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Registry of Toxic Effects of Chemical Substances (RTECS)

Urea, 3-(p-chlorophenyl)-1-methoxy-1-methyl-

RTECS #

YS6425000

CAS #

1746-81-2

Updated

April 2002

Molecular Weight

214.67

Molecular Formula

C9H11ClN2O2

Synonyms

3-(4-Chlorophenyl)-1-methoxy-1-methylurea
3-(4-Chlorphenyl)-1-methoxy-1-methylharnstoff (German)
Aresin
Arezin
Arezine
HOE 2747
Monolinuron
N-(4-Chlorophenyl)-N'-methoxy-N-methylurea
Urea, N'-(4-chlorophenyl)-N-methoxy-N-methyl-

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 8 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
ARTODN 38,261,1977
oral/mouse 8 gm/kg (6-15D pregnant)Reproductive: Other developmental abnormalitiesARTODN 38,261,1977
oral/mouse 4 gm/kg (10-13D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARTODN 38,261,1977
oral/mouse 1 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)ARTODN 38,261,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/chicken lethal dose (50 percent kill): 138 mg/kgRREVAH 77,126,1981
intraperitoneal/rat lethal dose (50 percent kill): 459 mg/kgRREVAH 77,126,1981
oral/cat lethal dose (50 percent kill): 63 mg/kgGastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RREVAH 77,123,1981
oral/chicken lethal dose (50 percent kill): 242 mg/kgRREVAH 77,126,1981
oral/Dog lethal dose (50 percent kill): 500 mg/kg28ZEAL 5,158,1976
oral/rat lethal dose (50 percent kill): 1800 mg/kgWRPCA2 9,119,1970
subcutaneous/mouse lethal dose (50 percent kill): 2645 mg/kgRREVAH 77,127,1981
subcutaneous/rat lethal dose (50 percent kill): 1093 mg/kgRREVAH 77,127,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 113 mg/kg/90D- continuousBlood: Normocytic anemiaRREVAH 77,131,1981
oral/rat lowest published toxic dose: 900 mg/kg/90D- continuousBlood: Normocytic anemiaRREVAH 77,131,1981

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDTTIAF 80,485,1973

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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