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Registry of Toxic Effects of Chemical Substances (RTECS)

1H-1,2,4-Triazole, 1-((4-bromo-2-(2,4-dichlorophenyl)tetrahydro-2-furanyl)methyl)-

RTECS #

XZ4130000

CAS #

116255-48-2

Updated

October 2011

Molecular Weight

377.09

Molecular Formula

C13H12BrCl2N3O

Synonyms

1-((2RS,4RS,2RS,4SR)-4-Bromo-2-(2,4-dichlorophenyl)tetrahydrofurfuryl)-1H-1,2,4-triazole
1-((4-Bromo-2-(2,4-dichlorophenyl)tetrahydro-2-furanyl)methyl)-1H-1,2,4-triazole
Bromoconazole
Bromuconazole
LC 860263
LS 860263

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lethal concentration (50 percent kill): >5 gm/m3PEMNDP 9,1140,1991
oral/duck lethal dose (50 percent kill): >2150 mg/kgPEMNDP 9,1140,1991
oral/mouse lethal dose (50 percent kill): 1151 mg/kgPEMNDP 9,1140,1991
oral/quail lethal dose (50 percent kill): >2150 mg/kgPEMNDP 9,1140,1991
oral/rat lethal dose (50 percent kill): 365 mg/kgPEMNDP 9,1140,1991
skin/rat lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,1140,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 15 gm/kg/13W- intermittentEye: Conjunctiva irritation

Liver: Other changes

Blood: Changes in leukocyte (WBC) count
NTIS** OTS0537618
oral/Dog lowest published toxic dose: 14 gm/kg/4W- intermittentBehavioral: Tremor

Behavioral: Ataxia

Blood: Changes in leukocyte (WBC) count
NTIS** OTS0537619
oral/mouse lowest published toxic dose: 23520 mg/kg/7W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0540967
oral/rat lowest published toxic dose: 36400 mg/kg/1Y- continuousLiver: Fatty liver degeneration

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536968
oral/rat lowest published toxic dose: 4550 mg/kg/13W- continuousLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0537617
oral/rat lowest published toxic dose: 11200 mg/kg/4W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired

Blood: Changes in platelet count
NTIS** OTS0537620

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 31,392,2011

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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