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Registry of Toxic Effects of Chemical Substances (RTECS)

2,5-Xylidine

RTECS #

ZE9100000

CAS #

95-78-3

Updated

July 2013

Molecular Weight

121.20

Molecular Formula

C8H11N

Synonyms

1-Amino-2,5-dimethylbenzene
2,5-Dimethylaniline
2,5-Dimethylbenzenamine
2,5-Dimethylphenylamine
2-Amino-1,4-xylene
3-Amino-1,4-dimethylbenzene
5-Methyl-o-toluidine
6-Methyl-m-toluidine
Aniline, 2,5-dimethyl-
p-Xylidine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
mutation in microorganisms/Salmonella typhimurium10 µmol/plate (-enzymatic activation step)MUREAV 77,317,1980
Unscheduled DNA Synthesisliver/rat10 µmol/LMUREAV 221,263,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 841 mg/kgNTIS** PB214-270
oral/rat lethal dose (50 percent kill): 1120 mg/kgGISAAA 11,16,1993

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 13300 mg/kg/4W- intermittentLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXCYAC 12,63,1979

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 16,377,1978
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 16,377,1978
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (25 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (10 mg/m3), skin, JAN2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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