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Registry of Toxic Effects of Chemical Substances (RTECS)

Urea, 3-(3-chloro-p-tolyl)-1,1-dimethyl-

RTECS #

YS7230000

CAS #

15545-48-9

Updated

July 2011

Molecular Weight

212.70

Molecular Formula

C10H13ClN2O

Synonyms

3-(3-Chlor-4-methylphenyl)-1,1-dimethylharnstoff (German)
3-(3-Chloro-4-methylphenyl)-1,1-dimethyl-urea
C 2242
Chlorotoluron
Chlortoluron
Clortokem
Dicuran
Highuron
N-(3-Chloro-4-methylphenyl)-N',N'-dimethylurea
Tolurex

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisliver/hamster0.48 mg/L/20HMUREAV 721,89,2011
Cytogenetic Analysisovary/hamster96 mg/L/20HMUREAV 721,89,2011
DNA inhibitionoral/mouse200 mg/kgMUREAV 58,353,1978
mutation in microorganisms/Salmonella typhimurium1 µg/plate (-enzymatic activation step)MUREAV 58,353,1978
sister chromatid exchangeliver/hamster4.8 mg/LMUREAV 721,89,2011

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2 gm/kg (4D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
KHZDAN 22,362,1979
oral/rat 10 mg/kg (50D male)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)GISAAA 53(11),78,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1300 mg/m385DPAN -,-,1971/1976
oral/rat lethal dose (50 percent kill): 5800 mg/kgKHZDAN 22,362,1979
skin/rat lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,161,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 21 gm/kg/90D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
PSDTAP 12,272,1971

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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