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Registry of Toxic Effects of Chemical Substances (RTECS)

s-Trioxane, 2,4,6-trimethyl-

RTECS #

YK0525000

CAS #

123-63-7

Updated

December 2010

Molecular Weight

132.18

Molecular Formula

C6H12O3

Synonyms

2,4,6-Trimethyl-1,3,5-trioxaan (Dutch)
2,4,6-Trimethyl-1,3,5-trioxane
2,4,6-Trimethyl-s-trioxane
2,4,6-Trimetil-1,3,5-triossano (Italian)
Acetaldehyde, trimer
Elaldehyde
Paraacetaldehyde
Paracetaldehyde
Paral
Paraldehyd (German)
Paraldeide (Italian)
PCHO
RCRA waste number U182
s-Trimethyltrioxymethylene
Triacetaldehyde (French)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg severeUCDS** 3/24/1970
skin /rabbit 500 mg open irritation test mildUCDS** 3/24/1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HUCDS** 3/24/1970
intramuscular/man lowest published toxic dose: 568 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate increased without fall in BP

Biochemical: Metabolism (intermediary): Other
BJPYAJ 149,650,1986
intraperitoneal/mouse lethal dose (50 percent kill): 1257 mg/kgJPETAB 119,19,1957
intraperitoneal/rat lowest published lethal dose: 2100 mg/kgTXAPA9 1,156,1959
oral/cat lowest published lethal dose: 3300 mg/kgHBAMAK 4,1289,1935
oral/mouse lethal dose (50 percent kill): 2750 mg/kgJPETAB 119,19,1957
oral/rabbit lethal dose (50 percent kill): 3304 mg/kgPSEBAA 29,730,1932
oral/rat lethal dose (50 percent kill): 1530 mg/kgUCDS** 3/24/1970
rectal/man lowest published lethal dose: 333 mg/kgGastrointestinal: Necrotic changesSAMJAF 29,1021,1955
skin/rabbit lethal dose (50 percent kill): 14100 µL/kgUCDS** 3/24/1970
subcutaneous/rat lowest published lethal dose: 1650 mg/kgAEPPAE 182,348,1936
unreported route/man lowest published lethal dose: 1462 mg/kg85DCAI 2,73,1970

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCLCHAU 19,361,1973
TOXICOLOGY REVIEWFNSCA6 2,67,1973
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1332; Number of Industries 1; Total Number of Facilities 48; Number of Occupations 5; Total Number of Employees Exposed 2152; Total Number of Female Employees Exposed 1499

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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