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Registry of Toxic Effects of Chemical Substances (RTECS)

Vanadium pentoxide

RTECS #

YW2125000

CAS #

1314-62-1

Updated

September 201

Molecular Weight

181.88

Molecular Formula

O5V2

Synonyms

Vanadium (V) oxide

Tumorigenic Data and References

Route/OrganismDoseEffectReference
multiple/mouse lowest published toxic dose: 1 mg/m3/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TOXID9 72,85,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 1 mg/m3/8HLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Sputum

Nutritional and Gross Metabolic: Body temperature increase
VCVN5* -,130,1993
inhalation/rat lowest published toxic concentration: 0.006 mg/m3Behavioral: Muscle weakness

Musculoskeletal: Other changes
HBTME* -,905,2007
intratracheal/mouse lowest published toxic dose: 6.3 mg/kgLung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 66,194,2002
intratracheal/rat lowest published toxic dose: 6.3 mg/kgLung, Thorax, or Respiration: Respiratory depressionTOXID9 66,194,2002
intratracheal/rat lowest published toxic dose: 1 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJPETAB 322,486,2007
intravenous/human lowest published toxic dose: 1.43 mg/kgCardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Proteinuria
HBTME* -,905,2007
intravenous/rabbit lethal dose (50 percent kill): 1 mg/kgVCVN5* -,126,1993
oral/mouse lethal dose (50 percent kill): 23.4 mg/kgCardiac: Other changes

Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVN5* -,126,1993
subcutaneous/guinea pig lethal dose (50 percent kill): 20 mg/kgVCVN5* -,126,1993
subcutaneous/mouse lethal dose (50 percent kill): 85.7 mg/kgVCVN5* -,126,1993

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 2 mg/m3/12D- intermittentLung, Thorax, or Respiration: Changes in lung weightTOSCF2 77,6,2004
inhalation/mouse lowest published toxic concentration: 3.6 mg/m3/1W- intermittentBrain and Coverings: Other degenerative changesTOXID9 44,124,2005
inhalation/mouse lowest published toxic concentration: 3638 gm/m3/12W- intermittentBlood: Changes in spleenTOXID9 44,236,2005
inhalation/mouse lowest published toxic concentration: 1.82 mg/m3/4W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOXID9 66,34,2002
inhalation/mouse lowest published toxic concentration: 3640 gm/m3/4W- intermittentBlood: Changes in spleenTOXID9 -,326,2009
inhalation/mouse lowest published toxic concentration: 3640 gm/m3/12W- intermittentCardiac: Cardiomyopathy including infarctionTOXID9 -,327,2009
inhalation/rat lowest published toxic concentration: 1 mg/m3/12D- intermittentLung, Thorax, or Respiration: Changes in lung weightTOSCF2 77,6,2004
intratracheal/rat lowest published toxic dose: 1600 µg/kg/2D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 60,196,2001
intratracheal/rat lowest published toxic dose: 6.72 mg/kg/48W- intermittentEndocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
HBTME* -,905,2007
multiple/mouse lowest published toxic concentration: 1 mg/m3/90D- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Changes in lung weight
TOXID9 72,85,2003
multiple/mouse lowest published toxic concentration: 1 mg/m3/2Y- continuousLung, Thorax, or Respiration: Fibrosing alveolitisTOXID9 72,85,2003
multiple/rat lowest published toxic concentration: 1 mg/m3/90D- continuousLung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Changes in lung weight
TOXID9 72,85,2003
oral/rat lowest published toxic dose: 4 mg(V)/kg/80D- intermittentBehavioral: Alteration of classical conditioningHBTME* -,905,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg(V)/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review: Group 2BIMEMDT 86,278,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 659,248,2008
TOXICOLOGY REVIEWHBTME* ,905,2007
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWMUREAV 674,31,2009
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWIMEMDT 86,243,
TOXICOLOGY REVIEWMUREAV 705,184,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg/m3 (resp. dust, fume), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.03 mg(V)/m3 (dust, fume), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 mg/m3 (dust, fume), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.05 mg/m3 (resp), short term exposure limit 0.2 mg/m3 (resp), SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg(V)/m3 (dust, fume), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg/m3, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3 (respirable, fume), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg/m3 (respirable dust and fume), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.2 mg(V)/m3 (total dust);ceiling concentration 0.05 mg(V)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.05 mg/m3, resp, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.05 mg/m3, OCT2007
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