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Triethylene glycol

RTECS #: YE4550000

CAS #: 112-27-6


UPDATE: August 2008 MW: 150.20 MF: C6H14O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Bis (2 - hydroxyethoxy) ethane
  2. 2,2' - (1,2 - Ethanediylbis (oxy) ) bisethanol
  3. 2,2' - Ethylenedioxybis (ethanol)
  4. 2,2' - Ethylenedioxydiethanol
  5. 2,2' - Ethylenedioxyethanol
  6. 3,6 - Dioxaoctane - 1,8 - diol
  7. Di - beta - hydroxyethoxyethane
  8. Ethanol, 2,2' - (ethylenedioxy) di -
  1. Ethylene glycol - bis - (2 - hydroxyethyl ether)
  2. Ethylene glycol dihydroxydiethyl ether
  3. Glycol bis (hydroxyethyl) ether
  4. TEG
  5. Triethylenglykol (Czech)
  6. Trigen
  7. Triglycol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg mild AJOPAA 29,1363,1946
skin
rabbit
500 mg/24 hour mild FCTXAV 17,913,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
heritable translocation test skin
Drosophila melanogaster
1.32 mmol/L TOXID9 78,265,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 90,160 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 323 gm/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 18,602,1992
oral
mouse
lowest published toxic dose: 57,820 mg/kg (multigeneration) Reproductive: Effects on newborn: Physical FAATDF 18,602,1992
oral
mouse
lowest published toxic dose: 90,160 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 6.8 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Other postnatal measures or effects
NTIS** #PB88204300
oral
mouse
lowest published toxic dose: 115.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB88204300
oral
mouse
lowest published toxic dose: 56,300 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JAPTO* 25,418,2005
oral
rat
lowest published toxic dose: 103 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EPASR* 8EHQ-1190-1064
oral
rat
lowest published toxic dose: 300 mg/kg (1 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) VCVGK* -,146,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic dose: 4,545 mg/m3/30 minute Lung, Thorax, or Respiration: Respiratory depression JJATDK 26,387,2006
inhalation
rat
lowest published toxic dose: 5,020 mg/m3/4 hour Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Eye: Conjunctiva irritation

Eye: Other eye effects
JJATDK 26,387,2006
inhalation
rat
lethal concentration (50 percent kill): >4,400 mg/m3/4 hour N/R JAPTO* 27,291,2007
intramuscular
rat
lowest published lethal dose: 8,400 mg/kg Nutritional and Gross Metabolic: Body temperature decrease JAPMA8 29,5,1940
intraperitoneal
mouse
lethal dose (50 percent kill): 8,141 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal
mouse
lethal dose (50 percent kill): 8,141 mg/kg N/R JAPTO* 27,291,2007
intravenous
dog
lethal dose (50 percent kill): >4,500 mg/kg N/R JAPTO* 27,291,2007
intravenous
guinea pig
lethal dose (50 percent kill): 10,600 mg/kg N/R ARZNAD 18,1536,1968
intravenous
mouse
lethal dose (50 percent kill): 6,500 mg/kg N/R JAPTO* 27,291,2007
intravenous
rat
lethal dose (50 percent kill): 11,700 mg/kg N/R JAPTO* 27,291,2007
intravenous
rabbit
lethal dose (50 percent kill): 1,900 mg/kg N/R JAPTO* 27,291,2007
oral
guinea pig
lethal dose (50 percent kill): 7,900 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral
guinea pig
lethal dose (50 percent kill): 7,900 mg/kg N/R JAPTO* 27,291,2007
oral
human
lowest published lethal dose: 5 gm/kg N/R FCTXAV 17,913,1979
oral
mammal (species unspecified)
lethal dose (50 percent kill): 8,150 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse
lowest published lethal dose: 18,500 mg/kg N/R PCOC** -,1186,1966
oral
mouse
lethal dose (50 percent kill): 20,000 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral
mouse
lethal dose (50 percent kill): >18,500 mg/kg N/R JAPTO* 27,291,2007
oral
rat
lethal dose (50 percent kill): 17 gm/kg N/R JIHTAB 28,40,1946
oral
rat
lethal dose (50 percent kill): 15,000 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral
rabbit
lethal dose (50 percent kill): 8,400 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral
rabbit
lethal dose (50 percent kill): 8,400 mg/kg N/R JAPTO* 27,291,2007
subcutaneous
mouse
lethal dose (50 percent kill): 8,750 mg/kg N/R JPETAB 65,89,1939
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R 34ZIAG -,731,1969
skin
rabbit
lowest published lethal dose: 16 mL/kg/24 hour N/R JAPTO* 27,291,2007
unreported route
human
lowest published lethal dose: 5,000 mg/kg N/R VCVGK* -,146,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 4,824 mg/m3/12 hour/2 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JJATDK 26,387,2006
inhalation
rat
lowest published toxic concentration: 2,011 mg/m3/12 hour/2 day- intermittent Eye: Other eye effects JJATDK 26,387,2006
inhalation
rat
lowest published toxic concentration: 2,011 mg/m3/30 hour/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JJATDK 26,387,2006
inhalation
rat
lowest published toxic concentration: 494 mg/m3/54 hour/11 day- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake
JJATDK 26,387,2006
inhalation
rat
lowest published toxic concentration: 2,011 mg/m3/48 hour/10 day- intermittent Behavioral: Fluid intake JJATDK 26,387,2006
inhalation
rat
lowest published toxic concentration: 2,011 mg/m3/54 hour/11 day- intermittent Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JJATDK 26,387,2006
inhalation
rat
lowest published toxic concentration: 494 mg/m3/54 hour/11 day- intermittent Nutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JJATDK 26,387,2006
inhalation
rat
lowest published toxic concentration: 2,011 mg/m3/54 hour/11 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
JJATDK 26,387,2006
inhalation
rat
lowest published toxic concentration: 494 mg/m3/9 day- intermittent Behavioral: Fluid intake

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JAPTO* 27,291,2007
inhalation
rat
lowest published toxic concentration: 2,011 mg/m3/9 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JAPTO* 27,291,2007
inhalation
rat
lowest published toxic concentration: 4,824 mg/m3/2 day- intermittent Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPTO* 27,291,2007
oral
mouse
lowest published toxic dose: 90,160 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 33,780 mg/kg/3 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Fluid intake

Lung, Thorax, or Respiration: Dyspnea
JAPTO* 25,418,2005
oral
mouse
lowest published toxic dose: 112,600 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight JAPTO* 25,418,2005
oral
rat
lowest published toxic dose: 455 mg/kg/13 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 52(11),86,1987
oral
rat
lowest published toxic dose: 650 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 52(12),77,1987
oral
rat
lowest published toxic dose: 910 mg/kg/26 week- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1994
oral
rat
lowest published toxic dose: 910 mg/kg/26 week- intermittent Blood: Changes in bone marrow not included in above

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,147,1994
oral
rat
lowest published toxic dose: 17.5 gm/kg/7 day- continuous Behavioral: Food intake (animal) VHTODE 43,269,2001
oral
rat
lowest published toxic dose: 42 gm/kg/14 day- continuous Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased
VHTODE 43,269,2001
oral
rat
lowest published toxic dose: 35 gm/kg/14 day- continuous Kidney, Ureter, and Bladder: Urine volume increased VHTODE 43,269,2001
oral
rat
lowest published toxic dose: 140 gm/kg/8 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,269,2001
oral
rat
lowest published toxic dose: 45 gm/kg/90 day- continuous Brain and Coverings: Changes in brain weight VHTODE 43,269,2001
oral
rat
lowest published toxic dose: 33,780 mg/kg/3 day- intermittent Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 25,418,2005
oral
rat
lowest published toxic dose: 112,600 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight JAPTO* 25,418,2005
oral
rat
lowest published toxic dose: 56,300 mg/kg/10 day- intermittent Behavioral: Fluid intake JAPTO* 25,418,2005
oral
rat
lowest published toxic dose: 67,320 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 27,291,2007
oral
rat
lowest published toxic dose: 136,980 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in erythrocyte (RBC) count
JAPTO* 27,291,2007
oral
rat
lowest published toxic dose: 215,544 mg/kg/56 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 27,291,2007
oral
rat
lowest published toxic dose: 436,410 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 27,291,2007
oral
rat
lowest published toxic dose: 152,910 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 27,291,2007
oral
rat
lowest published toxic dose: 392,400 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 27,291,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FAATDF 13,747,1989


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,283,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 mg/m3,KZG- week 2000 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80354;
Number of Industries 120;
Total Number of Facilities 18,128;
Number of Occupations 97;
Total Number of Employees Exposed 146,703
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80354;
Number of Industries 119;
Total Number of Facilities 23,174;
Number of Occupations 100;
Total Number of Employees Exposed 233,613;
Total Number of Female Employees Exposed 53,367


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as antifreeze, chemical intermediate, humectant, plasticizer, solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Glycols, 5523


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as antifreeze, chemical intermediate, humectant, plasticizer, solvent

NIOSH PROFILE (GLYCOLS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector
   Human Data
   Primary Irritant

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