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Urea, 3 - (3,4 - dichlorophenyl) - 1 - methoxy - 1 - methyl -

RTECS #: YS9100000

CAS #: 330-55-2


UPDATE: May 2009 MW: 249.11 MF: C9H10Cl2N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - (3,4 - Dichlorophenyl) 3 - methoxy - 3 - methyluree (French)
  2. 1 - Methoxy - 1 - methyl - 3 - (3,4 - dichlorophenyl) urea
  3. 3 - (3,4 - Dichloor - fenyl) - 1 - methoxy - 1 - methylureum (Dutch)
  4. 3 - (3,4 - Dichloro - fenil) - 1 - metossi - 1 - metil - urea (Italian)
  5. 3 - (3,4 - Dichlorophenyl) - 1 - methoxymethylurea
  6. 3 - (3,4 - Dichlorophenyl) - 1 - methoxy - 1 - methylurea
  7. 3 - (3,4 - Dichlor - phenyl) - 1 - methoxy - 1 - methyl - harnstoff (German)
  8. 3 - (4,5 - Dichlorphenyl) - 1 - methoxy - 1 - methylharnstoff (German)
  9. Afalon
  10. Afalon inuron
  11. Aphalon
  12. Cephalon
  13. Du Pont 326
  14. Dupont herbicide 326
  15. Garnitan
  16. HOE 2810
  17. Herbicide 326
  1. Laroks (Polish)
  2. Linex 4L
  3. Linorox
  4. Linurex
  5. Linuron
  6. Linuron (herbicide)
  7. Lorex
  8. Lorox
  9. Lorox linuron weed killer
  10. Methoxydiuron
  11. N' - (3,4 - Dichlorophenyl) - N - methoxy - N - methylurea
  12. N - (3,4 - Dichlorophenyl) - N' - methyl - N' - methoxyurea
  13. N - (3,4 - Dwuchlorofenylo) N' - metoksy - N' - metylomocznik (Polish)
  14. Sarclex
  15. Scarclex
  16. Sinuron


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage oral
rat
4,500 mg/kg/2 week- intermittent MUREAV 390,207,1997
DNA inhibition oral
mouse
500 mg/kg MUREAV 58,353,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 21.6876 mg/kg (62 day male) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 119,195,1993
oral
rat
lowest published toxic dose: 132.06 mg/kg (62 day male) Reproductive: Specific developmental abnormalities: Endocrine system TXAPA9 119,195,1993
oral
rat
lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Effects on newborn: Physical TXAPA9 167,87,2000
oral
rat
lowest published toxic dose: 2,000 mg/kg (12 day prior to copulation-7 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) REPTED 16,131,2002
oral
rat
lowest published toxic dose: 300 mg/kg (12-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 16,131,2002
oral
rat
lowest published toxic dose: 400 mg/kg (12-19 day pregnant) Reproductive: Effects on newborn: Physical REPTED 16,131,2002
oral
rat
lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
REPTED 16,131,2002
oral
rat
lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects

Reproductive: Effects on newborn: Germ cell effects (in offspring)
TOSCF2 65,62,2002
oral
rat
lowest published toxic dose: 500 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),272,2003
oral
rat
lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 72(Suppl 1),275,2003
oral
rat
lowest published toxic dose: 450 mg/kg (12-21 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TOSCF2 74,114,2003
oral
rat
lowest published toxic dose: 450 mg/kg (12-21 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOSCF2 65,62,2002
oral
rat
lowest published toxic dose: 400 mg/kg (12-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 44,352,2005
oral
rat
lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,215,2001
oral
rat
lowest published toxic dose: 75 mg/kg (13-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 90,251,2006
unreported route
rat
lowest published toxic dose: 375 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 60,225,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 48 mg/m3/4 hour N/R 85GMAT -,48,1982
intraperitoneal
rat
lethal dose (50 percent kill): 577 mg/kg N/R RREVAH 77,126,1981
oral
chicken
lethal dose (50 percent kill): 3,765 mg/kg N/R VETNAL 58(7),63,1982
oral
dog
lethal dose (50 percent kill): 500 mg/kg N/R GUCHAZ 6,317,1973
oral
mouse
lethal dose (50 percent kill): 1,500 mg/kg N/R YKYUA6 36,387,1985
oral
rat
lethal dose (50 percent kill): 1,146 mg/kg N/R FAATDF 7,299,1986
oral
rabbit
lethal dose (50 percent kill): 2,250 mg/kg N/R 85JFAN A248,1984
skin
rat
lethal dose (50 percent kill): >2,500 mg/kg N/R FAATDF 7,299,1986
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,520,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
chicken
lowest published toxic dose: 7,500 mg/kg/30 day- intermittent Behavioral: Muscle weakness

Cardiac: EKG changes not diagnostic of above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VETNAL 58(7),63,1982
oral
chicken
lowest published toxic dose: 1 gm/kg/10 day- intermittent Behavioral: Food intake (animal)

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RREVAH 77,135,1981
oral
dog
lowest published toxic dose: 11,400 mg/kg/2 year- continuous Liver: Other changes

Blood: Other hemolysis with or without anemia

Blood: Changes in erythrocyte (RBC) count
FCTXAV 6,171,1968
oral
dog
lowest published toxic dose: 1,050 mg/kg/7 day- intermittent Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RREVAH 77,130,1981
oral
domestic animal
lowest published toxic dose: 1,750 mg/kg/7 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VETNAL 58(7),63,1982
oral
domestic animal
lowest published toxic dose: 600 mg/kg/6 day- intermittent Behavioral: Food intake (animal)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RREVAH 77,135,1981
oral
domestic animal
lowest published toxic dose: 400 mg/kg/4 day- intermittent Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RREVAH 77,135,1981
oral
rat
lowest published toxic dose: 10 gm/kg/60 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
RPZHAW 21,145,1970
oral
rat
lowest published toxic dose: 1,070 mg/kg/31 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GISAAA 40(7),46,1975
oral
rat
lowest published toxic dose: 1,500 mg/kg/2 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JEPOEC 13,11,1994
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight
TXAPA9 119,195,1993
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- continuous Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
TXAPA9 119,195,1993
oral
rat
lowest published toxic dose: 497 mg/kg/14 day- continuous Endocrine: Change in LH

Endocrine: Estrogenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 119,195,1993
oral
rat
lowest published toxic dose: 22,750 mg/kg/2 year- continuous Blood: Other hemolysis with or without anemia

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTXAV 6,171,1968
oral
rat
lowest published toxic dose: 500 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 65,62,2002
oral
rat
lowest published toxic dose: 1,820 mg/kg/104 week- continuous Reproductive: Tumorigenic effects: Testicular tumors HBPTO* 1,814,2001
oral
rat
lowest published toxic dose: 375 mg/kg/15 day- intermittent Liver: Changes in liver weight TOSCF2 69,92,2002
oral
rat
lowest published toxic dose: 1,500 mg/kg/15 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 69,92,2002
oral
rat
lowest published toxic dose: 2,250 mg/kg/15 day- intermittent Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 69,92,2002
oral
rat
lowest published toxic dose: 450 mg/kg/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 74,114,2003
oral
rat
lowest published toxic dose: 500 mg/kg/10 day- intermittent Related to Chronic Data: Changes in prostate weight TXCYAC 199,145,2004
oral
rat
lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Endocrine: Changes in adrenal weight

Related to Chronic Data: Changes in prostate weight
TXCYAC 199,145,2004
oral
rat
lowest published toxic dose: 1,369.2 mg/kg/12 week- intermittent Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 213,13,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXCYAC 239,77,2007
oral
rabbit
lowest published toxic dose: 10 gm/kg/10 day- intermittent Cardiac: EKG changes not diagnostic of above

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VETNAL 58(7),63,1982
unreported route
rat
lowest published toxic dose: 2,800 mg/kg/14 day- continuous Endocrine: Change in LH

Endocrine: Estrogenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
HBPTO* 1,734,2001
unreported route
rat
lowest published toxic dose: 2,800 mg/kg/14 day- continuous Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands HBPTO* 1,734,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
MUREAV 627,106,2007
TOXICOLOGY REVIEW
MUTAEX 20,245,2005
TOXICOLOGY REVIEW
REPTED 22,291,2006
TOXICOLOGY REVIEW
FEREAC 71,54953,2006
TOXICOLOGY REVIEW
FEREAC 72,37646,2007
TOXICOLOGY REVIEW
FEREAC 72,37646,2007
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,125,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for selective weed control in field corn, grain sorghum, soybeans, carrots, etc.
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used for selective weed control in field corn, grain sorghum, soybeans, carrots, etc.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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