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Vondozeb

RTECS #: ZB3200000

CAS #: 8018-01-7


UPDATE: May 2009 MW: 541.03 MF: C4H6MnN2S4C4H6N2S4Zn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Agrox 16D
  2. Carbamic acid, ethylenebis (dithio - , manganese zinc complex (8CI)
  3. Carmazine
  4. Dithane M 45
  5. Dithane S 60
  6. Dithane SPC
  7. Dithane ultra
  8. F 2966
  9. Fore
  10. Green - daisen M
  11. Karamate
  12. Kascade
  13. Mancofol
  14. Mancomix
  15. Mancozeb
  16. Mancozi
  17. Maneb - zinc
  18. Maneb - zineb - komplex (German)
  19. Maneb - zineb - mischkomplex (German)
  1. Mangan - zink - aethylendiamin - bis - dithio - carbamat (German)
  2. Manoseb
  3. Manzate 200
  4. Manzeb
  5. Manzin 80
  6. Marzidan
  7. Marzin
  8. Nemispor
  9. Novozir MN 80
  10. Othane M 45
  11. Penncozeb
  12. Tanzeo M45
  13. Thane M45
  14. Tritogol MZ
  15. Ziman - Dithane
  16. Zimanat
  17. Zimaneb
  18. Zineb - maneb mixt.


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 4 mg/L MUREAV 116,341,1983
cytogenetic analysis unreported route
mouse
100 mg/kg TGANAK 16(1),45,1982
cytogenetic analysis intraperitoneal
rat
2,500 g/kg MUREAV 116,341,1983
cytogenetic analysis oral
rat
476 mg/kg/40 week- intermittent MUREAV 116,341,1983
DNA damage rat fibroblast 125 g/L/1 hour TXAPA9 211,87,2006
DNA damage rat leukocyte 125 g/L/1 hour TXAPA9 211,87,2006
unscheduled DNA synthesis human fibroblast 10 mg/L NTIS** PB85-193761
unscheduled DNA synthesis skin
mouse
100 mg/kg CRNGDP 13,131,1992
mutation in microorganisms Aspergillus nidulans 12 mg/L (-enzymatic activation step) MUREAV 176,29,1987
mutation in microorganisms Saccharomyes cerevisiae 5 ppm (-enzymatic activation step) RSTUDV 6,161,1976
gene conversion and mitotic recombination Saccharomyes cerevisiae 50 ppm NTIS** PB85-193761


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 500 mg/m3/6 hour (6-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 84,355,1986
oral
rat
lowest published toxic dose: 1,320 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
TJADAB 14,171,1976
oral
rat
lowest published toxic dose: 1,320 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
TJADAB 14,171,1976
unreported route
rat
lowest published toxic dose: 2,500 mg/kg (5 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
KHZDAN 27,524,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 17,700 mg/kg/60 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CALEDQ 53,191,1990


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lethal dose (50 percent kill): 5 gm/kg N/R 85JFAN A251,1986
skin
rat
lethal dose (50 percent kill): >10 gm/kg N/R 85JFAN A251,1986
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,530,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 4,000 mg/kg/5 day- intermittent Behavioral: Alteration of classical conditioning ETOPFR 15,9,2003
oral
mouse
lowest published toxic dose: 8,000 mg/kg/10 day- intermittent Endocrine: Changes in thymus weight ETOPFR 15,9,2003
oral
mouse
lowest published toxic dose: 16 gm/kg/20 day- intermittent Related to Chronic Data: Changes in testicular weight

Liver: Changes in liver weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
ETOPFR 15,9,2003
oral
mouse
lowest published toxic dose: 24 gm/kg/30 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Endocrine: Changes in thyroid weight
ETOPFR 15,9,2003
oral
rat
lowest published toxic dose: 6,300 mg/kg/12 week- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FCTOD7 27,531,1989
oral
rat
lowest published toxic dose: 45 gm/kg/90 day- intermittent Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
IJEBA6 31,564,1993
oral
rat
lowest published toxic dose: 5,250 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport
IJEBA6 29,943,1991
oral
rat
lowest published toxic dose: 180 gm/kg/1 year- intermittent Gastrointestinal: Hypermotility, diarrhea

Endocrine: Changes in thyroid weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JJATDK 17,369,1997
oral
rat
lowest published toxic dose: 4,000 mg/kg/4 day- intermittent Liver: Changes in liver weight TOXID9 66,339,2002
oral
rat
lowest published toxic dose: 1,000 mg/kg/4 day- intermittent Endocrine: Evidence of thyroid hypofunction TOXID9 66,339,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
MUREAV 562,77,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
HUTOX* -,561,1996
TOXICOLOGY REVIEW
MUREAV 543,251,2003
TOXICOLOGY REVIEW
MUREAV 543,251,2003
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,129,1998
Mine Safety and Health Administration (MSHA) STANDARD - air ceiling concentration 5 mg(Mn)/m3 DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Mn)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (dust), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (fume), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Mn)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg(Mn)/m3, short term exposure limit 20 mg(Mn)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg(Mn)/m3 (respirable dust), APR2007
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Mn)/m3;
short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit - MEXICO time-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Mn)/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Mn)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
Used as a fungicide
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HTOPA*
HUTOX*
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a fungicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 8064-36-6
ALT CAS #: 8065-67-6
ALT CAS #: 12001-34-2
ALT CAS #: 62712-14-5
ALT CAS #: 84070-12-2
Click Here for Additional Information about RTECS

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