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Registry of Toxic Effects of Chemical Substances (RTECS)

Vanillin

RTECS #

YW5775000

CAS #

121-33-5

Updated

December 2013

Molecular Weight

152.16

Molecular Formula

C8H8O3

Synonyms

3-Methoxy-4-hydroxybenzaldehyde
4-Hydroxy-3-methoxybenzaldehyde
Benzaldehyde, 4-hydroxy-3-methoxy-
Lioxin
m-Anisaldehyde, 4-hydroxy-
Methylprotocatechuic aldehyde
p-Hydroxy-m-methoxybenzaldehyde
Protocatechualdehyde, methyl-
p-Vanillin
Vanilla
Vanillaldehyde
Vanillic aldehyde
Vanilline
Zimco

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human4 mmol/LMUREAV 190,221,1987
DNA Damageother cell types/human2.5 mmol/L/4HMUREAV 577S,1,2005
sister chromatid exchangelymphocyte/human1 mmol/L/88H (+enzymatic activation step)HPV141 -,-,2001
sister chromatid exchangelymphocyte/human750 µmol/LMUREAV 169,129,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat 20 mg/kg (4D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
JSICAZ 19,264,1960

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lethal concentration: >41700 µg/kg/2HGISAAA 45(6),78,1980
inhalation/rat Lethal concentration: >41700 µg/kg/4HGISAAA 45(6),78,1980
intraperitoneal/guinea pig lethal dose (50 percent kill): 1190 mg/kgENTOX* -,418,2005
intraperitoneal/mouse lethal dose (50 percent kill): 475 mg/kgENTOX* -,418,2005
intraperitoneal/rat lethal dose (50 percent kill): 1160 mg/kgENTOX* -,418,2005
intravenous/Dog lowest published lethal dose: 1320 mg/kgVascular: BP lowering not characterized in autonomic section

Vascular: Acute arterial occulsion

Lung, Thorax, or Respiration: Other changes
COREAF 236,2549,1953
oral/guinea pig lethal dose (50 percent kill): 1400 mg/kgENTOX* -,418,2005
oral/guinea pig lethal dose (50 percent kill): 1400 mg/kgBehavioral: Somnolence (general depressed activity)HPV141 -,-,2001
oral/mouse lethal dose (50 percent kill): 1000 mg/kgHPV141 -,-,2001
oral/mouse lethal dose (50 percent kill): 3925 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma
NTIS** OTS0536271
oral/rabbit lowest published lethal dose: 3 gm/kgJAPMA8 29,425,1940
oral/rat lethal dose (50 percent kill): 1580 mg/kgENTOX* -,418,2005
oral/rat lethal dose (50 percent kill): 1580 mg/kgBehavioral: ComaHPV141 -,-,2001
rectal/mouse lowest published toxic dose: 90565 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJPETAB 330,370,2009
skin/rabbit lethal dose (50 percent kill): >5010 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Gastrointestinal: Peritonitis
NTIS** OTS0533712
skin/rat Lethal dose: >2 gm/kgLiver: Jaundice, other or unclassifiedNTIS** OTS0536272
subcutaneous/rat lethal dose (50 percent kill): 1500 mg/kgEye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation
RMSRA6 16,449,1896
subcutaneous/rat lethal dose (50 percent kill): 1500 mg/kgENTOX* -,418,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 41700 µg/m3/4H/30D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
GISAAA 45(6),78,1980
inhalation/rat lowest published toxic concentration: 1.5 mg/m3/16W- intermittentCardiac: Other changes

Liver: Other changes

Blood: Other changes
HPV141 -,-,2001
oral/mouse lowest published toxic dose: 108.9 mg/kg/3D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJPETAB 330,370,2009
oral/rat lowest published toxic dose: 21 mg/kg/7D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)FCTOD7 50,1897,2012
oral/rat lowest published toxic dose: 4480 mg/kg/70D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainVCVGK* -,399,1994
oral/rat lowest published toxic dose: 4480 mg/kg/70D- intermittentCardiac: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPMA8 29,425,1940
oral/rat lowest published toxic dose: 273 gm/kg/13W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
38MKAJ 2A,2540,1981

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTXAV 15,611,1977
TOXICOLOGY REVIEWENTOX* -,418,2005
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWFCTOD7 50,2243,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1.5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0609; Number of Industries 89; Total Number of Facilities 10912; Number of Occupations 97; Total Number of Employees Exposed 177946; Total Number of Female Employees Exposed 69887
National Occupational Hazard Survey 1974Hazard Code M0609; Number of Industries 14; Total Number of Facilities 378; Number of Occupations 28; Total Number of Employees Exposed 6740

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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