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Registry of Toxic Effects of Chemical Substances (RTECS)

Tributylamine

RTECS #

YA0350000

CAS #

102-82-9

Updated

February 2006

Molecular Weight

185.40

Molecular Formula

C12H27N

Synonyms

1-Butanamine, N,N-dibutyl-
Tributilamina (Romanian)
Tri-n-butylamine
Tris-n-butylamine

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 75 ppm/4HTXAPA9 28,313,1974
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 107 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GTPZAB 28(11),50,1984
oral/guinea pig lethal dose (50 percent kill): 350 mg/kgGISAAA 42(12),36,1977
oral/mammal (species unspecified) lethal dose (50 percent kill): 888 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GTPZAB 28(11),50,1984
oral/mouse lethal dose (50 percent kill): 114 mg/kgGISAAA 42(12),36,1977
oral/rabbit lethal dose (50 percent kill): 615 mg/kgGISAAA 42(12),36,1977
oral/rat lethal dose (50 percent kill): 114 mg/kgTLSMA6 115,57,1977
skin/rabbit lethal dose (50 percent kill): 250 µL/kgTXAPA9 28,313,1974
subcutaneous/rat lowest published lethal dose: 380 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
JPETAB 20,435,1923

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mammal (species unspecified) lowest published toxic dose: 107 mg/kg/3D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase
GTPZAB 28(11),50,1984
oral/rabbit lowest published toxic dose: 1119 mg/kg/26W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
GISAAA 42(12),36,1977

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCHREAY 9,389,1931

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83937; Number of Industries 36; Total Number of Facilities 2898; Number of Occupations 31; Total Number of Employees Exposed 51214; Total Number of Female Employees Exposed 15366
National Occupational Hazard Survey 1974Hazard Code 83937; Number of Industries 48; Total Number of Facilities 2039; Number of Occupations 33; Total Number of Employees Exposed 27671

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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