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Registry of Toxic Effects of Chemical Substances (RTECS)

Urea, 3-(3,4-dichlorophenyl)-1-methoxy-1-methyl-

RTECS #

YS9100000

CAS #

330-55-2

Updated

July 2012

Molecular Weight

249.11

Molecular Formula

C9H10Cl2N2O2

Synonyms

1-(3,4-Dichlorophenyl)3-methoxy-3-methyluree (French)
1-Methoxy-1-methyl-3-(3,4-dichlorophenyl)urea
3-(3,4-Dichloor-fenyl)-1-methoxy-1-methylureum (Dutch)
3-(3,4-Dichloro-fenil)-1-metossi-1-metil-urea (Italian)
3-(3,4-Dichlorophenyl)-1-methoxy-1-methylurea
3-(3,4-Dichlorophenyl)-1-methoxymethylurea
3-(3,4-Dichlor-phenyl)-1-methoxy-1-methyl-harnstoff (German)
3-(4,5-Dichlorphenyl)-1-methoxy-1-methylharnstoff (German)
Afalon
Afalon inuron
Aphalon
Cephalon
Du Pont 326
Dupont herbicide 326
Garnitan
Herbicide 326
HOE 2810
Laroks (Polish)
Linex 4L
Linorox
Linurex
Linuron
Linuron (herbicide)
Lorex
Lorox
Lorox linuron weed killer
Methoxydiuron
N'-(3,4-Dichlorophenyl)-N-methoxy-N-methylurea
N-(3,4-Dichlorophenyl)-N'-methyl-N'-methoxyurea
N-(3,4-Dwuchlorofenylo)N'-metoksy-N'-metylomocznik (Polish)
Sarclex
Scarclex
Sinuron

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/rat4500 mg/kg/2W- intermittentMUREAV 390,207,1997
DNA inhibitionoral/mouse500 mg/kgMUREAV 58,353,1978

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 21.6876 mg/kg (62D male)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TXAPA9 119,195,1993
oral/rat 132.06 mg/kg (62D male)Reproductive: Specific developmental abnormalities: Endocrine systemTXAPA9 119,195,1993
oral/rat 500 mg/kg (12-21D pregnant)Reproductive: Effects on newborn: PhysicalTXAPA9 167,87,2000
oral/rat 2000 mg/kg (12D pre-7D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)REPTED 16,131,2002
oral/rat 300 mg/kg (12-17D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)REPTED 16,131,2002
oral/rat 400 mg/kg (12-19D pregnant)Reproductive: Effects on newborn: PhysicalREPTED 16,131,2002
oral/rat 500 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
REPTED 16,131,2002
oral/rat 500 mg/kg (12-21D pregnant)Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects

Reproductive: Effects on newborn: Germ cell effects (in offspring)
TOSCF2 65,62,2002
oral/rat 500 mg/kg (14-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 72(Suppl 1),272,2003
oral/rat 500 mg/kg (12-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 72(Suppl 1),275,2003
oral/rat 450 mg/kg (12-21D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TOSCF2 74,114,2003
oral/rat 450 mg/kg (12-21D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOSCF2 65,62,2002
oral/rat 400 mg/kg (12-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 44,352,2005
oral/rat 500 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,215,2001
oral/rat 75 mg/kg (13-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 90,251,2006
oral/rat 300 mg/kg (13-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 -,15,2009
oral/rat 300 mg/kg (13-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Endocrine system
TOLED5 186,73,2009
unreported route/rat 375 mg/kg (14-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 60,225,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 48 mg/m3/4H85GMAT -,48,1982
intraperitoneal/rat lethal dose (50 percent kill): 577 mg/kgRREVAH 77,126,1981
oral/chicken lethal dose (50 percent kill): 3765 mg/kgVETNAL 58(7),63,1982
oral/Dog lethal dose (50 percent kill): 500 mg/kgGUCHAZ 6,317,1973
oral/mouse lethal dose (50 percent kill): 1500 mg/kgYKYUA6 36,387,1985
oral/rabbit lethal dose (50 percent kill): 2250 mg/kg85JFAN A248,1984
oral/rat lethal dose (50 percent kill): 1146 mg/kgFAATDF 7,299,1986
skin/rabbit lethal dose (50 percent kill): >5 gm/kgPEMNDP 9,520,1991
skin/rat lethal dose (50 percent kill): >2500 mg/kgFAATDF 7,299,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/chicken lowest published toxic dose: 7500 mg/kg/30D- intermittentBehavioral: Muscle weakness

Cardiac: EKG changes not diagnostic of above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VETNAL 58(7),63,1982
oral/chicken lowest published toxic dose: 1 gm/kg/10D- intermittentBehavioral: Food intake (animal)

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RREVAH 77,135,1981
oral/Dog lowest published toxic dose: 11400 mg/kg/2Y- continuousLiver: Other changes

Blood: Other hemolysis with or without anemia

Blood: Changes in erythrocyte (RBC) count
FCTXAV 6,171,1968
oral/Dog lowest published toxic dose: 1050 mg/kg/7D- intermittentBlood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RREVAH 77,130,1981
oral/domestic animal lowest published toxic dose: 600 mg/kg/6D- intermittentBehavioral: Food intake (animal)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RREVAH 77,135,1981
oral/domestic animal lowest published toxic dose: 400 mg/kg/4D- intermittentBehavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RREVAH 77,135,1981
oral/domestic animal lowest published toxic dose: 1750 mg/kg/7D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VETNAL 58(7),63,1982
oral/rabbit lowest published toxic dose: 10 gm/kg/10D- intermittentCardiac: EKG changes not diagnostic of above

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VETNAL 58(7),63,1982
oral/rat lowest published toxic dose: 10 gm/kg/60D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
RPZHAW 21,145,1970
oral/rat lowest published toxic dose: 1070 mg/kg/31W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GISAAA 40(7),46,1975
oral/rat lowest published toxic dose: 1500 mg/kg/2W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JEPOEC 13,11,1994
oral/rat lowest published toxic dose: 2800 mg/kg/14D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight
TXAPA9 119,195,1993
oral/rat lowest published toxic dose: 2800 mg/kg/14D- continuousRelated to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
TXAPA9 119,195,1993
oral/rat lowest published toxic dose: 497 mg/kg/14D- continuousEndocrine: Change in LH

Endocrine: Estrogenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 119,195,1993
oral/rat lowest published toxic dose: 22750 mg/kg/2Y- continuousBlood: Other hemolysis with or without anemia

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTXAV 6,171,1968
oral/rat lowest published toxic dose: 500 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOSCF2 65,62,2002
oral/rat lowest published toxic dose: 1820 mg/kg/104W- continuousReproductive: Tumorigenic effects: Testicular tumorsHBPTO* 1,814,2001
oral/rat lowest published toxic dose: 375 mg/kg/15D- intermittentLiver: Changes in liver weightTOSCF2 69,92,2002
oral/rat lowest published toxic dose: 1500 mg/kg/15D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 69,92,2002
oral/rat lowest published toxic dose: 2250 mg/kg/15D- intermittentLiver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 69,92,2002
oral/rat lowest published toxic dose: 450 mg/kg/9D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOSCF2 74,114,2003
oral/rat lowest published toxic dose: 500 mg/kg/10D- intermittentRelated to Chronic Data: Changes in prostate weightTXCYAC 199,145,2004
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentEndocrine: Changes in adrenal weight

Related to Chronic Data: Changes in prostate weight
TXCYAC 199,145,2004
oral/rat lowest published toxic dose: 1369.2 mg/kg/12W- intermittentEndocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 213,13,2005
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXCYAC 239,77,2007
oral/rat lowest published toxic dose: 3000 mg/kg/60D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 180S,S167,2008
oral/rat lowest published toxic dose: 9000 mg/kg/180D- intermittentBlood: Hemorrhage

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 180S,S167,2008
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 262,114,2009
unreported route/rat lowest published toxic dose: 2800 mg/kg/14D- continuousEndocrine: Change in LH

Endocrine: Estrogenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
HBPTO* 1,734,2001
unreported route/rat lowest published toxic dose: 2800 mg/kg/14D- continuousReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsHBPTO* 1,734,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWMUREAV 627,106,2007
TOXICOLOGY REVIEWMUTAEX 20,245,2005
TOXICOLOGY REVIEWREPTED 22,291,2006
TOXICOLOGY REVIEWFEREAC 71,54953,2006
TOXICOLOGY REVIEWFEREAC 72,37646,2007
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFEREAC 73,51722,2008
TOXICOLOGY REVIEWFEREAC 75,864,2010
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWMUREAV 723,108,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,125,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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