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Valeric acid

RTECS #: YV6100000

CAS #: 109-52-4


UPDATE: February 2006 MW: 102.15 MF: C5H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Butanecarboxylic acid
  2. Butanecarboxylic acid
  3. Kyselina valerova (Czech)
  4. Pentanoic acid
  1. Propylacetic acid
  2. Valerianic acid
  3. n - Pentanoic acid
  4. n - Valeric acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** OTS0571218


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 4,100 mg/m3/2 hour N/R 85GMAT -,119,1982
intraperitoneal
mouse
lethal dose (50 percent kill): 3,590 mg/kg N/R JPPMAB 21,85,1969
intravenous
mouse
lethal dose (50 percent kill): 1,290 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
APTOA6 18,141,1961
oral
mouse
lethal dose (50 percent kill): 600 mg/kg N/R 85GMAT -,119,1982
subcutaneous
mouse
lethal dose (50 percent kill): 3,590 mg/kg N/R JPPMAB 21,85,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
AMIHAB 21,100,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84212;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 3;
Total Number of Employees Exposed 497
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84212;
Number of Industries 2;
Total Number of Facilities 79;
Number of Occupations 8;
Total Number of Employees Exposed 4,510;
Total Number of Female Employees Exposed 780


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a perfumery
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as a perfumery

RTECS Compound Description:
   Reproductive Effector

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