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Registry of Toxic Effects of Chemical Substances (RTECS)

Triethylenetetramine

RTECS #

YE6650000

CAS #

112-24-3; 39421-77-7

Updated

July 2013

Molecular Weight

146.28

Molecular Formula

C6H18N4

Synonyms

1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-
1,4,7,10-Tetraazadecane
3,6-Diazaoctane-1,8-diamine
Araldite hardener HY 951
Araldite HY 951
DEH 24
Ethylenediamine, N,N'-bis(2-aminoethyl)-
HY 951
N,N-Bis(2-aminoethyl)-1,2-diaminoethane
N,N'-Bis(2-aminoethyl)ethylenediamine
Tecza
TETA
Trien
Trientine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 49 mg severeUCDS** 12/12/1966
eye /rabbit 20 mg/24H moderate85JCAE -,443,1986
skin /rabbit 490 mg open irritation test severeUCDS** 12/12/1966
skin /rabbit 5 mg/24H severe85JCAE -,443,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium500 nmol/plate (+enzymatic activation step)MUREAV 88,165,1981
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)ENMUDM 8(Suppl 7),1,1986
sister chromatid exchangeovary/hamster1 mg/LMUREAV 320,31,1994
Unscheduled DNA Synthesisliver/rat10 µg/LMUREAV 320,31,1994

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 9130 mg/kg (1-22D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities
LANCAO 1,1127,1982
oral/rat 17430 mg/kg (1-21D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
PSEBAA 173,598,1983
oral/rat 8715 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
PSEBAA 173,598,1983
skin/guinea pig 3667 mg/kg (10-56D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathAITEAT 22,123,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 468 mg/kgARTODN 61,321,1988
intravenous/mouse lethal dose (50 percent kill): 350 mg/kgEJMCA5 19,425,1984
oral/mouse lethal dose (50 percent kill): 38.5 mg/kgCBPCEE 128,119,2001
oral/rabbit lethal dose (50 percent kill): 5500 mg/kgKHZDAN 22,179,1979
oral/rat lethal dose (50 percent kill): 2500 mg/kg37ASAA 7,580,1979
skin/rabbit lethal dose (50 percent kill): 805 mg/kgJIHTAB 31,60,1949

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJJOMDZ 15,808,1973
TOXICOLOGY REVIEWCTOXAO 12,601,1978
TOXICOLOGY REVIEWMUREAV 488,151,2001
TOXICOLOGY REVIEWFCTOD7 49,1877,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (6 mg/m3), sen, NOV2011
Occupational Exposure Limit-POLANDtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (6 mg/m3);short term exposure limit 2 ppm (12 mg/m3), Sen, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82037; Number of Industries 96; Total Number of Facilities 7057; Number of Occupations 88; Total Number of Employees Exposed 165511; Total Number of Female Employees Exposed 20726
National Occupational Hazard Survey 1974Hazard Code 82037; Number of Industries 37; Total Number of Facilities 1982; Number of Occupations 44; Total Number of Employees Exposed 14389

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Triethylenetetramine, 2540
OSHA ANALYTICAL METHOD #ID-60
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