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Registry of Toxic Effects of Chemical Substances (RTECS)

2,4-Xylidine

RTECS #

ZE8925000

CAS #

95-68-1

Updated

April 2012

Molecular Weight

121.20

Molecular Formula

C8H11N

Synonyms

1-Amino-2,4-dimethylbenzene
2,4-Dimethylaniline
2,4-Dimethylbenzenamine
2,4-Dimethylphenylamine
2-Methyl-p-toluidine
4-Amino-1,3-dimethylbenzene
4-Amino-1,3-xylene
4-Amino-3-methyltoluene
4-Methyl-o-toluidine
Aniline, 2,4-dimethyl-
m-4-Xylidine
m-Xylidine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageintraperitoneal/mouse100 mg/kgCALEDQ 147,1,1999
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (-enzymatic activation step)JAFCAU 34,157,1986
Unscheduled DNA Synthesisliver/rat1 µmol/LMUREAV 206,183,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 149 ppm/7H85INA8 6,1743,1991
oral/mouse lethal dose (50 percent kill): 250 mg/kgNTIS** PB214-270
oral/rat lethal dose (50 percent kill): 467 mg/kgNTIS** PB214-270

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1170 mg/kg/10D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 3,285,1983
oral/rat lowest published toxic dose: 13300 mg/kg/4W- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXCYAC 12,63,1979

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 16,367,1978
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 16,367,1978
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 5 ppm (25 mg/m3);KZW 20 ppm (100 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (25 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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