UPDATE: February 2009

MW: 270.03

MF: O2U

NOTE:

• TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.
  

TABLE OF CONTENTS:

1. ACUTE TOXICITY DATA:
   
2. OTHER MULTIPLE DOSE DATA:
   
3. REVIEWS:
   
4. STANDARDS AND REGULATIONS:
   
5. REFERENCES:
   

SYNONYMS:
N/R	N/R

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 375 mg/m3/2 hour	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTEHF8 69,1629,2006

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation dog	lowest published toxic concentration: 5.8 mg/m3/2 year- intermittent	Lung, Thorax, or Respiration: Other changes	VCVN1* -,281,1988
inhalation monkey	lowest published toxic concentration: 5.8 mg/m3/2 year- intermittent	Lung, Thorax, or Respiration: Fibrosis (interstitial)	VCVN1* -,281,1988

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 0.2 mg(U)/m3;short term exposure limit 0.6 mg(U)/m3	DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	Confirmed human carcinogen	DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW		ENTOX* -,406,2005
TOXICOLOGY REVIEW		HBTME* ,881,2007

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - BELGIUM	time-weighted average 0.2 mg(U)/m3, short term exposure limit 0.6 mg(U)/m3, MAR2002
Occupational Exposure Limit - KOREA	time-weighted average 0.2 mg(U)/m3, short term exposure limit 0.6 mg(U)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND	time-weighted average 0.2 mg(U)/m3, carcinogen, JAN2002
Occupational Exposure Limit - SWITZERLAND	MAK- week 0.2 mg(U)/m3, DEC2006

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
N/R	N/R	N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
N/R

REFERENCES:
CODEN	REFERENCE
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HBTME*
JTEHF8	Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
VCVN1*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us