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Registry of Toxic Effects of Chemical Substances (RTECS)

2,6-Xylidine

RTECS #

ZE9275000

CAS #

87-62-7

Updated

December 2012

Molecular Weight

121.20

Molecular Formula

C8H11N

Synonyms

1-Amino-2,6-dimethylbenzene
2,6-Dimethylaniline
2,6-Dimethylbenzenamine
2,6-Dimethylphenylamine
2,6-Xylylamine
2-Amino-1,3-dimethylbenzene
2-Amino-1,3-xylene
2-Amino-m-xylene
Aniline, 2,6-dimethyl-
DMA
NCI-C56188

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1 gm/LEMMUEG 10(Suppl 10),1,1987
DNA adductoral/rat2170 mg/kg/7DTOXID9 78,391,2004
mutation in microorganisms/Salmonella typhimurium50 µmol/plate (-enzymatic activation step)JAFCAU 34,157,1986
phage inhibition capacity/Escherichia coli39 µg/wellMUREAV 260,349,1991
sister chromatid exchangeovary/hamster301 mg/LEMMUEG 10(Suppl 10),1,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 107 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Tumors
NTPTR* NTP-TR-278,1990
oral/rat lowest published toxic dose: 27846 mg/kg/26W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Tumorigenic: Facilitates action of known carcinogens
TOPADD 15,39,2002
oral/rat lowest published toxic dose: 131040 mg/kg/104W- continuousTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTIS** PB90-256363
oral/rat lowest published toxic dose: 109200 mg/kg/104W- continuousTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Liver: Tumors
NTIS** PB90-256363
oral/rat lowest published toxic dose: 65520 mg/kg/52W- continuousTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 142,161,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 707 mg/kgNTIS** PB214-270
oral/rat lethal dose (50 percent kill): 840 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Changes in spleen
TXAPA9 22,153,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 65.52 gm/kg/26W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJTPAE7 16,25,2003
oral/mouse lowest published toxic dose: 89.04 gm/kg/53W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJTPAE7 16,25,2003
oral/mouse lowest published toxic dose: 85.68 gm/kg/51W- continuousOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 16,41,2003
oral/rat lowest published toxic dose: 3150 mg/kg/20D- continuousBlood: Changes in spleenFAATDF 3,285,1983
oral/rat lowest published toxic dose: 6200 mg/kg/2W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-278,1990
oral/rat lowest published toxic dose: 13300 mg/kg/4W- intermittentLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXCYAC 12,63,1979
oral/rat lowest published toxic dose: 20150 mg/kg/13W- intermittentBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Blood: Changes in other cell count (unspecified)
NTPTR* NTP-TR-278,1990
oral/rat lowest published toxic dose: 6 gm/kg/4W- continuousEye: Other eye effectsJTSCDR 25,105,2000
oral/rat lowest published toxic dose: 5600 mg/kg/4W- intermittentOlfaction: Other olfaction effectsJTSCDR 25,105,2000

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 57,323,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 57,323,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 57,323,1993
TOXICOLOGY REVIEWHETOEA 25,413,2006
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.5 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (25 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, JAN1999

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7951; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 5; Total Number of Employees Exposed 4354; Total Number of Female Employees Exposed 729

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat
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