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Vanillin

RTECS #: YW5775000

CAS #: 121-33-5


UPDATE: May 2009 MW: 152.16 MF: C8H8O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 3 - Methoxy - 4 - hydroxybenzaldehyde
  2. 4 - Hydroxy - 3 - methoxybenzaldehyde
  3. Benzaldehyde, 4 - hydroxy - 3 - methoxy -
  4. Lioxin
  5. Methylprotocatechuic aldehyde
  6. Protocatechualdehyde, methyl -
  7. Vanilla
  1. Vanillaldehyde
  2. Vanillic aldehyde
  3. Vanilline
  4. Zimco
  5. m - Anisaldehyde, 4 - hydroxy -
  6. p - Hydroxy - m - methoxybenzaldehyde
  7. p - Vanillin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 4 mmol/L MUREAV 190,221,1987
DNA damage human other cell types 2.5 mmol/L/4 hour MUREAV 577S,1,2005
sister chromatid exchange human lymphocyte 750 mol/L MUREAV 169,129,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rat
lowest published toxic dose: 20 mg/kg (4 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
JSICAZ 19,264,1960


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration : >41,700 g/kg/2 hour N/R GISAAA 45(6),78,1980
inhalation
rat
lethal concentration : >41,700 g/kg/4 hour N/R GISAAA 45(6),78,1980
intraperitoneal
guinea pig
lethal dose (50 percent kill): 1,190 mg/kg N/R ENTOX* -,418,2005
intraperitoneal
mouse
lethal dose (50 percent kill): 475 mg/kg N/R ENTOX* -,418,2005
intraperitoneal
rat
lethal dose (50 percent kill): 1,160 mg/kg N/R ENTOX* -,418,2005
intravenous
dog
lowest published lethal dose: 1,320 mg/kg Vascular: BP lowering not characterized in autonomic section

Vascular: Acute arterial occulsion

Lung, Thorax, or Respiration: Other changes
COREAF 236,2549,1953
oral
guinea pig
lethal dose (50 percent kill): 1,400 mg/kg Behavioral: Somnolence (general depressed activity) FCTXAV 2,327,1964
oral
guinea pig
lethal dose (50 percent kill): 1,400 mg/kg N/R ENTOX* -,418,2005
oral
mouse
lethal dose (50 percent kill): 3,925 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma
NTIS** OTS0536271
oral
mouse
lethal dose (50 percent kill): 1,480 mg/kg N/R VCVGK* -,399,1984
oral
rat
lethal dose (50 percent kill): 1,580 mg/kg Behavioral: Coma FCTXAV 2,327,1964
oral
rat
lethal dose (50 percent kill): 1,580 mg/kg N/R ENTOX* -,418,2005
oral
rabbit
lowest published lethal dose: 3 gm/kg N/R JAPMA8 29,425,1940
subcutaneous
rat
lethal dose (50 percent kill): 1,500 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation
RMSRA6 16,449,1896
subcutaneous
rat
lethal dose (50 percent kill): 1,500 mg/kg N/R ENTOX* -,418,2005
skin
rat
lethal dose : >2 gm/kg Liver: Jaundice, other or unclassified NTIS** OTS0536272
skin
rabbit
lethal dose (50 percent kill): >5,010 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Gastrointestinal: Peritonitis
NTIS** OTS0533712


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 41,700 g/m3/4 hour/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
GISAAA 45(6),78,1980
oral
rat
lowest published toxic dose: 4,480 mg/kg/70 day- intermittent Cardiac: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPMA8 29,425,1940
oral
rat
lowest published toxic dose: 273 gm/kg/13 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
38MKAJ 2A,2540,1981
oral
rat
lowest published toxic dose: 4,480 mg/kg/70 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,399,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FCTXAV 15,611,1977
TOXICOLOGY REVIEW
ENTOX* -,418,2005
TOXICOLOGY REVIEW
HUTOX* -,259,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 1.5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0609;
Number of Industries 14;
Total Number of Facilities 378;
Number of Occupations 28;
Total Number of Employees Exposed 6,740
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0609;
Number of Industries 89;
Total Number of Facilities 10,912;
Number of Occupations 97;
Total Number of Employees Exposed 177,946;
Total Number of Female Employees Exposed 69,887


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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