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Registry of Toxic Effects of Chemical Substances (RTECS)

Triethylene glycol

RTECS #

YE4550000

CAS #

112-27-6

Updated

July 2013

Molecular Weight

150.20

Molecular Formula

C6H14O4

Synonyms

1,2-Bis(2-hydroxyethoxy)ethane
2,2'-(1,2-Ethanediylbis(oxy))bisethanol
2,2'-Ethylenedioxybis(ethanol)
2,2'-Ethylenedioxydiethanol
2,2'-Ethylenedioxyethanol
3,6-Dioxaoctane-1,8-diol
Di-beta-hydroxyethoxyethane
Ethanol, 2,2'-(ethylenedioxy)di-
Ethylene glycol dihydroxydiethyl ether
Ethylene glycol-bis-(2-hydroxyethyl ether)
Glycol bis(hydroxyethyl) ether
TEG
Triethylenglykol (Czech)
Trigen
Triglycol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg mildAJOPAA 29,1363,1946
skin /rabbit 500 mg/24H mildFCTXAV 17,913,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
heritable translocation testskin/Drosophila melanogaster1.32 mmol/LTOXID9 78,265,2004

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 103 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EPASR* 8EHQ-1190-1064
oral/mouse 90160 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)EVHPAZ 57,141,1984
oral/mouse 323 gm/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FAATDF 18,602,1992
oral/mouse 57820 mg/kg (multigeneration)Reproductive: Effects on newborn: PhysicalFAATDF 18,602,1992
oral/mouse 90160 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effectsEVHPAZ 57,141,1984
oral/rat 300 mg/kg (1D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)VCVGK* -,146,1994
oral/mouse 6.8 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Other postnatal measures or effects
NTIS** #PB88204300
oral/mouse 115.5 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB88204300
oral/mouse 56300 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JAPTO* 25,418,2005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic dose: 4545 mg/m3/30MLung, Thorax, or Respiration: Respiratory depressionJJATDK 26,387,2006
inhalation/rat lowest published toxic dose: 5020 mg/m3/4HPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Eye: Conjunctiva irritation

Eye: Other eye effects
JJATDK 26,387,2006
inhalation/rat lethal concentration (50 percent kill): >4400 mg/m3/4HJAPTO* 27,291,2007
intramuscular/rat lowest published lethal dose: 8400 mg/kgNutritional and Gross Metabolic: Body temperature decreaseJAPMA8 29,5,1940
intraperitoneal/mouse lethal dose (50 percent kill): 8141 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal/mouse lethal dose (50 percent kill): 8141 mg/kgJAPTO* 27,291,2007
intravenous/Dog lethal dose (50 percent kill): >4500 mg/kgJAPTO* 27,291,2007
intravenous/guinea pig lethal dose (50 percent kill): 10600 mg/kgARZNAD 18,1536,1968
intravenous/mouse lethal dose (50 percent kill): 6500 mg/kgJAPTO* 27,291,2007
intravenous/rabbit lethal dose (50 percent kill): 1900 mg/kgJAPTO* 27,291,2007
intravenous/rat lethal dose (50 percent kill): 11700 mg/kgJAPTO* 27,291,2007
oral/guinea pig lethal dose (50 percent kill): 7900 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral/guinea pig lethal dose (50 percent kill): 7900 mg/kgJAPTO* 27,291,2007
oral/human lowest published lethal dose: 5 gm/kgFCTXAV 17,913,1979
oral/mammal (species unspecified) lethal dose (50 percent kill): 8150 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 20000 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral/mouse lowest published lethal dose: 18500 mg/kgPCOC** -,1186,1966
oral/mouse lethal dose (50 percent kill): >18500 mg/kgJAPTO* 27,291,2007
oral/rabbit lethal dose (50 percent kill): 8400 mg/kgJAPTO* 27,291,2007
oral/rabbit lethal dose (50 percent kill): 8400 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
oral/rat lethal dose (50 percent kill): 17 gm/kgJIHTAB 28,40,1946
oral/rat lethal dose (50 percent kill): 15000 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1984
skin/rabbit lethal dose (50 percent kill): >20 mL/kg34ZIAG -,731,1969
skin/rabbit lowest published lethal dose: 16 mL/kg/24HJAPTO* 27,291,2007
subcutaneous/mouse lethal dose (50 percent kill): 8750 mg/kgJPETAB 65,89,1939
unreported route/human lowest published lethal dose: 5000 mg/kgVCVGK* -,146,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 4824 mg/m3/12H/2D- intermittentBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/12H/2D- intermittentEye: Other eye effectsJJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/30H/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 494 mg/m3/54H/11D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/48H/10D- intermittentBehavioral: Fluid intakeJJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/54H/11D- intermittentKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 494 mg/m3/54H/11D- intermittentNutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 2011 mg/m3/54H/11D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
JJATDK 26,387,2006
inhalation/rat lowest published toxic concentration: 494 mg/m3/9D- intermittentBehavioral: Fluid intake

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JAPTO* 27,291,2007
inhalation/rat lowest published toxic concentration: 2011 mg/m3/9D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JAPTO* 27,291,2007
inhalation/rat lowest published toxic concentration: 4824 mg/m3/2D- intermittentBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPTO* 27,291,2007
oral/mouse lowest published toxic dose: 33780 mg/kg/3D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Fluid intake

Lung, Thorax, or Respiration: Dyspnea
JAPTO* 25,418,2005
oral/mouse lowest published toxic dose: 112600 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightJAPTO* 25,418,2005
oral/mouse lowest published toxic dose: 90160 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/rat lowest published toxic dose: 910 mg/kg/26W- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,146,1994
oral/rat lowest published toxic dose: 910 mg/kg/26W- intermittentBlood: Changes in bone marrow not included in above

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,147,1994
oral/rat lowest published toxic dose: 17.5 gm/kg/7D- continuousBehavioral: Food intake (animal)VHTODE 43,269,2001
oral/rat lowest published toxic dose: 42 gm/kg/14D- continuousBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased
VHTODE 43,269,2001
oral/rat lowest published toxic dose: 35 gm/kg/14D- continuousKidney, Ureter, and Bladder: Urine volume increasedVHTODE 43,269,2001
oral/rat lowest published toxic dose: 140 gm/kg/8W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainVHTODE 43,269,2001
oral/rat lowest published toxic dose: 45 gm/kg/90D- continuousBrain and Coverings: Changes in brain weightVHTODE 43,269,2001
oral/rat lowest published toxic dose: 67320 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 136980 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in erythrocyte (RBC) count
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 215544 mg/kg/56D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 27,291,2007
oral/rat lowest published toxic dose: 436410 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 152910 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 392400 mg/kg/90D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 27,291,2007
oral/rat lowest published toxic dose: 33780 mg/kg/3D- intermittentBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 25,418,2005
oral/rat lowest published toxic dose: 112600 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightJAPTO* 25,418,2005
oral/rat lowest published toxic dose: 56300 mg/kg/10D- intermittentBehavioral: Fluid intakeJAPTO* 25,418,2005
oral/rat lowest published toxic dose: 455 mg/kg/13W- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 52(11),86,1987
oral/rat lowest published toxic dose: 650 mg/kg/26W- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 52(12),77,1987

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFAATDF 13,747,1989

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,283,1998
Occupational Exposure Limit-GERMANYMAK 1000 mg/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 mg/m3, KZG-week 2000 mg/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80354; Number of Industries 119; Total Number of Facilities 23174; Number of Occupations 100; Total Number of Employees Exposed 233613; Total Number of Female Employees Exposed 53367
National Occupational Hazard Survey 1974Hazard Code 80354; Number of Industries 120; Total Number of Facilities 18128; Number of Occupations 97; Total Number of Employees Exposed 146703

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Glycols, 5523
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