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Vanadium trioxide

RTECS #: YW3050000

CAS #: 1314-34-7


UPDATE: February 2003 MW: 149.88 MF: O3V2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Vanadic oxide
  2. Vanadium oxide
  1. Vanadium sesquioxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
5 L/24 hour moderate NTIS** OTS0534591


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 18 mg/L TOLED5 50,327,1990
sister chromatid exchange hamster ovary 1,470 g/L TOLED5 50,327,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratracheal
rat
lowest published lethal dose: 125 mg/kg N/R NTIS** AEC-TR-6710
oral
mouse
lethal dose (50 percent kill): 130 mg/kg N/R 85GMAT -,119,1982
oral
mouse
lethal dose (50 percent kill): 130 mg/kg Cardiac: Other changes

Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVN5* -,126,1993
oral
rat
lethal dose (50 percent kill): 566 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0534591
subcutaneous
mouse
lethal dose (50 percent kill): 130 mg/kg N/R ZVKOA6 19,186,1974
skin
rabbit
lethal dose (50 percent kill): 200 mg/kg Kidney, Ureter, and Bladder: Other changes NTIS** OTS0534591


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 40 mg/m3/2 hour/39 week- intermittent Lung, Thorax, or Respiration: Emphysema

Blood: Normocytic anemia

Blood: Luekopenia
VCVN5* -,131,1989
inhalation
rabbit
lowest published toxic concentration: 40 mg/m3/2 hour/39 week- intermittent Lung, Thorax, or Respiration: Emphysema

Blood: Normocytic anemia

Blood: Luekopenia
VCVN5* -,131,1989
oral
rabbit
lowest published toxic dose: 280 mg/kg/56 day- intermittent Blood: Other changes VCVN5* -,131,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
85DHAX V,46,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(V2O5)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.25 mg(V205)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(V2O5)/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VANADIUM (as V2O5), resp dust/fume-air ceiling concentration 0.05 mg/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1903;
Number of Industries 3;
Total Number of Facilities 84;
Number of Occupations 7;
Total Number of Employees Exposed 851;
Total Number of Female Employees Exposed 18


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Vanadium oxides, 7504


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I. Mendeleeva. Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.5- 1960-

RTECS Compound Description:
   Mutagen
   Primary Irritant

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