N/R AMRL** TR-72-62,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (inhalable, vapor; skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 626,135,2007
TOXICOLOGY REVIEW
MUREAV 626,135,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.5 mg/m3), OCT 2002
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (25 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (10 mg/m3), Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Mutagen

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