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2,6 - Xylidine

RTECS #: ZE9275000

CAS #: 87-62-7


UPDATE: February 2009 MW: 121.20 MF: C8H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 2,6 - dimethylbenzene
  2. 2,6 - Dimethylaniline
  3. 2,6 - Dimethylbenzenamine
  4. 2,6 - Dimethylphenylamine
  5. 2,6 - Xylylamine
  6. 2 - Amino - 1,3 - dimethylbenzene
  1. 2 - Amino - 1,3 - xylene
  2. 2 - Amino - m - xylene
  3. Aniline, 2,6 - dimethyl -
  4. DMA
  5. NCI - C56188


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1 gm/L EMMUEG 10(Suppl 10),1,1987
DNA adduct oral
rat
2,170 mg/kg/7 day TOXID9 78,391,2004
mutation in microorganisms Salmonella typhimurium 50 µmol/plate (-enzymatic activation step) JAFCAU 34,157,1986
phage inhibition capacity Escherichia coli 39 µg/well MUREAV 260,349,1991
sister chromatid exchange hamster ovary 301 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 107 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Tumors
NTPTR* NTP-TR-278,1990
oral
rat
lowest published toxic dose: 27,846 mg/kg/26 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Tumorigenic: Facilitates action of known carcinogens
TOPADD 15,39,2002
oral
rat
lowest published toxic dose: 131,040 mg/kg/104 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTIS** PB90-256363
oral
rat
lowest published toxic dose: 109,200 mg/kg/104 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Liver: Tumors
NTIS** PB90-256363
oral
rat
lowest published toxic dose: 65,520 mg/kg/52 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 142,161,1999


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 707 mg/kg N/R NTIS** PB214-270
oral
rat
lethal dose (50 percent kill): 840 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Changes in spleen
TXAPA9 22,153,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 65.52 gm/kg/26 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTPAE7 16,25,2003
oral
mouse
lowest published toxic dose: 89.04 gm/kg/53 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTPAE7 16,25,2003
oral
mouse
lowest published toxic dose: 85.68 gm/kg/51 week- continuous Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 16,41,2003
oral
rat
lowest published toxic dose: 3,150 mg/kg/20 day- continuous Blood: Changes in spleen FAATDF 3,285,1983
oral
rat
lowest published toxic dose: 6,200 mg/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-278,1990
oral
rat
lowest published toxic dose: 13,300 mg/kg/4 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXCYAC 12,63,1979
oral
rat
lowest published toxic dose: 20,150 mg/kg/13 week- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Blood: Changes in other cell count (unspecified)
NTPTR* NTP-TR-278,1990
oral
rat
lowest published toxic dose: 6 gm/kg/4 week- continuous Eye: Other eye effects JTSCDR 25,105,2000
oral
rat
lowest published toxic dose: 5,600 mg/kg/4 week- intermittent Olfaction: Other olfaction effects JTSCDR 25,105,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (inhalable, vapor; skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 57,323,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,323,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 57,323,1993
TOXICOLOGY REVIEW
HETOEA 25,413,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.5 mg/m3), OCT 2002
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (25 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7951;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 5;
Total Number of Employees Exposed 4,354;
Total Number of Female Employees Exposed 729


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for manufacture of pesticides, dyestuffs, antioxidants, pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat


REFERENCES:

CODEN
REFERENCE

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as intermediate for manufacture of pesticides, dyestuffs, antioxidants, pharmaceuticals

RTECS Compound Description:
   Tumorigen
   Mutagen
   Natural Product

Click Here for Additional Information about RTECS

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