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Registry of Toxic Effects of Chemical Substances (RTECS)

Vanadium trioxide

RTECS #

YW3050000

CAS #

1314-34-7

Updated

February 2003

Molecular Weight

149.88

Molecular Formula

O3V2

Synonyms

Vanadic oxide
Vanadium oxide
Vanadium sesquioxide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 µL/24H moderateNTIS** OTS0534591

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster18 mg/LTOLED5 50,327,1990
sister chromatid exchangeovary/hamster1470 µg/LTOLED5 50,327,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intratracheal/rat lowest published lethal dose: 125 mg/kgNTIS** AEC-TR-6710
oral/mouse lethal dose (50 percent kill): 130 mg/kg85GMAT -,119,1982
oral/mouse lethal dose (50 percent kill): 130 mg/kgCardiac: Other changes

Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVN5* -,126,1993
oral/rat lethal dose (50 percent kill): 566 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0534591
skin/rabbit lethal dose (50 percent kill): 200 mg/kgKidney, Ureter, and Bladder: Other changesNTIS** OTS0534591
subcutaneous/mouse lethal dose (50 percent kill): 130 mg/kgZVKOA6 19,186,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 40 mg/m3/2H/39W- intermittentLung, Thorax, or Respiration: Emphysema

Blood: Normocytic anemia

Blood: Luekopenia
VCVN5* -,131,1989
inhalation/rat lowest published toxic concentration: 40 mg/m3/2H/39W- intermittentLung, Thorax, or Respiration: Emphysema

Blood: Normocytic anemia

Blood: Luekopenia
VCVN5* -,131,1989
oral/rabbit lowest published toxic dose: 280 mg/kg/56D- intermittentBlood: Other changesVCVN5* -,131,1989

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEW85DHAX V,46,1974

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.25 mg(V205)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(V2O5)/m3, JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VANADIUM (as V2O5), resp dust/fume-airceiling concentration 0.05 mg/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code A1903; Number of Industries 3; Total Number of Facilities 84; Number of Occupations 7; Total Number of Employees Exposed 851; Total Number of Female Employees Exposed 18

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Vanadium oxides, 7504
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