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Registry of Toxic Effects of Chemical Substances (RTECS)

3,5-Xylenol

RTECS #

ZE6475000

CAS #

108-68-9

Updated

January 2010

Molecular Weight

122.18

Molecular Formula

C8H10O

Synonyms

1,3,5-Xylenol
3,5-Dimethylphenol
4,4'-Methylenediphenyl diisocyanate
Phenol, 3,5-dimethyl- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg severeAJOPAA 29,1363,1946

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 9 mg/m3/6H (6-15D pregnant)Reproductive: Other effects on femaleNTIS** OTS0557594

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 4000 mg/kg/20W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >4 mg/m3GTPZAB 23(10),52,1979
inhalation/rat lowest published toxic concentration: 4 mg/m3Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchiVCVGK* -,204,1994
intraperitoneal/mouse lethal dose (50 percent kill): 156 mg/kgJMCMAR 18,868,1975
oral/mouse lethal dose (50 percent kill): 477 mg/kgBehavioral: Ataxia

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 33(7-9),329,1968
oral/mouse lethal dose (50 percent kill): 477 mg/kgVCVGK* -,205,1994
oral/rabbit lethal dose (50 percent kill): 1313 mg/kgVCVGK* -,205,1994
oral/rabbit lethal dose (50 percent kill): 1313 mg/kgBehavioral: Ataxia

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 33(7-9),329,1968
oral/rat lethal dose (50 percent kill): 608 mg/kgHPV299 -,-,2002
oral/rat lethal dose (50 percent kill): 608 mg/kgVCVGK* -,205,1994

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1583; Number of Industries 2; Total Number of Facilities 61; Number of Occupations 2; Total Number of Employees Exposed 136; Total Number of Female Employees Exposed 56

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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