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Registry of Toxic Effects of Chemical Substances (RTECS)

2,4-Xylenol

RTECS #

ZE5600000

CAS #

105-67-9

Updated

January 2010

Molecular Weight

122.18

Molecular Formula

C8H10O

Synonyms

1-Hydroxy-2,4-dimethylbenzene
2,4-Dimethylphenol
4,6-Dimethylphenol
m-Xylenol
Phenol, 2,4-dimethyl- (9CI)
RCRA waste number U101
Xylenol

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 16 gm/kg/39W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >30 mg/m3GTPZAB 23(10),52,1979
inhalation/rat lowest published toxic concentration: 26 mg/m3Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchiVCVGK* -,204,1994
intraperitoneal/mouse lethal dose (50 percent kill): 183 mg/kgJMCMAR 18,868,1975
intravenous/mouse lethal dose (50 percent kill): 100 mg/kgBehavioral: SleepJMCMAR 23,1350,1980
oral/mouse lethal dose (50 percent kill): 809 mg/kgTOBHB* VI:137,1,1995
oral/rat lethal dose (50 percent kill): 2300 mg/kgHPV299 -,-,2002
skin/rat lethal dose (50 percent kill): 1040 mg/kgTOBHB* VI:137,1,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 23 mg/m3/4H/30D- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,205,1994
oral/mouse lowest published toxic dose: 22500 mg/kg/90D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
HPV299 -,-,2002
oral/rat lowest published toxic dose: 6 gm/kg/10D- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count
DCTODJ 16,351,1993
oral/rat lowest published toxic dose: 48600 mg/kg/90D- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 16,351,1993
oral/rat lowest published toxic dose: 8400 mg/kg/4W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in testicular weight
TOBHB* VI:137,1,1995
oral/rat lowest published toxic dose: 8400 mg/kg/4W- intermittentVascular: Regional or general arteriolar or venous dilation

Liver: Other changes

Liver: Changes in liver weight
TOBHB* VI:137,1,1995
oral/rat lowest published toxic dose: 2800 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in kidney weightTOBHB* VI:137,1,1995
oral/rat lowest published toxic dose: 15120 mg/kg/12W- intermittentGastrointestinal: GastritisTOBHB* VI:137,1,1995
skin/mouse lowest published toxic dose: 366.5 mg/kg/3D- continuousImmunological Including Allergic: Increase in cellular immune responseTXCYAC 232,132,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,345,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2332; Number of Industries 7; Total Number of Facilities 736; Number of Occupations 8; Total Number of Employees Exposed 12254; Total Number of Female Employees Exposed 786

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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