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Registry of Toxic Effects of Chemical Substances (RTECS)

Vondozeb

RTECS #

ZB3200000

CAS #

8018-01-7; 8064-36-6; 8065-67-6; 12001-34-2; 62712-14-5; 84070-12-2

Updated

July 2013

Molecular Weight

541.03

Molecular Formula

C4H6MnN2S4·C4H6N2S4Zn

Synonyms

Agrox 16D
Carbamic acid, ethylenebis(dithio-, manganese zinc complex (8CI)
Carmazine
Dithane M 45
Dithane S 60
Dithane SPC
Dithane ultra
F 2966
Fore
Green-daisen M
Karamate
Kascade
Mancofol
Mancomix
Mancozeb
Mancozi
Maneb-zinc
Maneb-zineb-komplex (German)
Maneb-zineb-mischkomplex (German)
Mangan-zink-aethylendiamin-bis-dithio-carbamat (German)
Manoseb
Manzate 200
Manzeb
Manzin 80
Marzidan
Marzin
Nemispor
Novozir MN 80
Othane M 45
Penncozeb
Tanzeo M45
Thane M45
Tritogol MZ
Zimanat
Ziman-Dithane
Zimaneb
Zineb-maneb mixt.

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human4 mg/LMUREAV 116,341,1983
Cytogenetic Analysisintraperitoneal/rat2500 µg/kgMUREAV 116,341,1983
Cytogenetic Analysisoral/rat476 mg/kg/40W- intermittentMUREAV 116,341,1983
Cytogenetic Analysisunreported route/mouse100 mg/kgTGANAK 16(1),45,1982
DNA Damagefibroblast/rat125 µg/L/1HTXAPA9 211,87,2006
DNA Damageleukocyte/rat125 µg/L/1HTXAPA9 211,87,2006
gene conversion and mitotic recombination/Saccharomyes cerevisiae50 ppmNTIS** PB85-193761
mutation in microorganisms/Aspergillus nidulans12 mg/L (-enzymatic activation step)MUREAV 176,29,1987
mutation in microorganisms/Saccharomyes cerevisiae5 ppm (-enzymatic activation step)RSTUDV 6,161,1976
Unscheduled DNA Synthesisfibroblast/human10 mg/LNTIS** PB85-193761
Unscheduled DNA Synthesisskin/mouse100 mg/kgCRNGDP 13,131,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 500 mg/m3/6H (6-10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 84,355,1986
oral/rat 1320 mg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
TJADAB 14,171,1976
oral/rat 1320 mg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
TJADAB 14,171,1976
unreported route/rat 2500 mg/kg (5D male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
KHZDAN 27,524,1984

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 17700 mg/kg/60W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CALEDQ 53,191,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 5 gm/kg85JFAN A251,1986
skin/rabbit lethal dose (50 percent kill): >5 gm/kgPEMNDP 9,530,1991
skin/rat lethal dose (50 percent kill): >10 gm/kg85JFAN A251,1986
Tank with water/Daphnia lethal concentration (50 percent kill): 1.3 mg/L/48HAQUTO* 7,145,1985
Tank with water/Guppy lethal concentration (50 percent kill): 2.6 mg/L/96HAQUTO* 7,145,1985

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 4000 mg/kg/5D- intermittentBehavioral: Alteration of classical conditioningETOPFR 15,9,2003
oral/mouse lowest published toxic dose: 8000 mg/kg/10D- intermittentEndocrine: Changes in thymus weightETOPFR 15,9,2003
oral/mouse lowest published toxic dose: 16 gm/kg/20D- intermittentRelated to Chronic Data: Changes in testicular weight

Liver: Changes in liver weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
ETOPFR 15,9,2003
oral/mouse lowest published toxic dose: 24 gm/kg/30D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Endocrine: Changes in thyroid weight
ETOPFR 15,9,2003
oral/rat lowest published toxic dose: 4000 mg/kg/4D- intermittentLiver: Changes in liver weightTOXID9 66,339,2002
oral/rat lowest published toxic dose: 1000 mg/kg/4D- intermittentEndocrine: Evidence of thyroid hypofunctionTOXID9 66,339,2002
oral/rat lowest published toxic dose: 6300 mg/kg/12W- continuousEndocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FCTOD7 27,531,1989
oral/rat lowest published toxic dose: 45 gm/kg/90D- intermittentEndocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
IJEBA6 31,564,1993
oral/rat lowest published toxic dose: 5250 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
IJEBA6 29,943,1991
oral/rat lowest published toxic dose: 180 gm/kg/1Y- intermittentGastrointestinal: Hypermotility, diarrhea

Endocrine: Changes in thyroid weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JJATDK 17,369,1997

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWMUREAV 543,251,2003
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWFEREAC 74,47507,2009
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWREPTED 33,188,2012
TOXICOLOGY REVIEWREPTED 33,269,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,129,1998
Mine Safety and Health Administration (MSHA) STANDARD-airceiling concentration 5 mg(Mn)/m3DTLVS* 3,149,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg(Mn)/m3, MAR2002
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Mn)/m3 (resp), 0.2 mg(Mn)/m3 (inhal), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg(Mn)/m3, short term exposure limit 20 mg(Mn)/m3, SEP2000
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Mn)/m3;short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(Mn)/m3, JAN1993
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Mn)/m3, inhal, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Mn)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 5 mg(Mn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1915.1000,1993

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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