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Registry of Toxic Effects of Chemical Substances (RTECS)

2,3-Xylidine

RTECS #

ZE8750000

CAS #

87-59-2

Updated

July 2013

Molecular Weight

121.20

Molecular Formula

C8H11N

Synonyms

2,3-Dimethylaniline
2,3-Dimethylbenzenamine
2,3-Dimethylphenylamine
2,3-Xylylamine
Benzenamine, 2,3-dimethyl- (9CI)
o-Xylidine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (+enzymatic activation step)MUREAV 517,187,2002
mutation in microorganisms/Salmonella typhimurium5 µmol/plate (-enzymatic activation step)MUREAV 77,317,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 836 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
PWPSA8 6,11,1963
oral/rat lethal dose (50 percent kill): 933 mg/kgNTIS** PB214-270

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (25 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (10 mg/m3), skin, JAN2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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