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Urea, 3 - (3 - chloro - p - tolyl) - 1,1 - dimethyl -

RTECS #: YS7230000

CAS #: 15545-48-9


UPDATE: January 1997 MW: 212.70 MF: C10H13ClN2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 3 - (3 - Chlor - 4 - methylphenyl) - 1,1 - dimethylharnstoff (German)
  2. 3 - (3 - Chloro - 4 - methylphenyl) - 1,1 - dimethyl - urea
  3. C 2242
  4. Chlorotoluron
  5. Chlortoluron
  1. Clortokem
  2. Dicuran
  3. Highuron
  4. N - (3 - Chloro - 4 - methylphenyl) - N',N' - dimethylurea
  5. Tolurex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition oral
mouse
200 mg/kg MUREAV 58,353,1978
mutation in microorganisms Salmonella typhimurium 1 g/plate (-enzymatic activation step) MUREAV 58,353,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 2 gm/kg (4 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
KHZDAN 22,362,1979
oral
rat
lowest published toxic dose: 10 mg/kg (50 day male) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) GISAAA 53(11),78,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 1,300 mg/m3 N/R 85DPAN -,-,1971/1976
oral
rat
lethal dose (50 percent kill): 5,800 mg/kg N/R KHZDAN 22,362,1979
skin
rat
lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,161,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 21 gm/kg/90 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
PSDTAP 12,272,1971


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5.

Used as a residual soil-acting herbicide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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